The effect of sour cherry consumption on blood pressure, IL-6, CRP, and TNF-α levels: A systematic review and meta-analysis of randomized controlled trials sour cherry consumption and blood pressure

Baizhi Han, Akshaya Srikanth Bhagavathul, Muhammed Rashid, Manik Chhabra, Cain Clark, Hebatullah Abdulazeem, Mohamed Abd-ElGawad, Hamed Kord Varkaneh, Jamal Rahmani, Yong Zhang

Research output: Contribution to journalReview article

Abstract

Abstract
Objectives: Cherries are rich in polyphenols and anthocyanins and are believed to possess strong anti inflammatory activity and cardio-protective effects. This study aim was to summarize the overall effect of
sour cherry consumption on blood pressure and biomarkers associated with the inflammation.
Methods: MEDLINE/PubMed, Cochrane, and Scopus were searched to find relevant papers up to April 2019. There were no time and language restrictions. This systematic review and meta-analysis was
performed in accordance with the Preferred Items for Reporting of Systematic Reviews and Meta-Analyses
(PRISMA) guidelines.
Results: Eleven studies with 275 participants were included in this meta-analysis. Mean dose of the sour cherry was 170 mL/day, whilst mean duration of interventions was six weeks. Combined the results using
random-effects model showed significant reductions in diastolic blood pressure levels following sour cherry
consumption (WMD: -2.32mmHg, 95% CI: -4.45, -0.19, I2=39%), but there were no significant changes in
systolic blood pressure (WMD: -2.64mmHg, 95% CI: -5.84, 0.56, I2=33%), IL-6 levels (WMD: 0.12
pg/mL, 95% CI: -0.13, 0.36, I2=49%), hs-CRP (WMD: -0.13 mg/mL, 95% CI: -0.47, 0.22, I2=49%) or
TNF-α (WMD: -0.07 pg/mL, 95% CI: -0.18, 0.05, I2=00%).
Conclusion: Sour cherry supplementation results a decrease in diastolic blood pressure, but elicits no significant effect on systolic blood pressure, IL-6 levels, CRP levels and TNF-α.
Original languageEnglish
Number of pages21
JournalJournal of King Saud University - Computer and Information Sciences
Volume(In-Press)
Early online date9 Jan 2020
DOIs
Publication statusE-pub ahead of print - 9 Jan 2020

Fingerprint

Blood pressure
Anthocyanins
Biomarkers

Keywords

  • Blood pressure
  • Inflammation
  • Sour cherry

ASJC Scopus subject areas

  • General

Cite this

The effect of sour cherry consumption on blood pressure, IL-6, CRP, and TNF-α levels : A systematic review and meta-analysis of randomized controlled trials sour cherry consumption and blood pressure. / Han, Baizhi ; Bhagavathul, Akshaya Srikanth ; Rashid, Muhammed ; Chhabra, Manik ; Clark, Cain; Abdulazeem, Hebatullah; Abd-ElGawad, Mohamed ; Varkaneh, Hamed Kord ; Rahmani, Jamal; Zhang, Yong.

In: Journal of King Saud University - Computer and Information Sciences, Vol. (In-Press), 09.01.2020.

Research output: Contribution to journalReview article

Han, Baizhi ; Bhagavathul, Akshaya Srikanth ; Rashid, Muhammed ; Chhabra, Manik ; Clark, Cain ; Abdulazeem, Hebatullah ; Abd-ElGawad, Mohamed ; Varkaneh, Hamed Kord ; Rahmani, Jamal ; Zhang, Yong. / The effect of sour cherry consumption on blood pressure, IL-6, CRP, and TNF-α levels : A systematic review and meta-analysis of randomized controlled trials sour cherry consumption and blood pressure. In: Journal of King Saud University - Computer and Information Sciences. 2020 ; Vol. (In-Press).
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abstract = "AbstractObjectives: Cherries are rich in polyphenols and anthocyanins and are believed to possess strong anti inflammatory activity and cardio-protective effects. This study aim was to summarize the overall effect of sour cherry consumption on blood pressure and biomarkers associated with the inflammation. Methods: MEDLINE/PubMed, Cochrane, and Scopus were searched to find relevant papers up to April 2019. There were no time and language restrictions. This systematic review and meta-analysis was performed in accordance with the Preferred Items for Reporting of Systematic Reviews and Meta-Analyses (PRISMA) guidelines.Results: Eleven studies with 275 participants were included in this meta-analysis. Mean dose of the sour cherry was 170 mL/day, whilst mean duration of interventions was six weeks. Combined the results using random-effects model showed significant reductions in diastolic blood pressure levels following sour cherry consumption (WMD: -2.32mmHg, 95{\%} CI: -4.45, -0.19, I2=39{\%}), but there were no significant changes in systolic blood pressure (WMD: -2.64mmHg, 95{\%} CI: -5.84, 0.56, I2=33{\%}), IL-6 levels (WMD: 0.12 pg/mL, 95{\%} CI: -0.13, 0.36, I2=49{\%}), hs-CRP (WMD: -0.13 mg/mL, 95{\%} CI: -0.47, 0.22, I2=49{\%}) or TNF-α (WMD: -0.07 pg/mL, 95{\%} CI: -0.18, 0.05, I2=00{\%}). Conclusion: Sour cherry supplementation results a decrease in diastolic blood pressure, but elicits no significant effect on systolic blood pressure, IL-6 levels, CRP levels and TNF-α.",
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author = "Baizhi Han and Bhagavathul, {Akshaya Srikanth} and Muhammed Rashid and Manik Chhabra and Cain Clark and Hebatullah Abdulazeem and Mohamed Abd-ElGawad and Varkaneh, {Hamed Kord} and Jamal Rahmani and Yong Zhang",
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T1 - The effect of sour cherry consumption on blood pressure, IL-6, CRP, and TNF-α levels

