The effect of Nigella sativa (black seed) supplementation on body weight and body composition: A GRADE-assessed systematic review and dose-response meta-analysis of randomized controlled trials

Navid Naghsh; Amir Hossein Moridpour; Zeynab Kavyani; Vali Musazadeh; Jaber Jafarzadeh; Ehsan Safaei; Cain C.T. Clark; Amir Hossein Faghfouri

doi:10.1016/j.jff.2023.105565

The effect of Nigella sativa (black seed) supplementation on body weight and body composition: A GRADE-assessed systematic review and dose-response meta-analysis of randomized controlled trials

Navid Naghsh
, Amir Hossein Moridpour
, Zeynab Kavyani
, Vali Musazadeh
, Jaber Jafarzadeh
, Ehsan Safaei
, Cain C.T. Clark
, Amir Hossein Faghfouri

Shahid Sadoughi University of Medical Sciences
Tabriz University of Medical Sciences
Urmia University of Medical Sciences

Research output: Contribution to journal › Review article › peer-review

19 Citations (Scopus)

471 Downloads (Pure)

Abstract

Many studies have suggested that Nigella Sativa supplementation may exert a beneficial effect on anthropometric indices; however, the findings are inconclusive. Therefore, this study was conducted to obtain an updated finding in this regard. Systematic search was conducted in PubMed, Cochrane Library, Web of Science, Scopus, Embase databases, and Google Scholar, up to August 2022. N. sativa supplementation significantly reduced BW (WMD = −1.46 kg; 95 % CI: −2.53, −0.39) and BMI (WMD: −0.58 kg/m², 95 % CI: −0.86, −0.29) compared to placebo group. However, no significant reductions were found in WC (WMD: −2.54 cm, 95 % CI: −6.27, 1.19), HC (WMD: −1.92 cm; 95 % CI: −4.38 to 0.54), and WHR (WMD = −0.03; 95 % CI: −0.07, 0.01). The current meta-analysis revealed that N. sativa supplementation in adults led to a significant decrease in body weight and BMI, but not WC, HC, and WHR. Thus, according to our findings, N. sativa supplementation can be recommended as an adjunctive intervention in obesity management.

Original language	English
Article number	105565
Number of pages	13
Journal	Journal of Functional Foods
Volume	105
DOIs	https://doi.org/10.1016/j.jff.2023.105565
Publication status	Published - 17 May 2023

Bibliographical note

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/bync-nd/4.0/).

Funding

The Tabriz University of Medical Sciences Student Research Committee accepted and supported the research protocol (Registration code: 71125).

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Nigella sativa
Body composition
Obesity
Body mass index
Meta-analysis

ASJC Scopus subject areas

Food Science
Medicine (miscellaneous)
Nutrition and Dietetics

Access to Document

10.1016/j.jff.2023.105565Licence: CC BY-NC-ND

PublishedFinal published version, 2.45 MBLicence: CC BY-NC-ND

Cite this

Naghsh, N., Moridpour, A. H., Kavyani, Z., Musazadeh, V., Jafarzadeh, J., Safaei, E., Clark, C. C. T., & Faghfouri, A. H. (2023). The effect of Nigella sativa (black seed) supplementation on body weight and body composition: A GRADE-assessed systematic review and dose-response meta-analysis of randomized controlled trials. Journal of Functional Foods, 105, Article 105565. https://doi.org/10.1016/j.jff.2023.105565

The effect of Nigella sativa (black seed) supplementation on body weight and body composition: A GRADE-assessed systematic review and dose-response meta-analysis of randomized controlled trials. / Naghsh, Navid; Moridpour, Amir Hossein; Kavyani, Zeynab et al.
In: Journal of Functional Foods, Vol. 105, 105565, 17.05.2023.

Research output: Contribution to journal › Review article › peer-review

Naghsh, N, Moridpour, AH, Kavyani, Z, Musazadeh, V, Jafarzadeh, J, Safaei, E, Clark, CCT & Faghfouri, AH 2023, 'The effect of Nigella sativa (black seed) supplementation on body weight and body composition: A GRADE-assessed systematic review and dose-response meta-analysis of randomized controlled trials', Journal of Functional Foods, vol. 105, 105565. https://doi.org/10.1016/j.jff.2023.105565

