The effect of Brazil nuts on selenium levels, Glutathione peroxidase, and thyroid hormones: A systematic review and meta-analysis of randomized controlled trials

Yingxin LI, Cain Clark, hebatullah Abdulazeem, Ammar Salehisahlabadi, Jamal Rahmani, Yong Zhang

Research output: Contribution to journalArticle

Abstract

Brazil nuts or Bertholletia excelsa provide a rich natural source of magnesium, phosphorus, and manganese. Furthermore, it is rich of anti-oxidants such as selenium, vitamin E, and phenols like gallic acid and ellagic acid and have improvement effects on plasma selenium levels, Glutathione peroxidase (GPx), and thyroid hormones but the results have not been summarized in a meta-analysis. The purpose of this study is to investigate the effect of brazil nut on plasma selenium levels, GPx, and thyroid hormones. Literature search was done in MEDLINE/PubMed, Scopus and web of sciences databases up to October 2019. Studies included that had RCTs design, use brazil nut as intervention, and reported selenium levels, Glutathione peroxidase, or thyroid hormones as outcome. PRISMA guidelines followed to perform this

meta-analysis and results combined DerSimonian and Laird random effect model. Seven studies with 315 participant’s included and in this meta-analysis. Mean duration of intervention was 11
weeks and mean dosage of brazil nut was 9.42g/day in included studies. Our study found brazil nut have significant increasing effect on plasma selenium levels (WMD:87.63 microg/l, 95%CI:36.02,139.24, I2=98%). Furthermore, Brazil nut had increasing effect on GPx levels too (WMD:8.05U/gHb,95% CI:0.65,15.45, I2=96%) but brazil nut had no significant effect on on T3 (WMD: 0.06pg/ml,95%CI:-0.50,0.39, I2=74%), T4 (WMD:-0.01pg/ml,95%CI:-0.46,0.44, I2=82%), and TSH levels (WMD:0.01ng/ml,95%CI:-0.03,0.05, I2=0.67%).The findings of this meta-analysis indicates brazil nut increase plasma selenium and GPx levels.
Original languageEnglish
Pages (from-to)(In-press)
JournalJournal of King Saud University - Computer and Information Sciences
Volume(In-press)
Publication statusAccepted/In press - 15 Jan 2020

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Selenium
Plasmas
Ellagic acid
Vitamins
Oxidants
Phenols
Manganese
Magnesium
Phosphorus
Glutathione
Thyroid Hormones
Acids

Bibliographical note

Listed in DOAJ

Cite this

The effect of Brazil nuts on selenium levels, Glutathione peroxidase, and thyroid hormones : A systematic review and meta-analysis of randomized controlled trials. / LI, Yingxin ; Clark, Cain; Abdulazeem, hebatullah; Salehisahlabadi, Ammar ; Rahmani, Jamal; Zhang, Yong.

In: Journal of King Saud University - Computer and Information Sciences, Vol. (In-press), 15.01.2020, p. (In-press).

Research output: Contribution to journalArticle

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abstract = "Brazil nuts or Bertholletia excelsa provide a rich natural source of magnesium, phosphorus, and manganese. Furthermore, it is rich of anti-oxidants such as selenium, vitamin E, and phenols like gallic acid and ellagic acid and have improvement effects on plasma selenium levels, Glutathione peroxidase (GPx), and thyroid hormones but the results have not been summarized in a meta-analysis. The purpose of this study is to investigate the effect of brazil nut on plasma selenium levels, GPx, and thyroid hormones. Literature search was done in MEDLINE/PubMed, Scopus and web of sciences databases up to October 2019. Studies included that had RCTs design, use brazil nut as intervention, and reported selenium levels, Glutathione peroxidase, or thyroid hormones as outcome. PRISMA guidelines followed to perform thismeta-analysis and results combined DerSimonian and Laird random effect model. Seven studies with 315 participant’s included and in this meta-analysis. Mean duration of intervention was 11weeks and mean dosage of brazil nut was 9.42g/day in included studies. Our study found brazil nut have significant increasing effect on plasma selenium levels (WMD:87.63 microg/l, 95{\%}CI:36.02,139.24, I2=98{\%}). Furthermore, Brazil nut had increasing effect on GPx levels too (WMD:8.05U/gHb,95{\%} CI:0.65,15.45, I2=96{\%}) but brazil nut had no significant effect on on T3 (WMD: 0.06pg/ml,95{\%}CI:-0.50,0.39, I2=74{\%}), T4 (WMD:-0.01pg/ml,95{\%}CI:-0.46,0.44, I2=82{\%}), and TSH levels (WMD:0.01ng/ml,95{\%}CI:-0.03,0.05, I2=0.67{\%}).The findings of this meta-analysis indicates brazil nut increase plasma selenium and GPx levels.",
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AU - Salehisahlabadi, Ammar

AU - Rahmani, Jamal

AU - Zhang, Yong

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