The effect of Saffron supplementation on waist circumference, HA1C, and glucose metabolism: A systematic review and meta-analysis of randomized clinical trials

Jamal Rahmani; Elham  Bazmi; Cain Clark; Seyed Saeed Hashemi  Nazarid

doi:10.1016/j.ctim.2020.102298

The effect of Saffron supplementation on waist circumference, HA1C, and glucose metabolism: A systematic review and meta-analysis of randomized clinical trials

Jamal Rahmani, Elham Bazmi, Cain Clark, Seyed Saeed Hashemi Nazarid

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19 Citations (Scopus)

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Abstract

Objective: Carotenoids (including zeaxanthin and lycopene) and phytosterols reportedly confer beneficial effects on metabolic profile and function, which is of clinical importance. Thus, we sought to review the saffron effects on waist circumstance (WC), fasting plasma glucose (FPG), and HA1C concentrations reported in Randomized Control Trials (RCTs). Method: A comprehensive systematic electronic search was performed in PubMed/MEDLINE, Embase, Google Scholar, Cochrane, Web of sciences, and SCOPUS to identify RCTs up to February 2019 without any language restrictions. The pooled weighted mean difference (WMD) calculated with DerSimonian-Laird random. PRISMA guidelines adhered to for this meta-analysis. Result: Nine articles with 12 arms containing 595 participants were included in this study. Our study found WC was significantly reduced (WMD: −2.18 cm, 95 % CI: −4.05, −0.32) and FPG (WMD: −6.54 mg/dl, 95 % CI: −10.22, −2.85) following saffron intervention. Subgroup analysis highlighted that FPG levels (WMD: −10.24 mg/dl, 95 % CI: −15.76, −4.72) reduced significantly when intervention duration was longer than twelve weeks. There was no significant effect on HA1C levels (WMD: −0.13 mg/dl, 95 % CI: −0.31, 0.04) following saffron intervention. Conclusion: In conclusion, the present study indicates beneficial effects on WC and FPG, following saffron supplementation.

Original language	English
Article number	102298
Journal	Complementary Therapies in Medicine
Volume	49
Early online date	7 Jan 2020
DOIs	https://doi.org/10.1016/j.ctim.2020.102298
Publication status	Published - Mar 2020

Bibliographical note

NOTICE: this is the author’s version of a work that was accepted for publication in Complementary Therapies in Medicine. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Complementary Therapies in Medicine, 49, (2020)
DOI: 10.1016/j.ctim.2020.102298

© 2020, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/

Keywords

Crocin
Glucose
HA1C
Saffron
Waist circumstance

ASJC Scopus subject areas

Complementary and Manual Therapy
Complementary and alternative medicine
Advanced and Specialised Nursing

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10.1016/j.ctim.2020.102298

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The effect of Saffron supplementation on waist circumference, HA1C, and glucose metabolism: A systematic review and meta-analysis of randomized clinical trials. / Rahmani, Jamal; Bazmi, Elham ; Clark, Cain; Nazarid, Seyed Saeed Hashemi .

In: Complementary Therapies in Medicine, Vol. 49, 102298, 03.2020.

Research output: Contribution to journal › Article › peer-review

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title = "The effect of Saffron supplementation on waist circumference, HA1C, and glucose metabolism: A systematic review and meta-analysis of randomized clinical trials",

abstract = "Objective: Carotenoids (including zeaxanthin and lycopene) and phytosterols reportedly confer beneficial effects on metabolic profile and function, which is of clinical importance. Thus, we sought to review the saffron effects on waist circumstance (WC), fasting plasma glucose (FPG), and HA1C concentrations reported in Randomized Control Trials (RCTs). Method: A comprehensive systematic electronic search was performed in PubMed/MEDLINE, Embase, Google Scholar, Cochrane, Web of sciences, and SCOPUS to identify RCTs up to February 2019 without any language restrictions. The pooled weighted mean difference (WMD) calculated with DerSimonian-Laird random. PRISMA guidelines adhered to for this meta-analysis. Result: Nine articles with 12 arms containing 595 participants were included in this study. Our study found WC was significantly reduced (WMD: −2.18 cm, 95 % CI: −4.05, −0.32) and FPG (WMD: −6.54 mg/dl, 95 % CI: −10.22, −2.85) following saffron intervention. Subgroup analysis highlighted that FPG levels (WMD: −10.24 mg/dl, 95 % CI: −15.76, −4.72) reduced significantly when intervention duration was longer than twelve weeks. There was no significant effect on HA1C levels (WMD: −0.13 mg/dl, 95 % CI: −0.31, 0.04) following saffron intervention. Conclusion: In conclusion, the present study indicates beneficial effects on WC and FPG, following saffron supplementation.",

