The effect of sour cherry consumption on blood pressure, IL-6, CRP, and TNF-α levels: A systematic review and meta-analysis of randomized controlled trials sour cherry consumption and blood pressure

Baizhi Han, Akshaya Srikanth Bhagavathul, Muhammed Rashid, Manik Chhabra, Cain Clark, Hebatullah Abdulazeem, Mohamed Abd-ElGawad, Hamed Kord Varkaneh, Jamal Rahmani, Yong Zhang

Research output: Contribution to journalReview article

1 Citation (Scopus)


Objectives: Cherries are rich in polyphenols and anthocyanins and are believed to possess strong anti inflammatory activity and cardio-protective effects. This study aim was to summarize the overall effect of
sour cherry consumption on blood pressure and biomarkers associated with the inflammation.
Methods: MEDLINE/PubMed, Cochrane, and Scopus were searched to find relevant papers up to April 2019. There were no time and language restrictions. This systematic review and meta-analysis was
performed in accordance with the Preferred Items for Reporting of Systematic Reviews and Meta-Analyses
(PRISMA) guidelines.
Results: Eleven studies with 275 participants were included in this meta-analysis. Mean dose of the sour cherry was 170 mL/day, whilst mean duration of interventions was six weeks. Combined the results using
random-effects model showed significant reductions in diastolic blood pressure levels following sour cherry
consumption (WMD: -2.32mmHg, 95% CI: -4.45, -0.19, I2=39%), but there were no significant changes in
systolic blood pressure (WMD: -2.64mmHg, 95% CI: -5.84, 0.56, I2=33%), IL-6 levels (WMD: 0.12
pg/mL, 95% CI: -0.13, 0.36, I2=49%), hs-CRP (WMD: -0.13 mg/mL, 95% CI: -0.47, 0.22, I2=49%) or
TNF-α (WMD: -0.07 pg/mL, 95% CI: -0.18, 0.05, I2=00%).
Conclusion: Sour cherry supplementation results a decrease in diastolic blood pressure, but elicits no significant effect on systolic blood pressure, IL-6 levels, CRP levels and TNF-α.
Original languageEnglish
Pages (from-to)1687-1693
Number of pages7
JournalJournal of King Saud University - Computer and Information Sciences
Issue number2
Early online date9 Jan 2020
Publication statusPublished - 1 Mar 2020



  • Blood pressure
  • Inflammation
  • Sour cherry

ASJC Scopus subject areas

  • General

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