The effect of soy consumption on inflammatory biomarkers: A systematic review and meta-analysis of clinical trials

Mahsa Rezazadegan; Fatemeh Mirjalili; Cain C T Clark; Mohammad Hossein Rouhani

doi:10.1017/S0007114520003268

The effect of soy consumption on inflammatory biomarkers: A systematic review and meta-analysis of clinical trials

Mahsa Rezazadegan, Fatemeh Mirjalili, Cain C T Clark, Mohammad Hossein Rouhani

Faculty Research Centre for Intelligent Healthcare

Research output: Contribution to journal › Review article › peer-review

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Abstract

Inflammation is a major cause of chronic diseases. Several studies have investigated the effects of soy intake on inflammatory biomarkers; however, the results are equivocal. The aim of this study was to conduct a systematic review and meta-analysis of clinical trials that evaluated the effect of soy consumption on inflammatory biomarkers. Medline, Scopus, ISI Web of Science, and Google Scholar were systematically searched, up to and including May 2020, for clinical trials that evaluated the effects of soy and soy products on tumor necrosis factor α (TNF-α), Interleukin-6 (IL-6), Interleukin-2 (IL-2), Interleukin1-β (IL1-β), and Interferon gamma (IFN-γ) in adults. A random-effects method was used to calculate overall effects, and subgroup analyses were performed to discern probable sources of inter-study heterogeneity. A total of 28 clinical trials were included. Although soy consumption reduced TNF-α (Hedges' g= -0.28; 95%CI: -0.49, -0.07), it had no significant effect on IL-6 (Hedges' g= 0.07, 95% CI: -0.14, 0.28), IL-2 (MD= -1.38 pg/ml; 95%CI: -3.07, 0.31), IL1-β (MD= -0.02 pg/ml; 95%CI: -0.08, 0.03), and IFN-γ (MD= 1685.82 pg/ml; 95%CI: -1604.86, 4976.50). Subgroup analysis illustrated a reduction in TNF-α in in parallel designed studies, at dosages ≥100 mg of isoflavones, and in unhealthy subjects. The present study showed that high doses of isoflavones in unhealthy subjects may yield beneficial effects on TNF-α.

Original language	English
Pages (from-to)	(In-press)
Number of pages	26
Journal	British Journal of Nutrition
Volume	(In-press)
Early online date	20 Aug 2020
DOIs	https://doi.org/10.1017/S0007114520003268
Publication status	E-pub ahead of print - 20 Aug 2020

Bibliographical note

Copyright © and Moral Rights are retained by the author(s) and/ or other copyright owners. A copy can be downloaded for personal non-commercial research or study, without prior permission or charge. This item cannot be reproduced or quoted extensively from without first obtaining permission in writing from the copyright holder(s). The content must not be changed in any way or sold commercially in any format or medium without the formal permission of the copyright holders.

Keywords

Keywords:
inflammation
interleukin
meta-analysis
soy
tumor necrosis factor α

ASJC Scopus subject areas

Medicine (miscellaneous)
Nutrition and Dietetics

Access to Document

10.1017/S0007114520003268

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title = "The effect of soy consumption on inflammatory biomarkers: A systematic review and meta-analysis of clinical trials",

abstract = "Inflammation is a major cause of chronic diseases. Several studies have investigated the effects of soy intake on inflammatory biomarkers; however, the results are equivocal. The aim of this study was to conduct a systematic review and meta-analysis of clinical trials that evaluated the effect of soy consumption on inflammatory biomarkers. Medline, Scopus, ISI Web of Science, and Google Scholar were systematically searched, up to and including May 2020, for clinical trials that evaluated the effects of soy and soy products on tumor necrosis factor α (TNF-α), Interleukin-6 (IL-6), Interleukin-2 (IL-2), Interleukin1-β (IL1-β), and Interferon gamma (IFN-γ) in adults. A random-effects method was used to calculate overall effects, and subgroup analyses were performed to discern probable sources of inter-study heterogeneity. A total of 28 clinical trials were included. Although soy consumption reduced TNF-α (Hedges' g= -0.28; 95%CI: -0.49, -0.07), it had no significant effect on IL-6 (Hedges' g= 0.07, 95% CI: -0.14, 0.28), IL-2 (MD= -1.38 pg/ml; 95%CI: -3.07, 0.31), IL1-β (MD= -0.02 pg/ml; 95%CI: -0.08, 0.03), and IFN-γ (MD= 1685.82 pg/ml; 95%CI: -1604.86, 4976.50). Subgroup analysis illustrated a reduction in TNF-α in in parallel designed studies, at dosages ≥100 mg of isoflavones, and in unhealthy subjects. The present study showed that high doses of isoflavones in unhealthy subjects may yield beneficial effects on TNF-α.",

