The effect of curcumin supplementation on circulating adiponectin: A systematic review and meta-analysis of randomized controlled trials

Cain Clark, Ehsan Ghaedi, Arman Arab, Makan Pourmasoumi, Amir Hadi

    Research output: Contribution to journalReview articlepeer-review

    24 Citations (Scopus)
    151 Downloads (Pure)


    Objective: Our objective was to perform a systematic review and meta-analysis on randomized controlled trials (RCTs) assessing the effect of curcumin on serum adiponectin concentration. Methods: We searched PubMed/Medline, Scopus, ISI Web of Science, Cochrane Library, and Google scholar databases up to April 2019. RCTs conducted among human adults studied the effects of curcumin on serum adiponectin concentrations as an outcome variable was included. The weighted mean differences (WMD) and standard deviations (SD) of change in serum adiponectin levels were calculated. The random effects model was used for deriving a summary of mean estimates with their corresponding SDs. Results: Out of 313 records, 6 trials that enrolled 652 subjects were included. The pooled results showed that curcumin supplementation significantly increased adiponectin concentrations in comparison with placebo (WMD: 0.82 Hedges' g; 95% confidence interval (CI): 0.33 to 1.30, P˂0.001). Greater effects on adiponectin were observed in trials lasting ≤10 weeks (WMD: 1.05 Hedges’ g; 95% CI: 0.64 to 1.45, P˂0.001). Conclusion: Curcumin significantly improves adiponectin concentrations. However, due to some limitations in this study, further studies are needed to reach a definitive conclusion about the effect of curcumin on the levels of adiponectin.

    Original languageEnglish
    Pages (from-to)2819-2825
    Number of pages7
    JournalDiabetes & Metabolic Syndrome: Clinical Research & Reviews
    Issue number5
    Early online date30 Jul 2019
    Publication statusPublished - Sept 2019

    Bibliographical note

    NOTICE: this is the author’s version of a work that was accepted for publication in Diabetes & Metabolic Syndrome: Clinical Research & Reviews,. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in [Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 13:5, (2019) DOI: 10.1016/j.dsx.2019.07.045

    © 2019, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International


    • Adiponectin
    • Curcumin
    • Meta-analysis
    • Randomized controlled trials

    ASJC Scopus subject areas

    • Internal Medicine
    • Endocrinology, Diabetes and Metabolism


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