The effect of Nigella sativa (black seed) supplementation on body weight and body composition: A GRADE-assessed systematic review and dose-response meta-analysis of randomized controlled trials

Navid Naghsh, Amir Hossein Moridpour, Zeynab Kavyani, Vali Musazadeh, Jaber Jafarzadeh, Ehsan Safaei, Cain C.T. Clark, Amir Hossein Faghfouri

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)
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Abstract

Many studies have suggested that Nigella Sativa supplementation may exert a beneficial effect on anthropometric indices; however, the findings are inconclusive. Therefore, this study was conducted to obtain an updated finding in this regard. Systematic search was conducted in PubMed, Cochrane Library, Web of Science, Scopus, Embase databases, and Google Scholar, up to August 2022. N. sativa supplementation significantly reduced BW (WMD = −1.46 kg; 95 % CI: −2.53, −0.39) and BMI (WMD: −0.58 kg/m2, 95 % CI: −0.86, −0.29) compared to placebo group. However, no significant reductions were found in WC (WMD: −2.54 cm, 95 % CI: −6.27, 1.19), HC (WMD: −1.92 cm; 95 % CI: −4.38 to 0.54), and WHR (WMD = −0.03; 95 % CI: −0.07, 0.01). The current meta-analysis revealed that N. sativa supplementation in adults led to a significant decrease in body weight and BMI, but not WC, HC, and WHR. Thus, according to our findings, N. sativa supplementation can be recommended as an adjunctive intervention in obesity management.

Original languageEnglish
Article number105565
Number of pages13
JournalJournal of Functional Foods
Volume105
DOIs
Publication statusPublished - 17 May 2023

Bibliographical note

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/bync-nd/4.0/).

Keywords

  • Nigella sativa
  • Body composition
  • Obesity
  • Body mass index
  • Meta-analysis

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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