The Effect of Dietary Supplementation of Green Tea Catechins on Cardiovascular Disease Risk Markers in Humans: A Systematic Review of Clinical Trials

Sarah Lau, Ekavi Georgousopoulou, Jane Kellett, Jackson Thomas, Andrew McKune, Paul Roach, Duane Mellor, Nenad Naumovski

Research output: Contribution to journalReview article

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Abstract

Green tea catechins (GTCs) are secondary plant metabolites that have been associated with health benefits in human trials. As such, they have the potential to reduce cardiovascular disease (CVD) risk; however, results are not consistent. This systematic review of the published data assessed the putative effect of GTCs supplementation on anthropometric, blood pressure, and biochemical measures associated with CVD risk. It was conducted in accordance with the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines exploring four major electronic databases (MEDLINE, Cochrane Library, Web of Science, and Scopus). Studies were included if they were published in peer-reviewed journals in English from 1990 until October 2015, and were human double-blind randomized and placebo-controlled trials (RCTs). From 122,428 articles initially identified, after two levels of screening, seven studies met the inclusion criteria. The review revealed consistent and significant (p ≤ 0.05) reductions in body mass index (BMI), blood pressure and plasma lipids; however, this effect would have been less if between-group effects had been considered. The current evidence base also has considerable methodological limitations due to suboptimal statistical methods used in data analyses. Future research efforts must aim to rectify this paucity of evidence with well-designed and well-reported prospective studies.

Publisher Statement: This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
Original languageEnglish
Article number16
Number of pages15
JournalBeverages
Volume2
Issue number2
Early online date10 Jun 2016
DOIs
Publication statusPublished - 21 Jun 2016

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Catechin
Tea
Licensure
Dietary Supplements
Cardiovascular Diseases
Library Science
Clinical Trials
Blood Pressure
Insurance Benefits
MEDLINE
Meta-Analysis
Body Mass Index
Randomized Controlled Trials
Placebos
Databases
Prospective Studies
Guidelines
Lipids

Keywords

  • green tea catechins
  • GTCs
  • epigallocatechin gallate
  • EGCG
  • systematic review
  • human clinical trials
  • cardiovascular disease biomarkers

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The Effect of Dietary Supplementation of Green Tea Catechins on Cardiovascular Disease Risk Markers in Humans : A Systematic Review of Clinical Trials. / Lau, Sarah; Georgousopoulou, Ekavi; Kellett, Jane; Thomas, Jackson ; McKune, Andrew; Roach, Paul; Mellor, Duane; Naumovski, Nenad.

In: Beverages, Vol. 2, No. 2, 16, 21.06.2016.

Research output: Contribution to journalReview article

Lau, Sarah ; Georgousopoulou, Ekavi ; Kellett, Jane ; Thomas, Jackson ; McKune, Andrew ; Roach, Paul ; Mellor, Duane ; Naumovski, Nenad. / The Effect of Dietary Supplementation of Green Tea Catechins on Cardiovascular Disease Risk Markers in Humans : A Systematic Review of Clinical Trials. In: Beverages. 2016 ; Vol. 2, No. 2.
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