The effect of curcumin supplementation on circulating adiponectin: A systematic review and meta-analysis of randomized controlled trials

Cain Clark, Ehsan Ghaedi, Arman Arab, Makan Pourmasoumi, Amir Hadi

Research output: Contribution to journalReview articlepeer-review

3 Citations (Scopus)
29 Downloads (Pure)


Objective: Our objective was to perform a systematic review and meta-analysis on randomized controlled trials (RCTs) assessing the effect of curcumin on serum adiponectin concentration. Methods: We searched PubMed/Medline, Scopus, ISI Web of Science, Cochrane Library, and Google scholar databases up to April 2019. RCTs conducted among human adults studied the effects of curcumin on serum adiponectin concentrations as an outcome variable was included. The weighted mean differences (WMD) and standard deviations (SD) of change in serum adiponectin levels were calculated. The random effects model was used for deriving a summary of mean estimates with their corresponding SDs. Results: Out of 313 records, 6 trials that enrolled 652 subjects were included. The pooled results showed that curcumin supplementation significantly increased adiponectin concentrations in comparison with placebo (WMD: 0.82 Hedges' g; 95% confidence interval (CI): 0.33 to 1.30, P˂0.001). Greater effects on adiponectin were observed in trials lasting ≤10 weeks (WMD: 1.05 Hedges’ g; 95% CI: 0.64 to 1.45, P˂0.001). Conclusion: Curcumin significantly improves adiponectin concentrations. However, due to some limitations in this study, further studies are needed to reach a definitive conclusion about the effect of curcumin on the levels of adiponectin.

Original languageEnglish
Pages (from-to)2819-2825
Number of pages7
JournalDiabetes & Metabolic Syndrome: Clinical Research & Reviews
Issue number5
Early online date30 Jul 2019
Publication statusPublished - Sep 2019

Bibliographical note

NOTICE: this is the author’s version of a work that was accepted for publication in Diabetes & Metabolic Syndrome: Clinical Research & Reviews,. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in [Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 13:5, (2019) DOI: 10.1016/j.dsx.2019.07.045

© 2019, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International


  • Adiponectin
  • Curcumin
  • Meta-analysis
  • Randomized controlled trials

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

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