The effect of curcumin supplementation on circulating adiponectin: A systematic review and meta-analysis of randomized controlled trials

Cain Clark; Ehsan Ghaedi; Arman Arab; Makan Pourmasoumi; Amir Hadi

doi:10.1016/j.dsx.2019.07.045

The effect of curcumin supplementation on circulating adiponectin: A systematic review and meta-analysis of randomized controlled trials

Cain Clark, Ehsan Ghaedi, Arman Arab, Makan Pourmasoumi, Amir Hadi

Research output: Contribution to journal › Review article › peer-review

26 Citations (Scopus)

205 Downloads (Pure)

Abstract

Objective: Our objective was to perform a systematic review and meta-analysis on randomized controlled trials (RCTs) assessing the effect of curcumin on serum adiponectin concentration. Methods: We searched PubMed/Medline, Scopus, ISI Web of Science, Cochrane Library, and Google scholar databases up to April 2019. RCTs conducted among human adults studied the effects of curcumin on serum adiponectin concentrations as an outcome variable was included. The weighted mean differences (WMD) and standard deviations (SD) of change in serum adiponectin levels were calculated. The random effects model was used for deriving a summary of mean estimates with their corresponding SDs. Results: Out of 313 records, 6 trials that enrolled 652 subjects were included. The pooled results showed that curcumin supplementation significantly increased adiponectin concentrations in comparison with placebo (WMD: 0.82 Hedges' g; 95% confidence interval (CI): 0.33 to 1.30, P˂0.001). Greater effects on adiponectin were observed in trials lasting ≤10 weeks (WMD: 1.05 Hedges’ g; 95% CI: 0.64 to 1.45, P˂0.001). Conclusion: Curcumin significantly improves adiponectin concentrations. However, due to some limitations in this study, further studies are needed to reach a definitive conclusion about the effect of curcumin on the levels of adiponectin.

Original language	English
Pages (from-to)	2819-2825
Number of pages	7
Journal	Diabetes & Metabolic Syndrome: Clinical Research & Reviews
Volume	13
Issue number	5
Early online date	30 Jul 2019
DOIs	https://doi.org/10.1016/j.dsx.2019.07.045
Publication status	Published - Sept 2019

Bibliographical note

NOTICE: this is the author’s version of a work that was accepted for publication in Diabetes & Metabolic Syndrome: Clinical Research & Reviews,. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in [Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 13:5, (2019) DOI: 10.1016/j.dsx.2019.07.045

© 2019, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/

Keywords

Adiponectin
Curcumin
Meta-analysis
Randomized controlled trials

ASJC Scopus subject areas

Internal Medicine
Endocrinology, Diabetes and Metabolism

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.dsx.2019.07.045

Post-PrintAccepted author manuscript, 549 KBLicence: CC BY-NC-ND

Cite this

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title = "The effect of curcumin supplementation on circulating adiponectin: A systematic review and meta-analysis of randomized controlled trials",

abstract = "Objective: Our objective was to perform a systematic review and meta-analysis on randomized controlled trials (RCTs) assessing the effect of curcumin on serum adiponectin concentration. Methods: We searched PubMed/Medline, Scopus, ISI Web of Science, Cochrane Library, and Google scholar databases up to April 2019. RCTs conducted among human adults studied the effects of curcumin on serum adiponectin concentrations as an outcome variable was included. The weighted mean differences (WMD) and standard deviations (SD) of change in serum adiponectin levels were calculated. The random effects model was used for deriving a summary of mean estimates with their corresponding SDs. Results: Out of 313 records, 6 trials that enrolled 652 subjects were included. The pooled results showed that curcumin supplementation significantly increased adiponectin concentrations in comparison with placebo (WMD: 0.82 Hedges' g; 95% confidence interval (CI): 0.33 to 1.30, P˂0.001). Greater effects on adiponectin were observed in trials lasting ≤10 weeks (WMD: 1.05 Hedges{\textquoteright} g; 95% CI: 0.64 to 1.45, P˂0.001). Conclusion: Curcumin significantly improves adiponectin concentrations. However, due to some limitations in this study, further studies are needed to reach a definitive conclusion about the effect of curcumin on the levels of adiponectin.",

keywords = "Adiponectin, Curcumin, Meta-analysis, Randomized controlled trials",

author = "Cain Clark and Ehsan Ghaedi and Arman Arab and Makan Pourmasoumi and Amir Hadi",

note = "NOTICE: this is the author{\textquoteright}s version of a work that was accepted for publication in Diabetes & Metabolic Syndrome: Clinical Research & Reviews,. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in [Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 13:5, (2019) DOI: 10.1016/j.dsx.2019.07.045 {\textcopyright} 2019, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ ",