@article{1a94d99540bf4c98aea914d0a626d4a2,

title = "The effect of Nigella sativa (black seed) supplementation on body weight and body composition: A GRADE-assessed systematic review and dose-response meta-analysis of randomized controlled trials",

abstract = "Many studies have suggested that Nigella Sativa supplementation may exert a beneficial effect on anthropometric indices; however, the findings are inconclusive. Therefore, this study was conducted to obtain an updated finding in this regard. Systematic search was conducted in PubMed, Cochrane Library, Web of Science, Scopus, Embase databases, and Google Scholar, up to August 2022. N. sativa supplementation significantly reduced BW (WMD = −1.46 kg; 95 \% CI: −2.53, −0.39) and BMI (WMD: −0.58 kg/m2, 95 \% CI: −0.86, −0.29) compared to placebo group. However, no significant reductions were found in WC (WMD: −2.54 cm, 95 \% CI: −6.27, 1.19), HC (WMD: −1.92 cm; 95 \% CI: −4.38 to 0.54), and WHR (WMD = −0.03; 95 \% CI: −0.07, 0.01). The current meta-analysis revealed that N. sativa supplementation in adults led to a significant decrease in body weight and BMI, but not WC, HC, and WHR. Thus, according to our findings, N. sativa supplementation can be recommended as an adjunctive intervention in obesity management.",

keywords = "Nigella sativa, Body composition, Obesity, Body mass index, Meta-analysis",

author = "Navid Naghsh and Moridpour, \{Amir Hossein\} and Zeynab Kavyani and Vali Musazadeh and Jaber Jafarzadeh and Ehsan Safaei and Clark, \{Cain C.T.\} and Faghfouri, \{Amir Hossein\}",

note = "This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/bync-nd/4.0/). ",

year = "2023",

month = may,

day = "17",

doi = "10.1016/j.jff.2023.105565",

language = "English",

volume = "105",

journal = "Journal of Functional Foods",

issn = "1756-4646",

publisher = "Elsevier",

}

TY - JOUR

T1 - The effect of Nigella sativa (black seed) supplementation on body weight and body composition

T2 - A GRADE-assessed systematic review and dose-response meta-analysis of randomized controlled trials

AU - Naghsh, Navid

AU - Moridpour, Amir Hossein

AU - Kavyani, Zeynab

AU - Musazadeh, Vali

AU - Jafarzadeh, Jaber

AU - Safaei, Ehsan

AU - Clark, Cain C.T.

AU - Faghfouri, Amir Hossein

N1 - This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/bync-nd/4.0/).

PY - 2023/5/17

Y1 - 2023/5/17

N2 - Many studies have suggested that Nigella Sativa supplementation may exert a beneficial effect on anthropometric indices; however, the findings are inconclusive. Therefore, this study was conducted to obtain an updated finding in this regard. Systematic search was conducted in PubMed, Cochrane Library, Web of Science, Scopus, Embase databases, and Google Scholar, up to August 2022. N. sativa supplementation significantly reduced BW (WMD = −1.46 kg; 95 % CI: −2.53, −0.39) and BMI (WMD: −0.58 kg/m2, 95 % CI: −0.86, −0.29) compared to placebo group. However, no significant reductions were found in WC (WMD: −2.54 cm, 95 % CI: −6.27, 1.19), HC (WMD: −1.92 cm; 95 % CI: −4.38 to 0.54), and WHR (WMD = −0.03; 95 % CI: −0.07, 0.01). The current meta-analysis revealed that N. sativa supplementation in adults led to a significant decrease in body weight and BMI, but not WC, HC, and WHR. Thus, according to our findings, N. sativa supplementation can be recommended as an adjunctive intervention in obesity management.

AB - Many studies have suggested that Nigella Sativa supplementation may exert a beneficial effect on anthropometric indices; however, the findings are inconclusive. Therefore, this study was conducted to obtain an updated finding in this regard. Systematic search was conducted in PubMed, Cochrane Library, Web of Science, Scopus, Embase databases, and Google Scholar, up to August 2022. N. sativa supplementation significantly reduced BW (WMD = −1.46 kg; 95 % CI: −2.53, −0.39) and BMI (WMD: −0.58 kg/m2, 95 % CI: −0.86, −0.29) compared to placebo group. However, no significant reductions were found in WC (WMD: −2.54 cm, 95 % CI: −6.27, 1.19), HC (WMD: −1.92 cm; 95 % CI: −4.38 to 0.54), and WHR (WMD = −0.03; 95 % CI: −0.07, 0.01). The current meta-analysis revealed that N. sativa supplementation in adults led to a significant decrease in body weight and BMI, but not WC, HC, and WHR. Thus, according to our findings, N. sativa supplementation can be recommended as an adjunctive intervention in obesity management.

KW - Nigella sativa

KW - Body composition

KW - Obesity

KW - Body mass index

KW - Meta-analysis

UR - https://www.scopus.com/pages/publications/85159350815

U2 - 10.1016/j.jff.2023.105565

DO - 10.1016/j.jff.2023.105565

M3 - Review article

AN - SCOPUS:85159350815

SN - 1756-4646

VL - 105

JO - Journal of Functional Foods

JF - Journal of Functional Foods

M1 - 105565

ER -

The effect of Nigella sativa (black seed) supplementation on body weight and body composition: A GRADE-assessed systematic review and dose-response meta-analysis of randomized controlled trials

Abstract

Bibliographical note

Funding

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this