The effect of green-coffee extract supplementation on obesity: A systematic review and dose-response meta-analysis of randomized controlled trials

Zahra Gorji; Hamed Kord Varkaneh; Sam Talaei; Ali Nazary-Vannani; Cain C T Clark; Somaye Fatahi; Jamal Rahmani; Shekoufeh Salamat; Yong Zhang

doi:10.1016/j.phymed.2019.153018

The effect of green-coffee extract supplementation on obesity: A systematic review and dose-response meta-analysis of randomized controlled trials

Zahra Gorji, Hamed Kord Varkaneh, Sam Talaei, Ali Nazary-Vannani, Cain C T Clark, Somaye Fatahi, Jamal Rahmani, Shekoufeh Salamat, Yong Zhang

Research output: Contribution to journal › Review article › peer-review

31 Citations (Scopus)

140 Downloads (Pure)

Abstract

Background: Given that the most recent systematic review investigating Green-Coffee Extract (GCE) as a weight loss facilitator was nearly a decade ago and that the authors reported there no consensus on the effect of GCE/CGA (Chlorogenic acids) on body composition indices, a comprehensive systematic review and dose-response meta-analysis of all available randomized controlled trial (RCTs) was undertaken to examine the effect of GCE and CGA intervention on body weight (BW), body mass index (BMI) and waist circumference (WC) in adults. Methods: We conducted a systematic search of all available randomized controlled trials (RCTs) performed up to June 2019 in the following electronic databases: PubMed, Scopus and Google Scholar. RCTs that investigated the effect GCE/CGA Supplementation on BW, BMI and WC in adults were included for final analysis. The pooled weight mean difference (WMD) of included studies was estimated using a random-effects model. Results: A total of 13 articles with 16 RCTs were included in the meta-analysis. Results revealed significant reduction in BMI (WMD: −0.403 kg/m ², 95% CI: −0.800, −0.005, p = 0.047) and no significant change in BW (WMD: −0.585 kg, 95% CI: −1.498, 0.329, p = 0.210) and WC (WMD: −0.847 cm, 95% CI: −1.764, 0.071, p = 0.070). In the subgroup analysis, studies that were conducted on baseline BMI ≥25 kg/m ² revealed a significant greater reduction in body weight and BMI than those performed on baseline BMI <25 kg/m ². Moreover, short supplementation periods of less than 4 weeks had no effect. Conclusion: The results of current meta-analysis study support the use of GCE supplementation for the improvement of obesity indices, with sub-group analysis highlighting greater improvements in individuals with a starting BMI ≥25 kg/m ².

Original language	English
Article number	153018
Journal	Phytomedicine : international journal of phytotherapy and phytopharmacology
Volume	63
Early online date	5 Jul 2019
DOIs	https://doi.org/10.1016/j.phymed.2019.153018
Publication status	Published - Oct 2019

Bibliographical note

NOTICE: this is the author’s version of a work that was accepted for publication in Phytomedicine. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Phytomedicine, 63, (2019)] DOI: 10.1016/j.phymed.2019.153018

© 2019, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/

Keywords

BMI
Dose–response
Green-Coffee
Meta-analysis
Obesity
Weight

ASJC Scopus subject areas

Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.phymed.2019.153018

Post-PrintAccepted author manuscript, 957 KBLicence: CC BY-NC-ND

Cite this

Gorji, Z., Varkaneh, H. K., Talaei, S., Nazary-Vannani, A., Clark, C. C. T., Fatahi, S., Rahmani, J., Salamat, S., & Zhang, Y. (2019). The effect of green-coffee extract supplementation on obesity: A systematic review and dose-response meta-analysis of randomized controlled trials. Phytomedicine : international journal of phytotherapy and phytopharmacology, 63, Article 153018. Advance online publication. https://doi.org/10.1016/j.phymed.2019.153018

The effect of green-coffee extract supplementation on obesity: A systematic review and dose-response meta-analysis of randomized controlled trials. / Gorji, Zahra; Varkaneh, Hamed Kord; Talaei, Sam et al.
In: Phytomedicine : international journal of phytotherapy and phytopharmacology, Vol. 63, 153018, 10.2019.