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T1 - The effect of curcumin supplementation on circulating adiponectin

T2 - A systematic review and meta-analysis of randomized controlled trials

AU - Clark, Cain

AU - Ghaedi, Ehsan

AU - Arab, Arman

AU - Pourmasoumi, Makan

AU - Hadi, Amir

N1 - NOTICE: this is the author’s version of a work that was accepted for publication in Diabetes & Metabolic Syndrome: Clinical Research & Reviews,. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in [Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 13:5, (2019) DOI: 10.1016/j.dsx.2019.07.045 © 2019, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/

PY - 2019/9

Y1 - 2019/9

N2 - Objective: Our objective was to perform a systematic review and meta-analysis on randomized controlled trials (RCTs) assessing the effect of curcumin on serum adiponectin concentration. Methods: We searched PubMed/Medline, Scopus, ISI Web of Science, Cochrane Library, and Google scholar databases up to April 2019. RCTs conducted among human adults studied the effects of curcumin on serum adiponectin concentrations as an outcome variable was included. The weighted mean differences (WMD) and standard deviations (SD) of change in serum adiponectin levels were calculated. The random effects model was used for deriving a summary of mean estimates with their corresponding SDs. Results: Out of 313 records, 6 trials that enrolled 652 subjects were included. The pooled results showed that curcumin supplementation significantly increased adiponectin concentrations in comparison with placebo (WMD: 0.82 Hedges' g; 95% confidence interval (CI): 0.33 to 1.30, P˂0.001). Greater effects on adiponectin were observed in trials lasting ≤10 weeks (WMD: 1.05 Hedges’ g; 95% CI: 0.64 to 1.45, P˂0.001). Conclusion: Curcumin significantly improves adiponectin concentrations. However, due to some limitations in this study, further studies are needed to reach a definitive conclusion about the effect of curcumin on the levels of adiponectin.

AB - Objective: Our objective was to perform a systematic review and meta-analysis on randomized controlled trials (RCTs) assessing the effect of curcumin on serum adiponectin concentration. Methods: We searched PubMed/Medline, Scopus, ISI Web of Science, Cochrane Library, and Google scholar databases up to April 2019. RCTs conducted among human adults studied the effects of curcumin on serum adiponectin concentrations as an outcome variable was included. The weighted mean differences (WMD) and standard deviations (SD) of change in serum adiponectin levels were calculated. The random effects model was used for deriving a summary of mean estimates with their corresponding SDs. Results: Out of 313 records, 6 trials that enrolled 652 subjects were included. The pooled results showed that curcumin supplementation significantly increased adiponectin concentrations in comparison with placebo (WMD: 0.82 Hedges' g; 95% confidence interval (CI): 0.33 to 1.30, P˂0.001). Greater effects on adiponectin were observed in trials lasting ≤10 weeks (WMD: 1.05 Hedges’ g; 95% CI: 0.64 to 1.45, P˂0.001). Conclusion: Curcumin significantly improves adiponectin concentrations. However, due to some limitations in this study, further studies are needed to reach a definitive conclusion about the effect of curcumin on the levels of adiponectin.

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KW - Curcumin

KW - Meta-analysis

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DO - 10.1016/j.dsx.2019.07.045

M3 - Review article

SN - 1871-4021

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SP - 2819

EP - 2825

JO - Diabetes & Metabolic Syndrome: Clinical Research & Reviews

JF - Diabetes & Metabolic Syndrome: Clinical Research & Reviews

IS - 5

ER -

The effect of curcumin supplementation on circulating adiponectin: A systematic review and meta-analysis of randomized controlled trials

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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