The effect of green coffee extract supplementation on serum oxidized LDL cholesterol and total antioxidant capacity in patients with dyslipidemia: a randomized, double-blind, placebo-controlled trial

Shokofeh Salamat; Saeid Sadeghian Sharif; Ali Nazary-Vanani; Hamed Kord-Varkaneh; Cain C.T. Clark; Majid Mohammadshahi

doi:10.1016/j.eujim.2019.05.001

The effect of green coffee extract supplementation on serum oxidized LDL cholesterol and total antioxidant capacity in patients with dyslipidemia: a randomized, double-blind, placebo-controlled trial

Shokofeh Salamat, Saeid Sadeghian Sharif, Ali Nazary-Vanani, Hamed Kord-Varkaneh, Cain C.T. Clark, Majid Mohammadshahi

Research output: Contribution to journal › Article › peer-review

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Abstract

Introduction: Previous studies on laboratory animals have evaluated the effects of CGA (chlorogenic acids)rather than GCBE (green coffee bean extract), and few studies have been conducted on human models. Thus, the purpose of the present study was to assess the effect of GCBE consumption on serum oxidized LDL-cholesterol (OX-LDL)and total antioxidant capacity (TAC)on patients with dyslipidemia. Method: In this randomized, placebo-controlled, clinical trial, 70 male participants (age range 30–55 years)were assigned from the outpatient clinic of Arvand Petrochemical Company in Mah-shahr, Ahwaz, Iran to use 800 mg/day GCBE supplements or placebo for 8 weeks. Serum TAC and OX-LDL were determined by enzyme-linked immunosorbent assay. Results: Compared with the placebo, GCBE intake led to a significant reduction in OX-LDL (−31.18 ng/ml)(P-value = <0.001)and a significant increase in TAC (71.73 μmol/l)concentration (P-value = 0.029). In the intervention group, GCBE supplementation resulted in a significant reduction in Oxidized LDL of −16.08 ± 33.30 (ng/ml)(P-value = 0.006), compared to baseline. Conclusions: The current trial showed that the intake of 800 mg per day of GCBE may have favorable effects on TAC, and OX-LDL in patients with dyslipidemia. However, further studies are required to confirm the veracity of these results.

Original language	English
Pages (from-to)	109-113
Number of pages	5
Journal	European Journal of Integrative Medicine
Volume	28
Early online date	3 May 2019
DOIs	https://doi.org/10.1016/j.eujim.2019.05.001
Publication status	Published - 1 Jun 2019

Bibliographical note

NOTICE: this is the author’s version of a work that was accepted for publication in European Journal of Integrative Medicine. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in European Journal of Integrative Medicine, [In -press], (2019) DOI: 10.1016/j.eujim.2019.05.001

© 2019, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/

Keywords

Green coffee bean extract
Oxidized LDL
Randomized control trial
Total antioxidant capacity

ASJC Scopus subject areas

Complementary and alternative medicine

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10.1016/j.eujim.2019.05.001

Salamat_et_al_Effect_Green_Coffee_Extract_EJIMAccepted author manuscript, 673 KBLicence: CC BY-NC-ND

http://www.sciencedirect.com/science/article/pii/S1876382019303191

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Salamat, S., Sharif, S. S., Nazary-Vanani, A., Kord-Varkaneh, H., Clark, C. C. T., & Mohammadshahi, M. (2019). The effect of green coffee extract supplementation on serum oxidized LDL cholesterol and total antioxidant capacity in patients with dyslipidemia: a randomized, double-blind, placebo-controlled trial. European Journal of Integrative Medicine, 28, 109-113. https://doi.org/10.1016/j.eujim.2019.05.001

The effect of green coffee extract supplementation on serum oxidized LDL cholesterol and total antioxidant capacity in patients with dyslipidemia: a randomized, double-blind, placebo-controlled trial. / Salamat, Shokofeh; Sharif, Saeid Sadeghian; Nazary-Vanani, Ali et al.
In: European Journal of Integrative Medicine, Vol. 28, 01.06.2019, p. 109-113.

Research output: Contribution to journal › Article › peer-review

Salamat, S, Sharif, SS, Nazary-Vanani, A, Kord-Varkaneh, H, Clark, CCT & Mohammadshahi, M 2019, 'The effect of green coffee extract supplementation on serum oxidized LDL cholesterol and total antioxidant capacity in patients with dyslipidemia: a randomized, double-blind, placebo-controlled trial', European Journal of Integrative Medicine, vol. 28, pp. 109-113. https://doi.org/10.1016/j.eujim.2019.05.001

Salamat S, Sharif SS, Nazary-Vanani A, Kord-Varkaneh H, Clark CCT, Mohammadshahi M. The effect of green coffee extract supplementation on serum oxidized LDL cholesterol and total antioxidant capacity in patients with dyslipidemia: a randomized, double-blind, placebo-controlled trial. European Journal of Integrative Medicine. 2019 Jun 1;28:109-113. Epub 2019 May 3. doi: 10.1016/j.eujim.2019.05.001

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AU - Sharif, Saeid Sadeghian

AU - Nazary-Vanani, Ali

AU - Kord-Varkaneh, Hamed

AU - Clark, Cain C.T.

AU - Mohammadshahi, Majid

N1 - NOTICE: this is the author’s version of a work that was accepted for publication in European Journal of Integrative Medicine. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in European Journal of Integrative Medicine, [In -press], (2019) DOI: 10.1016/j.eujim.2019.05.001 © 2019, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/

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Y1 - 2019/6/1

N2 - Introduction: Previous studies on laboratory animals have evaluated the effects of CGA (chlorogenic acids)rather than GCBE (green coffee bean extract), and few studies have been conducted on human models. Thus, the purpose of the present study was to assess the effect of GCBE consumption on serum oxidized LDL-cholesterol (OX-LDL)and total antioxidant capacity (TAC)on patients with dyslipidemia. Method: In this randomized, placebo-controlled, clinical trial, 70 male participants (age range 30–55 years)were assigned from the outpatient clinic of Arvand Petrochemical Company in Mah-shahr, Ahwaz, Iran to use 800 mg/day GCBE supplements or placebo for 8 weeks. Serum TAC and OX-LDL were determined by enzyme-linked immunosorbent assay. Results: Compared with the placebo, GCBE intake led to a significant reduction in OX-LDL (−31.18 ng/ml)(P-value = <0.001)and a significant increase in TAC (71.73 μmol/l)concentration (P-value = 0.029). In the intervention group, GCBE supplementation resulted in a significant reduction in Oxidized LDL of −16.08 ± 33.30 (ng/ml)(P-value = 0.006), compared to baseline. Conclusions: The current trial showed that the intake of 800 mg per day of GCBE may have favorable effects on TAC, and OX-LDL in patients with dyslipidemia. However, further studies are required to confirm the veracity of these results.

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The effect of green coffee extract supplementation on serum oxidized LDL cholesterol and total antioxidant capacity in patients with dyslipidemia: a randomized, double-blind, placebo-controlled trial

Abstract

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