The Effect of Green Coffee Extract Supplementation on Blood Pressure: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Baizhi Han, Ali Nazary-Vanani, Sam Talaei, Cain Clark, Jamal Rahmani, Reyhaneh Rasekhmagham, Hamed Kord Varkaneh

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1 Citation (Scopus)


Given the proliferation in studies investigating green coffee bean extract (GCBE) supplementation, the purpose of this study was to determine the efficacy and effectiveness of GCBE supplementation on indices of blood pressure. The literature search was performed in four databases, namely, PubMed/Medline, Scopus, the Cochrane Library, and Google Scholar, to identify clinical trials that examined the effects of green coffee supplements on systolic blood pressure (SBP) and diastolic blood pressure (DBP) up to February 2019. Mean change and standard deviation (SD) of the outcome measures were used to estimate the mean difference between the intervention group and the control group at follow-up. Nine studies reported SBP and DBP as an outcome measure. Results revealed significant reduction in SBP (weighted mean difference: −3.093 mmHg, 95% confidence interval [CI]: −3.914, −2.273; I 2 = 0.0%) and DBP (−2.170 mmHg, 95% CI: −2.749, −1.590; I 2= 46.5%) after green coffee supplementation with low heterogeneity among the studies. In addition, in subgroup analysis, a significant reduction in SBP and DBP in studies with hypertensive patients, green coffee dosage <400 mg, and administered for 4 weeks was identified. The results of the current meta-analysis study support the use of GCBE supplementation for the improvement of blood pressure indices, with subgroup analysis highlighting improvements in hypertensive patients.

Original languageEnglish
Pages (from-to)2918-2926
Number of pages9
JournalPhytotherapy Research
Issue number11
Early online date20 Aug 2019
Publication statusPublished - 1 Nov 2019


Bibliographical note

This is the peer reviewed version of the following article: Han, B, Nazary-Vanani, A, Talaei, S, Clark, C, Rahmani, J, Rasekhmagham, R & Varkaneh, HK 2019, 'The Effect of Green Coffee Extract Supplementation on Blood Pressure: A Systematic Review and MetaAnalysis of Randomized Controlled Trials' Phytotherapy Research, vol. 33, no. 11, pp. 2918-2926, which has been published in final form at This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self Archiving.

Copyright © and Moral Rights are retained by the author(s) and/ or other copyright owners. A copy can be downloaded for personal non-commercial research or study, without prior permission or charge. This item cannot be reproduced or quoted extensively from without first obtaining permission in writing from the copyright holder(s). The content must not be changed in any way or sold commercially in any format or medium without the formal permission of the copyright holders.


  • Meta-analysis
  • Blood Pressure
  • SBP
  • DPB
  • Green-Coffee

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