The effect of green coffee extract supplementation on serum oxidized LDL cholesterol and total antioxidant capacity in patients with dyslipidemia: a randomized, double-blind, placebo-controlled trial

Shokofeh Salamat, Saeid Sadeghian Sharif, Ali Nazary-Vanani, Hamed Kord-Varkaneh, Cain C.T. Clark, Majid Mohammadshahi

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3 Citations (Scopus)


Introduction: Previous studies on laboratory animals have evaluated the effects of CGA (chlorogenic acids)rather than GCBE (green coffee bean extract), and few studies have been conducted on human models. Thus, the purpose of the present study was to assess the effect of GCBE consumption on serum oxidized LDL-cholesterol (OX-LDL)and total antioxidant capacity (TAC)on patients with dyslipidemia. Method: In this randomized, placebo-controlled, clinical trial, 70 male participants (age range 30–55 years)were assigned from the outpatient clinic of Arvand Petrochemical Company in Mah-shahr, Ahwaz, Iran to use 800 mg/day GCBE supplements or placebo for 8 weeks. Serum TAC and OX-LDL were determined by enzyme-linked immunosorbent assay. Results: Compared with the placebo, GCBE intake led to a significant reduction in OX-LDL (−31.18 ng/ml)(P-value = <0.001)and a significant increase in TAC (71.73 μmol/l)concentration (P-value = 0.029). In the intervention group, GCBE supplementation resulted in a significant reduction in Oxidized LDL of −16.08 ± 33.30 (ng/ml)(P-value = 0.006), compared to baseline. Conclusions: The current trial showed that the intake of 800 mg per day of GCBE may have favorable effects on TAC, and OX-LDL in patients with dyslipidemia. However, further studies are required to confirm the veracity of these results.

Original languageEnglish
Pages (from-to)109-113
Number of pages5
JournalEuropean Journal of Integrative Medicine
Early online date3 May 2019
Publication statusPublished - 1 Jun 2019


Bibliographical note

NOTICE: this is the author’s version of a work that was accepted for publication in European Journal of Integrative Medicine. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in European Journal of Integrative Medicine, [In -press], (2019) DOI: 10.1016/j.eujim.2019.05.001

© 2019, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International


  • Green coffee bean extract
  • Oxidized LDL
  • Randomized control trial
  • Total antioxidant capacity

ASJC Scopus subject areas

  • Complementary and alternative medicine

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