Abstract
to 2.66, P=0.76, I2=0.0%), or high-density lipoprotein (WMD: 0.57 mg/dl; 95% CI: -1.28 to 2.43, P=0.54, I2=68.4%). A significant reduction was observed only in serum triglyceride (TG) levels (WMD: -7.04 mg/dl; 95% CI: -11.42 to -2.67, P˂0.001, I2=0.0%). This meta-analysis concludes that L-arginine supplementation can significantly reduce blood TG levels, however, there is insufficient evidence to support its hypocholesterolaemic effects. To draw straightforward conclusions regarding generalized recommendations for L-arginine supplementation for improving lipid profile, there is a need for more well-controlled trials targeting exclusively patients with dyslipidaemia.
| Original language | English |
|---|---|
| Pages (from-to) | 1021-1032 |
| Number of pages | 12 |
| Journal | British Journal of Nutrition |
| Volume | 122 |
| Issue number | 9 |
| Early online date | 24 Jul 2019 |
| DOIs | |
| Publication status | Published - 14 Nov 2019 |
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Keywords
- L-arginine
- Lipid profile
- Meta-analysis
- Supplementation
- Systematic review
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Nutrition and Dietetics
Cite this
The effect of L-arginine supplementation on lipid profile: A systematic review and meta-analysis of randomized controlled trials. / Hadi, Amir; Arab, Arman ; Moradi, Sajjad ; Pantovic, Ana ; Clark, Cain; Ghaedi, Ehsan .
In: British Journal of Nutrition, Vol. 122, No. 9, 14.11.2019, p. 1021-1032.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The effect of L-arginine supplementation on lipid profile: A systematic review and meta-analysis of randomized controlled trials
AU - Hadi, Amir
AU - Arab, Arman
AU - Moradi, Sajjad
AU - Pantovic, Ana
AU - Clark, Cain
AU - Ghaedi, Ehsan
PY - 2019/11/14
Y1 - 2019/11/14
N2 - A number of clinical trials have examined the effect of L-arginine on lipid profile in recent years; however, the results remain equivocal. Therefore, the present study aims to summarize and quantitatively examine the available evidence on the effectiveness L-arginine supplementation on lipid parameters by employing a systematic review and meta-analytic approach. Online databases including PubMed, Scopus, ISI Web of Science, Cochrane library, and Google Scholar were searched up to April 2019 for randomized controlled trials that examined the effect of L-arginine supplementation on lipid profile in adults. Treatment effects were expressed as weighted mean difference (WMD) and the corresponding standard error (SE) in concentrations of serum lipids. To estimate the overall effect of L-arginine supplementation, we employed the random-effects model. In total, 12 studies were included in the systematic review. The meta-analysis revealed that L-arginine supplementation did not significantly change the concentrations of total cholesterol (WMD: -5.03 mg/dl; 95% CI: - 10.78 to 0.73, P= 0.08, I2=39.0%), low-density lipoprotein (WMD: -0.47 mg/dl; 95% CI: -3.61to 2.66, P=0.76, I2=0.0%), or high-density lipoprotein (WMD: 0.57 mg/dl; 95% CI: -1.28 to 2.43, P=0.54, I2=68.4%). A significant reduction was observed only in serum triglyceride (TG) levels (WMD: -7.04 mg/dl; 95% CI: -11.42 to -2.67, P˂0.001, I2=0.0%). This meta-analysis concludes that L-arginine supplementation can significantly reduce blood TG levels, however, there is insufficient evidence to support its hypocholesterolaemic effects. To draw straightforward conclusions regarding generalized recommendations for L-arginine supplementation for improving lipid profile, there is a need for more well-controlled trials targeting exclusively patients with dyslipidaemia.
AB - A number of clinical trials have examined the effect of L-arginine on lipid profile in recent years; however, the results remain equivocal. Therefore, the present study aims to summarize and quantitatively examine the available evidence on the effectiveness L-arginine supplementation on lipid parameters by employing a systematic review and meta-analytic approach. Online databases including PubMed, Scopus, ISI Web of Science, Cochrane library, and Google Scholar were searched up to April 2019 for randomized controlled trials that examined the effect of L-arginine supplementation on lipid profile in adults. Treatment effects were expressed as weighted mean difference (WMD) and the corresponding standard error (SE) in concentrations of serum lipids. To estimate the overall effect of L-arginine supplementation, we employed the random-effects model. In total, 12 studies were included in the systematic review. The meta-analysis revealed that L-arginine supplementation did not significantly change the concentrations of total cholesterol (WMD: -5.03 mg/dl; 95% CI: - 10.78 to 0.73, P= 0.08, I2=39.0%), low-density lipoprotein (WMD: -0.47 mg/dl; 95% CI: -3.61to 2.66, P=0.76, I2=0.0%), or high-density lipoprotein (WMD: 0.57 mg/dl; 95% CI: -1.28 to 2.43, P=0.54, I2=68.4%). A significant reduction was observed only in serum triglyceride (TG) levels (WMD: -7.04 mg/dl; 95% CI: -11.42 to -2.67, P˂0.001, I2=0.0%). This meta-analysis concludes that L-arginine supplementation can significantly reduce blood TG levels, however, there is insufficient evidence to support its hypocholesterolaemic effects. To draw straightforward conclusions regarding generalized recommendations for L-arginine supplementation for improving lipid profile, there is a need for more well-controlled trials targeting exclusively patients with dyslipidaemia.
KW - L-arginine
KW - Lipid profile
KW - Meta-analysis
KW - Supplementation
KW - Systematic review
UR - http://www.scopus.com/inward/record.url?scp=85069634506&partnerID=8YFLogxK
U2 - 10.1017/S0007114519001855
DO - 10.1017/S0007114519001855
M3 - Article
VL - 122
SP - 1021
EP - 1032
JO - British Journal of Nutrition
JF - British Journal of Nutrition
SN - 0007-1145
IS - 9
ER -