The Effect of Increasing Age on the Concentric and Eccentric Contractile Properties of Isolated Mouse Soleus and Extensor Digitorum Longus Muscles

Cameron Hill, Rob S James, Val M Cox, Jason Tallis

Research output: Contribution to journalArticle

5 Citations (Scopus)
17 Downloads (Pure)

Abstract

There is currently a limited amount of literature investigating the age-related changes in eccentric muscle function in vitro. The present study uniquely uses the work loop technique, to better replicate in vivo muscle function, in the assessment of the age and muscle-specific changes in acute and sustained concentric and eccentric power and recovery. Whole soleus or EDL muscles were isolated from 10-week and 78-week old mice, and acute and sustained concentric and eccentric work loop power assessed. Despite an age-related increase in body and muscle mass, peak absolute power for both muscles was unaffected by age. Peak concentric power normalised to muscle mass declined significantly for each muscle, whilst peak normalised eccentric power declined only for soleus. Fatigue resistance and recovery for the soleus did not differ between age or contraction type. Older EDL was less resistant to concentric fatigue, but was better able to withstand sustained eccentric activity than young EDL. We have shown that age-related changes in muscle quality are more limited for eccentric function than concentric function. A greater bodily inertia is likely to further reduce in vivo locomotor performance in older animals.

Original languageEnglish
Pages (from-to)579-587
JournalThe journals of gerontology. Series A, Biological sciences and medical sciences
Volume73
Issue number5
Early online date9 Dec 2017
DOIs
Publication statusPublished - 17 Apr 2018

Bibliographical note

This is a pre-copyedited, author-produced version of an article accepted for publication in Journals of Gerontology, Series A following peer review. The version of record Cameron Hill, Rob S James, Val M Cox and Jason Tallis (2018)The Effect of Increasing Age on the Concentric and Eccentric Contractile Properties of Isolated Mouse Soleus and Extensor Digitorum Longus Muscles. Journals of Gerontology, Series A (in press) is available online at: https://doi.org/10.1093/gerona/glx243

Keywords

  • fatigue
  • Muscles
  • sarcopenia
  • dynapenia
  • CD-1 mice

Fingerprint Dive into the research topics of 'The Effect of Increasing Age on the Concentric and Eccentric Contractile Properties of Isolated Mouse Soleus and Extensor Digitorum Longus Muscles'. Together they form a unique fingerprint.

Cite this