The effect of Nigella sativa (black seed) supplementation on body weight and body composition: A GRADE-assessed systematic review and dose-response meta-analysis of randomized controlled trials

Navid Naghsh; Amir Hossein Moridpour; Zeynab Kavyani; Vali Musazadeh; Jaber Jafarzadeh; Ehsan Safaei; Cain C.T. Clark; Amir Hossein Faghfouri

doi:10.1016/j.jff.2023.105565

The effect of Nigella sativa (black seed) supplementation on body weight and body composition: A GRADE-assessed systematic review and dose-response meta-analysis of randomized controlled trials

Navid Naghsh, Amir Hossein Moridpour, Zeynab Kavyani, Vali Musazadeh, Jaber Jafarzadeh, Ehsan Safaei, Cain C.T. Clark, Amir Hossein Faghfouri

Centre for Healthcare and Communities

Research output: Contribution to journal › Review article › peer-review

6 Citations (Scopus)

154 Downloads (Pure)

Abstract

Many studies have suggested that Nigella Sativa supplementation may exert a beneficial effect on anthropometric indices; however, the findings are inconclusive. Therefore, this study was conducted to obtain an updated finding in this regard. Systematic search was conducted in PubMed, Cochrane Library, Web of Science, Scopus, Embase databases, and Google Scholar, up to August 2022. N. sativa supplementation significantly reduced BW (WMD = −1.46 kg; 95 % CI: −2.53, −0.39) and BMI (WMD: −0.58 kg/m², 95 % CI: −0.86, −0.29) compared to placebo group. However, no significant reductions were found in WC (WMD: −2.54 cm, 95 % CI: −6.27, 1.19), HC (WMD: −1.92 cm; 95 % CI: −4.38 to 0.54), and WHR (WMD = −0.03; 95 % CI: −0.07, 0.01). The current meta-analysis revealed that N. sativa supplementation in adults led to a significant decrease in body weight and BMI, but not WC, HC, and WHR. Thus, according to our findings, N. sativa supplementation can be recommended as an adjunctive intervention in obesity management.

Original language	English
Article number	105565
Number of pages	13
Journal	Journal of Functional Foods
Volume	105
DOIs	https://doi.org/10.1016/j.jff.2023.105565
Publication status	Published - 17 May 2023

Bibliographical note

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/bync-nd/4.0/).

Keywords

Nigella sativa
Body composition
Obesity
Body mass index
Meta-analysis

ASJC Scopus subject areas

Food Science
Medicine (miscellaneous)
Nutrition and Dietetics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jff.2023.105565Licence: CC BY-NC-ND

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Cite this

Naghsh, N., Moridpour, A. H., Kavyani, Z., Musazadeh, V., Jafarzadeh, J., Safaei, E., Clark, C. C. T., & Faghfouri, A. H. (2023). The effect of Nigella sativa (black seed) supplementation on body weight and body composition: A GRADE-assessed systematic review and dose-response meta-analysis of randomized controlled trials. Journal of Functional Foods, 105, Article 105565. https://doi.org/10.1016/j.jff.2023.105565

The effect of Nigella sativa (black seed) supplementation on body weight and body composition: A GRADE-assessed systematic review and dose-response meta-analysis of randomized controlled trials. / Naghsh, Navid; Moridpour, Amir Hossein; Kavyani, Zeynab et al.
In: Journal of Functional Foods, Vol. 105, 105565, 17.05.2023.

Research output: Contribution to journal › Review article › peer-review

Naghsh, N, Moridpour, AH, Kavyani, Z, Musazadeh, V, Jafarzadeh, J, Safaei, E, Clark, CCT & Faghfouri, AH 2023, 'The effect of Nigella sativa (black seed) supplementation on body weight and body composition: A GRADE-assessed systematic review and dose-response meta-analysis of randomized controlled trials', Journal of Functional Foods, vol. 105, 105565. https://doi.org/10.1016/j.jff.2023.105565

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abstract = "Many studies have suggested that Nigella Sativa supplementation may exert a beneficial effect on anthropometric indices; however, the findings are inconclusive. Therefore, this study was conducted to obtain an updated finding in this regard. Systematic search was conducted in PubMed, Cochrane Library, Web of Science, Scopus, Embase databases, and Google Scholar, up to August 2022. N. sativa supplementation significantly reduced BW (WMD = −1.46 kg; 95 % CI: −2.53, −0.39) and BMI (WMD: −0.58 kg/m2, 95 % CI: −0.86, −0.29) compared to placebo group. However, no significant reductions were found in WC (WMD: −2.54 cm, 95 % CI: −6.27, 1.19), HC (WMD: −1.92 cm; 95 % CI: −4.38 to 0.54), and WHR (WMD = −0.03; 95 % CI: −0.07, 0.01). The current meta-analysis revealed that N. sativa supplementation in adults led to a significant decrease in body weight and BMI, but not WC, HC, and WHR. Thus, according to our findings, N. sativa supplementation can be recommended as an adjunctive intervention in obesity management.",

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AU - Clark, Cain C.T.

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The effect of Nigella sativa (black seed) supplementation on body weight and body composition: A GRADE-assessed systematic review and dose-response meta-analysis of randomized controlled trials

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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