Research output: Contribution to journal › Review article › peer-review

Gorji, Z, Varkaneh, HK, Talaei, S, Nazary-Vannani, A, Clark, CCT, Fatahi, S, Rahmani, J, Salamat, S & Zhang, Y 2019, 'The effect of green-coffee extract supplementation on obesity: A systematic review and dose-response meta-analysis of randomized controlled trials', Phytomedicine : international journal of phytotherapy and phytopharmacology, vol. 63, 153018. https://doi.org/10.1016/j.phymed.2019.153018

Gorji Z, Varkaneh HK, Talaei S, Nazary-Vannani A, Clark CCT, Fatahi S et al. The effect of green-coffee extract supplementation on obesity: A systematic review and dose-response meta-analysis of randomized controlled trials. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2019 Oct;63:153018. Epub 2019 Jul 5. doi: 10.1016/j.phymed.2019.153018

@article{fadabaa9957e4e7696d483d80f80cb6d,

title = "The effect of green-coffee extract supplementation on obesity: A systematic review and dose-response meta-analysis of randomized controlled trials",

abstract = "Background: Given that the most recent systematic review investigating Green-Coffee Extract (GCE) as a weight loss facilitator was nearly a decade ago and that the authors reported there no consensus on the effect of GCE/CGA (Chlorogenic acids) on body composition indices, a comprehensive systematic review and dose-response meta-analysis of all available randomized controlled trial (RCTs) was undertaken to examine the effect of GCE and CGA intervention on body weight (BW), body mass index (BMI) and waist circumference (WC) in adults. Methods: We conducted a systematic search of all available randomized controlled trials (RCTs) performed up to June 2019 in the following electronic databases: PubMed, Scopus and Google Scholar. RCTs that investigated the effect GCE/CGA Supplementation on BW, BMI and WC in adults were included for final analysis. The pooled weight mean difference (WMD) of included studies was estimated using a random-effects model. Results: A total of 13 articles with 16 RCTs were included in the meta-analysis. Results revealed significant reduction in BMI (WMD: −0.403 kg/m 2, 95% CI: −0.800, −0.005, p = 0.047) and no significant change in BW (WMD: −0.585 kg, 95% CI: −1.498, 0.329, p = 0.210) and WC (WMD: −0.847 cm, 95% CI: −1.764, 0.071, p = 0.070). In the subgroup analysis, studies that were conducted on baseline BMI ≥25 kg/m 2 revealed a significant greater reduction in body weight and BMI than those performed on baseline BMI <25 kg/m 2. Moreover, short supplementation periods of less than 4 weeks had no effect. Conclusion: The results of current meta-analysis study support the use of GCE supplementation for the improvement of obesity indices, with sub-group analysis highlighting greater improvements in individuals with a starting BMI ≥25 kg/m 2. ",

keywords = "BMI, Dose–response, Green-Coffee, Meta-analysis, Obesity, Weight",

author = "Zahra Gorji and Varkaneh, {Hamed Kord} and Sam Talaei and Ali Nazary-Vannani and Clark, {Cain C T} and Somaye Fatahi and Jamal Rahmani and Shekoufeh Salamat and Yong Zhang",

note = "NOTICE: this is the author{\textquoteright}s version of a work that was accepted for publication in Phytomedicine. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Phytomedicine, 63, (2019)] DOI: 10.1016/j.phymed.2019.153018 {\textcopyright} 2019, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ ",

year = "2019",

month = oct,

doi = "10.1016/j.phymed.2019.153018",

language = "English",

volume = "63",

journal = "Phytomedicine : international journal of phytotherapy and phytopharmacology",

issn = "0944-7113",

publisher = "Urban und Fischer Verlag Jena",

}

TY - JOUR

T1 - The effect of green-coffee extract supplementation on obesity

T2 - A systematic review and dose-response meta-analysis of randomized controlled trials

AU - Gorji, Zahra

AU - Varkaneh, Hamed Kord

AU - Talaei, Sam

AU - Nazary-Vannani, Ali

AU - Clark, Cain C T

AU - Fatahi, Somaye

AU - Rahmani, Jamal

AU - Salamat, Shekoufeh

AU - Zhang, Yong

N1 - NOTICE: this is the author’s version of a work that was accepted for publication in Phytomedicine. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Phytomedicine, 63, (2019)] DOI: 10.1016/j.phymed.2019.153018 © 2019, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/