keywords = "Crocin, Glucose, HA1C, Saffron, Waist circumstance",

author = "Jamal Rahmani and Elham Bazmi and Cain Clark and Nazarid, {Seyed Saeed Hashemi}",

note = "NOTICE: this is the author{\textquoteright}s version of a work that was accepted for publication in Complementary Therapies in Medicine. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Complementary Therapies in Medicine, 49, (2020) DOI: 10.1016/j.ctim.2020.102298 {\textcopyright} 2020, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ ",

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AU - Rahmani, Jamal

AU - Bazmi, Elham

AU - Clark, Cain

AU - Nazarid, Seyed Saeed Hashemi

N1 - NOTICE: this is the author’s version of a work that was accepted for publication in Complementary Therapies in Medicine. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Complementary Therapies in Medicine, 49, (2020) DOI: 10.1016/j.ctim.2020.102298 © 2020, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/

PY - 2020/3

Y1 - 2020/3

N2 - Objective: Carotenoids (including zeaxanthin and lycopene) and phytosterols reportedly confer beneficial effects on metabolic profile and function, which is of clinical importance. Thus, we sought to review the saffron effects on waist circumstance (WC), fasting plasma glucose (FPG), and HA1C concentrations reported in Randomized Control Trials (RCTs). Method: A comprehensive systematic electronic search was performed in PubMed/MEDLINE, Embase, Google Scholar, Cochrane, Web of sciences, and SCOPUS to identify RCTs up to February 2019 without any language restrictions. The pooled weighted mean difference (WMD) calculated with DerSimonian-Laird random. PRISMA guidelines adhered to for this meta-analysis. Result: Nine articles with 12 arms containing 595 participants were included in this study. Our study found WC was significantly reduced (WMD: −2.18 cm, 95 % CI: −4.05, −0.32) and FPG (WMD: −6.54 mg/dl, 95 % CI: −10.22, −2.85) following saffron intervention. Subgroup analysis highlighted that FPG levels (WMD: −10.24 mg/dl, 95 % CI: −15.76, −4.72) reduced significantly when intervention duration was longer than twelve weeks. There was no significant effect on HA1C levels (WMD: −0.13 mg/dl, 95 % CI: −0.31, 0.04) following saffron intervention. Conclusion: In conclusion, the present study indicates beneficial effects on WC and FPG, following saffron supplementation.

AB - Objective: Carotenoids (including zeaxanthin and lycopene) and phytosterols reportedly confer beneficial effects on metabolic profile and function, which is of clinical importance. Thus, we sought to review the saffron effects on waist circumstance (WC), fasting plasma glucose (FPG), and HA1C concentrations reported in Randomized Control Trials (RCTs). Method: A comprehensive systematic electronic search was performed in PubMed/MEDLINE, Embase, Google Scholar, Cochrane, Web of sciences, and SCOPUS to identify RCTs up to February 2019 without any language restrictions. The pooled weighted mean difference (WMD) calculated with DerSimonian-Laird random. PRISMA guidelines adhered to for this meta-analysis. Result: Nine articles with 12 arms containing 595 participants were included in this study. Our study found WC was significantly reduced (WMD: −2.18 cm, 95 % CI: −4.05, −0.32) and FPG (WMD: −6.54 mg/dl, 95 % CI: −10.22, −2.85) following saffron intervention. Subgroup analysis highlighted that FPG levels (WMD: −10.24 mg/dl, 95 % CI: −15.76, −4.72) reduced significantly when intervention duration was longer than twelve weeks. There was no significant effect on HA1C levels (WMD: −0.13 mg/dl, 95 % CI: −0.31, 0.04) following saffron intervention. Conclusion: In conclusion, the present study indicates beneficial effects on WC and FPG, following saffron supplementation.

KW - Crocin

KW - Glucose

KW - HA1C

KW - Saffron

KW - Waist circumstance

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JO - Complementary Therapies in Medicine

JF - Complementary Therapies in Medicine

SN - 0965-2299

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ER -

The effect of Saffron supplementation on waist circumference, HA1C, and glucose metabolism: A systematic review and meta-analysis of randomized clinical trials

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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