Abstract
Plant derivatives such as carotenoids and phytosterols enrich foods have been shown to reduce plasma triglyceride (TG), low-density lipoprotein (LDL) cholesterol, and cholesterol concentrations. The aim of this systematic review and meta-analyses study was to investigate the effects of saffron on lipid profiles, reported in randomized controlled trials (RCTs). We performed a systematic electronic search in PubMed/MEDLINE, Cochrane, and SCOPUS to identify RCTs and screening of relevant articles references up to October 12, 2018. There were no language restrictions. We performed this systematic review and meta-analysis according to the Preferred Items for Reporting of Systematic Reviews and Meta-Analyses guidelines. We identified and analyzed 14 eligible studies in this meta-analysis. Our study found a significant reduction in cholesterol and TG following saffron intervention (weighted mean difference [WMD]: −6.36 mg/dl, 95% confidence interval, CI, [−10.58, −2.18] and WMD: −5.37 mg/dl, 95% CI [−10.25, −0.48], respectively). There was no significant effect on weight and LDL concentration. A meta-regression analysis showed that long-term saffron intervention can increase the high-density lipoprotein (HDL) levels. In conclusions, our study findings indicate some benefits of saffron on cholesterol, HDL, and TG compared with placebo. However, we recommend the conduct of adequately powered, high-quality RCTs with short- and long-term follow-up, evaluating relevant clinical outcomes to allow for making definitive recommendations.
| Original language | English |
|---|---|
| Pages (from-to) | (In-press) |
| Journal | Phytotherapy Research |
| Volume | (In-press) |
| Early online date | 2 Jul 2019 |
| DOIs | |
| Publication status | E-pub ahead of print - 2 Jul 2019 |
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Keywords
- Saffron
- Crocin
- Weight
- Triglyceride
- Cholesterol
- LDL
Cite this
The effect of Saffron on weight and lipid profile : A systematic review, meta-analysis and dose-response of randomized clinical trials. / Rahmani, Jamal; Manzari, Nicla; Thompson, Jacqueline ; Clark, Cain; Villaneuva, Gemma; Varkaneh, Hamed Kord ; Mirmiran, Parvin.
In: Phytotherapy Research, Vol. (In-press), 02.07.2019, p. (In-press).Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - The effect of Saffron on weight and lipid profile
T2 - A systematic review, meta-analysis and dose-response of randomized clinical trials
AU - Rahmani, Jamal
AU - Manzari, Nicla
AU - Thompson, Jacqueline
AU - Clark, Cain
AU - Villaneuva, Gemma
AU - Varkaneh, Hamed Kord
AU - Mirmiran, Parvin
PY - 2019/7/2
Y1 - 2019/7/2
N2 - Plant derivatives such as carotenoids and phytosterols enrich foods have been shown to reduce plasma triglyceride (TG), low-density lipoprotein (LDL) cholesterol, and cholesterol concentrations. The aim of this systematic review and meta-analyses study was to investigate the effects of saffron on lipid profiles, reported in randomized controlled trials (RCTs). We performed a systematic electronic search in PubMed/MEDLINE, Cochrane, and SCOPUS to identify RCTs and screening of relevant articles references up to October 12, 2018. There were no language restrictions. We performed this systematic review and meta-analysis according to the Preferred Items for Reporting of Systematic Reviews and Meta-Analyses guidelines. We identified and analyzed 14 eligible studies in this meta-analysis. Our study found a significant reduction in cholesterol and TG following saffron intervention (weighted mean difference [WMD]: −6.36 mg/dl, 95% confidence interval, CI, [−10.58, −2.18] and WMD: −5.37 mg/dl, 95% CI [−10.25, −0.48], respectively). There was no significant effect on weight and LDL concentration. A meta-regression analysis showed that long-term saffron intervention can increase the high-density lipoprotein (HDL) levels. In conclusions, our study findings indicate some benefits of saffron on cholesterol, HDL, and TG compared with placebo. However, we recommend the conduct of adequately powered, high-quality RCTs with short- and long-term follow-up, evaluating relevant clinical outcomes to allow for making definitive recommendations.
AB - Plant derivatives such as carotenoids and phytosterols enrich foods have been shown to reduce plasma triglyceride (TG), low-density lipoprotein (LDL) cholesterol, and cholesterol concentrations. The aim of this systematic review and meta-analyses study was to investigate the effects of saffron on lipid profiles, reported in randomized controlled trials (RCTs). We performed a systematic electronic search in PubMed/MEDLINE, Cochrane, and SCOPUS to identify RCTs and screening of relevant articles references up to October 12, 2018. There were no language restrictions. We performed this systematic review and meta-analysis according to the Preferred Items for Reporting of Systematic Reviews and Meta-Analyses guidelines. We identified and analyzed 14 eligible studies in this meta-analysis. Our study found a significant reduction in cholesterol and TG following saffron intervention (weighted mean difference [WMD]: −6.36 mg/dl, 95% confidence interval, CI, [−10.58, −2.18] and WMD: −5.37 mg/dl, 95% CI [−10.25, −0.48], respectively). There was no significant effect on weight and LDL concentration. A meta-regression analysis showed that long-term saffron intervention can increase the high-density lipoprotein (HDL) levels. In conclusions, our study findings indicate some benefits of saffron on cholesterol, HDL, and TG compared with placebo. However, we recommend the conduct of adequately powered, high-quality RCTs with short- and long-term follow-up, evaluating relevant clinical outcomes to allow for making definitive recommendations.
KW - Saffron
KW - Crocin
KW - Weight
KW - Triglyceride
KW - Cholesterol
KW - LDL
UR - http://www.scopus.com/inward/record.url?scp=85068522051&partnerID=8YFLogxK
U2 - 10.1002/ptr.6420
DO - 10.1002/ptr.6420
M3 - Review article
VL - (In-press)
SP - (In-press)
JO - Phytotherapy Research
JF - Phytotherapy Research
SN - 0951-418X
ER -