PY - 2019/10

Y1 - 2019/10

N2 - Background: Given that the most recent systematic review investigating Green-Coffee Extract (GCE) as a weight loss facilitator was nearly a decade ago and that the authors reported there no consensus on the effect of GCE/CGA (Chlorogenic acids) on body composition indices, a comprehensive systematic review and dose-response meta-analysis of all available randomized controlled trial (RCTs) was undertaken to examine the effect of GCE and CGA intervention on body weight (BW), body mass index (BMI) and waist circumference (WC) in adults. Methods: We conducted a systematic search of all available randomized controlled trials (RCTs) performed up to June 2019 in the following electronic databases: PubMed, Scopus and Google Scholar. RCTs that investigated the effect GCE/CGA Supplementation on BW, BMI and WC in adults were included for final analysis. The pooled weight mean difference (WMD) of included studies was estimated using a random-effects model. Results: A total of 13 articles with 16 RCTs were included in the meta-analysis. Results revealed significant reduction in BMI (WMD: −0.403 kg/m 2, 95% CI: −0.800, −0.005, p = 0.047) and no significant change in BW (WMD: −0.585 kg, 95% CI: −1.498, 0.329, p = 0.210) and WC (WMD: −0.847 cm, 95% CI: −1.764, 0.071, p = 0.070). In the subgroup analysis, studies that were conducted on baseline BMI ≥25 kg/m 2 revealed a significant greater reduction in body weight and BMI than those performed on baseline BMI <25 kg/m 2. Moreover, short supplementation periods of less than 4 weeks had no effect. Conclusion: The results of current meta-analysis study support the use of GCE supplementation for the improvement of obesity indices, with sub-group analysis highlighting greater improvements in individuals with a starting BMI ≥25 kg/m 2.

AB - Background: Given that the most recent systematic review investigating Green-Coffee Extract (GCE) as a weight loss facilitator was nearly a decade ago and that the authors reported there no consensus on the effect of GCE/CGA (Chlorogenic acids) on body composition indices, a comprehensive systematic review and dose-response meta-analysis of all available randomized controlled trial (RCTs) was undertaken to examine the effect of GCE and CGA intervention on body weight (BW), body mass index (BMI) and waist circumference (WC) in adults. Methods: We conducted a systematic search of all available randomized controlled trials (RCTs) performed up to June 2019 in the following electronic databases: PubMed, Scopus and Google Scholar. RCTs that investigated the effect GCE/CGA Supplementation on BW, BMI and WC in adults were included for final analysis. The pooled weight mean difference (WMD) of included studies was estimated using a random-effects model. Results: A total of 13 articles with 16 RCTs were included in the meta-analysis. Results revealed significant reduction in BMI (WMD: −0.403 kg/m 2, 95% CI: −0.800, −0.005, p = 0.047) and no significant change in BW (WMD: −0.585 kg, 95% CI: −1.498, 0.329, p = 0.210) and WC (WMD: −0.847 cm, 95% CI: −1.764, 0.071, p = 0.070). In the subgroup analysis, studies that were conducted on baseline BMI ≥25 kg/m 2 revealed a significant greater reduction in body weight and BMI than those performed on baseline BMI <25 kg/m 2. Moreover, short supplementation periods of less than 4 weeks had no effect. Conclusion: The results of current meta-analysis study support the use of GCE supplementation for the improvement of obesity indices, with sub-group analysis highlighting greater improvements in individuals with a starting BMI ≥25 kg/m 2.

KW - BMI

KW - Dose–response

KW - Green-Coffee

KW - Meta-analysis

KW - Obesity

KW - Weight

UR - http://www.scopus.com/inward/record.url?scp=85070866423&partnerID=8YFLogxK

U2 - 10.1016/j.phymed.2019.153018

DO - 10.1016/j.phymed.2019.153018

M3 - Review article

C2 - 31398662

SN - 0944-7113

VL - 63

JO - Phytomedicine : international journal of phytotherapy and phytopharmacology

JF - Phytomedicine : international journal of phytotherapy and phytopharmacology

M1 - 153018

ER -

The effect of green-coffee extract supplementation on obesity: A systematic review and dose-response meta-analysis of randomized controlled trials

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this