Methods: Several online medical databases were systematically searched up to February 2019. All clinical trials exploring the effects of berberine supplementation on indices of obesity were included. The combined weighted mean difference (WMD) of eligible studies was assessed using a random-effects model. We evaluated publication bias by using the Egger’s test.
Results: Overall, 10 studies were included. The combined outcomes suggested a significant
influence of berberine administration on body mass index (BMI) (WMD: -0.29 kg/m2, 95% CI: - 0.51 to -0.08, p = 0.006) and waist circumference (WC) (WMD: -2.75 cm, 95% CI: -4.88 to -0.62, p = 0.01). However, berberine supplementation yielded no significant decline in body weight (BW) (WMD: -0.11 kg, 95% CI: -0.99 to 0.76, p = 0.79). Following the dose-response evaluation, berberine intake was found to significantly reduce BMI (r = -0.02) and WC (r = -0.72) based on treatment duration.
Conclusion: The results of the current study support the use of berberine supplementation for the improvement of obesity indices.
- Body mass index
- Body weight
ASJC Scopus subject areas
- Complementary and alternative medicine