The effect of dietary total antioxidant capacity (DTAC) and Caveolin-1 gene variant interaction on cardiovascular risk factors among overweight and obese women: A cross-sectional investigation

Atieh Mirzababaei, Farideh Shiraseb, Faezeh Abaj, Reza Amiri Khosroshahi, Atefeh Tavakoli, Fariba Koohdani, Cain C.T. Clark, Khadijeh Mirzaei

    Research output: Contribution to journalArticlepeer-review

    6 Citations (Scopus)

    Abstract

    Background: Previous studies have shown that the Caveolin-1 (CAV-1) gene variant may be associated with Cardiovascular disease (CVD) risk. Moreover, dietary total antioxidant capacity (DTAC) has been shown to potentially elicit favorable effects on CVD risk. Therefore, this study sought to investigate the effect of DTAC and CAV-1 interaction on CVD risk factors. Methods: This cross-sectional study consisted of 352 women, with overweight and/or obesity, aged 18–48years from Iran. A food frequency questionnaire (FFQ), with 147 items, was used to assess dietary intake. The CAV-1 rs 3807992 and anthropometric data were measured by the PCR-RFLP method and bioelectrical impedance analysis (BIA), respectively. Serum profiles were measured by standard protocols. Participants were also divided into two groups based on DTAC score and rs3807992 genotype. Results: The mean age of the participants was 37.34 ± 9.11 and 36.01 ± 9.12 years for homozygous (GG) and minor allele carriers (AG + AA) respectively.The mean ± SD of insulin, total cholesterol (TC),high-density lipoprotein (HDL), low-density lipoprotein (LDL) and TG of participants were 1.21 ± 0.23, 185.3 ± 35.77, 46.58 ± 10.86, 95.3 ± 24.12 and 118.1 ± 58.88, respectively. There was a significant difference between genotypes for physical activity (P = 0.05), HDL (P < 0.001), insulin (P = 0.04), CRI-I (TC/HDL-C) (P = 0.01), and CRI-II (LDL-C/HDL-C) (P = 0.04). Our findings also showed, after controlling for confounding factors, significant interactions between DTAC score and the A allele carrier group on TC (Pinteraction = 0.001), LDL (Pinteraction = 0.001), insulin (Pinteraction = 0.08), HOMA-IR (Pinteraction = 0.03), AC ((TC - HDL – C)/HDL – C) (Pinteraction = 0.001), and CHOLINDEX (LDL-C-HDL-C) (Pinteraction = 0.02). Conclusion: The results of the present study indicate that high DTAC intake may modify the odds of risk factors for CVD in AA and AG genotypes of rs 3807992. These results highlight that diet, gene variants, and their interaction, should be considered in CVD risk assessment.

    Original languageEnglish
    Pages (from-to)4893-4903
    Number of pages11
    JournalClinical Nutrition
    Volume40
    Issue number8
    Early online date12 Jul 2021
    DOIs
    Publication statusPublished - Aug 2021

    Bibliographical note

    Funding Information:
    This study was supported by Tehran University of Medical Sciences (Grant number: 97-03-161-41017 ).

    Publisher Copyright:
    © 2021 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism

    Keywords

    • Cardiovascular risk factors
    • CAV-1 gene
    • Dietary total antioxidant capacity

    ASJC Scopus subject areas

    • Nutrition and Dietetics
    • Critical Care and Intensive Care Medicine

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