T2 - A systematic review and meta-analysis of randomized controlled trials sour cherry consumption and blood pressure

AU - Han, Baizhi

AU - Bhagavathul, Akshaya Srikanth

AU - Rashid, Muhammed

AU - Chhabra, Manik

AU - Clark, Cain

AU - Abdulazeem, Hebatullah

AU - Abd-ElGawad, Mohamed

AU - Varkaneh, Hamed Kord

AU - Rahmani, Jamal

AU - Zhang, Yong

PY - 2020/1/9

Y1 - 2020/1/9

N2 - AbstractObjectives: Cherries are rich in polyphenols and anthocyanins and are believed to possess strong anti inflammatory activity and cardio-protective effects. This study aim was to summarize the overall effect of sour cherry consumption on blood pressure and biomarkers associated with the inflammation. Methods: MEDLINE/PubMed, Cochrane, and Scopus were searched to find relevant papers up to April 2019. There were no time and language restrictions. This systematic review and meta-analysis was performed in accordance with the Preferred Items for Reporting of Systematic Reviews and Meta-Analyses (PRISMA) guidelines.Results: Eleven studies with 275 participants were included in this meta-analysis. Mean dose of the sour cherry was 170 mL/day, whilst mean duration of interventions was six weeks. Combined the results using random-effects model showed significant reductions in diastolic blood pressure levels following sour cherry consumption (WMD: -2.32mmHg, 95% CI: -4.45, -0.19, I2=39%), but there were no significant changes in systolic blood pressure (WMD: -2.64mmHg, 95% CI: -5.84, 0.56, I2=33%), IL-6 levels (WMD: 0.12 pg/mL, 95% CI: -0.13, 0.36, I2=49%), hs-CRP (WMD: -0.13 mg/mL, 95% CI: -0.47, 0.22, I2=49%) or TNF-α (WMD: -0.07 pg/mL, 95% CI: -0.18, 0.05, I2=00%). Conclusion: Sour cherry supplementation results a decrease in diastolic blood pressure, but elicits no significant effect on systolic blood pressure, IL-6 levels, CRP levels and TNF-α.

AB - AbstractObjectives: Cherries are rich in polyphenols and anthocyanins and are believed to possess strong anti inflammatory activity and cardio-protective effects. This study aim was to summarize the overall effect of sour cherry consumption on blood pressure and biomarkers associated with the inflammation. Methods: MEDLINE/PubMed, Cochrane, and Scopus were searched to find relevant papers up to April 2019. There were no time and language restrictions. This systematic review and meta-analysis was performed in accordance with the Preferred Items for Reporting of Systematic Reviews and Meta-Analyses (PRISMA) guidelines.Results: Eleven studies with 275 participants were included in this meta-analysis. Mean dose of the sour cherry was 170 mL/day, whilst mean duration of interventions was six weeks. Combined the results using random-effects model showed significant reductions in diastolic blood pressure levels following sour cherry consumption (WMD: -2.32mmHg, 95% CI: -4.45, -0.19, I2=39%), but there were no significant changes in systolic blood pressure (WMD: -2.64mmHg, 95% CI: -5.84, 0.56, I2=33%), IL-6 levels (WMD: 0.12 pg/mL, 95% CI: -0.13, 0.36, I2=49%), hs-CRP (WMD: -0.13 mg/mL, 95% CI: -0.47, 0.22, I2=49%) or TNF-α (WMD: -0.07 pg/mL, 95% CI: -0.18, 0.05, I2=00%). Conclusion: Sour cherry supplementation results a decrease in diastolic blood pressure, but elicits no significant effect on systolic blood pressure, IL-6 levels, CRP levels and TNF-α.

KW - Blood pressure

KW - Inflammation

KW - Sour cherry

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U2 - 10.1016/j.jksus.2020.01.002

DO - 10.1016/j.jksus.2020.01.002

M3 - Review article

VL - (In-Press)

JO - Journal of King Saud University - Computer and Information Sciences

JF - Journal of King Saud University - Computer and Information Sciences

SN - 1319-1578

ER -