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author = "Mahsa Rezazadegan and Fatemeh Mirjalili and Clark, {Cain C T} and Rouhani, {Mohammad Hossein}",

note = "Copyright {\textcopyright} and Moral Rights are retained by the author(s) and/ or other copyright owners. A copy can be downloaded for personal non-commercial research or study, without prior permission or charge. This item cannot be reproduced or quoted extensively from without first obtaining permission in writing from the copyright holder(s). The content must not be changed in any way or sold commercially in any format or medium without the formal permission of the copyright holders. ",

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T2 - A systematic review and meta-analysis of clinical trials

AU - Rezazadegan, Mahsa

AU - Mirjalili, Fatemeh

AU - Clark, Cain C T

AU - Rouhani, Mohammad Hossein

N1 - Copyright © and Moral Rights are retained by the author(s) and/ or other copyright owners. A copy can be downloaded for personal non-commercial research or study, without prior permission or charge. This item cannot be reproduced or quoted extensively from without first obtaining permission in writing from the copyright holder(s). The content must not be changed in any way or sold commercially in any format or medium without the formal permission of the copyright holders.

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N2 - Inflammation is a major cause of chronic diseases. Several studies have investigated the effects of soy intake on inflammatory biomarkers; however, the results are equivocal. The aim of this study was to conduct a systematic review and meta-analysis of clinical trials that evaluated the effect of soy consumption on inflammatory biomarkers. Medline, Scopus, ISI Web of Science, and Google Scholar were systematically searched, up to and including May 2020, for clinical trials that evaluated the effects of soy and soy products on tumor necrosis factor α (TNF-α), Interleukin-6 (IL-6), Interleukin-2 (IL-2), Interleukin1-β (IL1-β), and Interferon gamma (IFN-γ) in adults. A random-effects method was used to calculate overall effects, and subgroup analyses were performed to discern probable sources of inter-study heterogeneity. A total of 28 clinical trials were included. Although soy consumption reduced TNF-α (Hedges' g= -0.28; 95%CI: -0.49, -0.07), it had no significant effect on IL-6 (Hedges' g= 0.07, 95% CI: -0.14, 0.28), IL-2 (MD= -1.38 pg/ml; 95%CI: -3.07, 0.31), IL1-β (MD= -0.02 pg/ml; 95%CI: -0.08, 0.03), and IFN-γ (MD= 1685.82 pg/ml; 95%CI: -1604.86, 4976.50). Subgroup analysis illustrated a reduction in TNF-α in in parallel designed studies, at dosages ≥100 mg of isoflavones, and in unhealthy subjects. The present study showed that high doses of isoflavones in unhealthy subjects may yield beneficial effects on TNF-α.

AB - Inflammation is a major cause of chronic diseases. Several studies have investigated the effects of soy intake on inflammatory biomarkers; however, the results are equivocal. The aim of this study was to conduct a systematic review and meta-analysis of clinical trials that evaluated the effect of soy consumption on inflammatory biomarkers. Medline, Scopus, ISI Web of Science, and Google Scholar were systematically searched, up to and including May 2020, for clinical trials that evaluated the effects of soy and soy products on tumor necrosis factor α (TNF-α), Interleukin-6 (IL-6), Interleukin-2 (IL-2), Interleukin1-β (IL1-β), and Interferon gamma (IFN-γ) in adults. A random-effects method was used to calculate overall effects, and subgroup analyses were performed to discern probable sources of inter-study heterogeneity. A total of 28 clinical trials were included. Although soy consumption reduced TNF-α (Hedges' g= -0.28; 95%CI: -0.49, -0.07), it had no significant effect on IL-6 (Hedges' g= 0.07, 95% CI: -0.14, 0.28), IL-2 (MD= -1.38 pg/ml; 95%CI: -3.07, 0.31), IL1-β (MD= -0.02 pg/ml; 95%CI: -0.08, 0.03), and IFN-γ (MD= 1685.82 pg/ml; 95%CI: -1604.86, 4976.50). Subgroup analysis illustrated a reduction in TNF-α in in parallel designed studies, at dosages ≥100 mg of isoflavones, and in unhealthy subjects. The present study showed that high doses of isoflavones in unhealthy subjects may yield beneficial effects on TNF-α.

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KW - inflammation

KW - interleukin

KW - meta-analysis

KW - soy

KW - tumor necrosis factor α

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