The effect of saffron supplementation on blood pressure in adults: A systematic review and dose-response meta-analysis of randomized controlled trials

Leila Setayesh; Damoon Ashtary-Larky; Cain C.T. Clark; Mahnaz Rezaei Kelishadi; Pardis Khalili; Reza Bagheri; Omid Asbaghi; Katsuhiko Suzuki

doi:10.3390/nu13082736

The effect of saffron supplementation on blood pressure in adults: A systematic review and dose-response meta-analysis of randomized controlled trials

Leila Setayesh, Damoon Ashtary-Larky, Cain C.T. Clark, Mahnaz Rezaei Kelishadi, Pardis Khalili, Reza Bagheri, Omid Asbaghi, Katsuhiko Suzuki

Research Centre for Intelligent Healthcare

Research output: Contribution to journal › Review article › peer-review

4 Citations (Scopus)

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Abstract

Background: The favorable influences of saffron supplementation on metabolic diseases have previously been shown. We aimed to assess the effects of saffron supplementation on blood pressure in adults. Methods: A systematic search was performed in Scopus, Embase, and the Cochrane library databases to find randomized controlled trials (RCTs) related to the effect of saffron supple-mentation on blood pressure in adults up to March 2021. The primary search yielded 182 publications, of which eight RCTs were eligible. Results: Our results showed that saffron supplementation resulted in a significant decrease in systolic blood pressure (weighted mean difference (WMD): −0.65 mmHg; 95% CI: −1.12 to −0.18, p = 0.006) and diastolic blood pressure (DBP) (WMD: −1.23 mmHg; 95% CI: −1.64 to −0.81, p < 0.001). Moreover, saffron supplementation reduced DBP in a non-linear fashion, based on duration (r = −2.45, p-nonlinearity = 0.008). Conclusions: Saffron supplementation may significantly improve both systolic and diastolic blood pressure in adults. It should be noted that the hypotensive effects of saffron supplementation were small and may not reach clinical importance.

Original language	English
Article number	2736
Number of pages	15
Journal	Nutrients
Volume	13
Issue number	8
DOIs	https://doi.org/10.3390/nu13082736
Publication status	Published - 9 Aug 2021

Bibliographical note

This article is an open access article distributed under the terms and
conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

Keywords

Blood pressure
Meta-analysis
Saffron
Systematic review

ASJC Scopus subject areas

Food Science
Nutrition and Dietetics

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The effect of saffron supplementation on blood pressure in adults : A systematic review and dose-response meta-analysis of randomized controlled trials. / Setayesh, Leila; Ashtary-Larky, Damoon; Clark, Cain C.T.; Rezaei Kelishadi, Mahnaz; Khalili, Pardis; Bagheri, Reza; Asbaghi, Omid; Suzuki, Katsuhiko.

In: Nutrients, Vol. 13, No. 8, 2736, 09.08.2021.

Research output: Contribution to journal › Review article › peer-review

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abstract = "Background: The favorable influences of saffron supplementation on metabolic diseases have previously been shown. We aimed to assess the effects of saffron supplementation on blood pressure in adults. Methods: A systematic search was performed in Scopus, Embase, and the Cochrane library databases to find randomized controlled trials (RCTs) related to the effect of saffron supple-mentation on blood pressure in adults up to March 2021. The primary search yielded 182 publications, of which eight RCTs were eligible. Results: Our results showed that saffron supplementation resulted in a significant decrease in systolic blood pressure (weighted mean difference (WMD): −0.65 mmHg; 95% CI: −1.12 to −0.18, p = 0.006) and diastolic blood pressure (DBP) (WMD: −1.23 mmHg; 95% CI: −1.64 to −0.81, p < 0.001). Moreover, saffron supplementation reduced DBP in a non-linear fashion, based on duration (r = −2.45, p-nonlinearity = 0.008). Conclusions: Saffron supplementation may significantly improve both systolic and diastolic blood pressure in adults. It should be noted that the hypotensive effects of saffron supplementation were small and may not reach clinical importance.",

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The effect of saffron supplementation on blood pressure in adults: A systematic review and dose-response meta-analysis of randomized controlled trials

Abstract

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