Abstract
Background and purpose: Clinical studies investigating the effects of berberine supplementation on anthropometric indices in humans have generated inconsistent results. Thus, the objective of this systematic review and meta-analysis was to clarify the effects of berberine supplementation on obesity indices in human subjects.
Methods: Several online medical databases were systematically searched up to February 2019. All clinical trials exploring the effects of berberine supplementation on indices of obesity were included. The combined weighted mean difference (WMD) of eligible studies was assessed using a random-effects model. We evaluated publication bias by using the Egger’s test.
Results: Overall, 10 studies were included. The combined outcomes suggested a significant
influence of berberine administration on body mass index (BMI) (WMD: -0.29 kg/m2, 95% CI: - 0.51 to -0.08, p = 0.006) and waist circumference (WC) (WMD: -2.75 cm, 95% CI: -4.88 to -0.62, p = 0.01). However, berberine supplementation yielded no significant decline in body weight (BW) (WMD: -0.11 kg, 95% CI: -0.99 to 0.76, p = 0.79). Following the dose-response evaluation, berberine intake was found to significantly reduce BMI (r = -0.02) and WC (r = -0.72) based on treatment duration.
Conclusion: The results of the current study support the use of berberine supplementation for the improvement of obesity indices.
Methods: Several online medical databases were systematically searched up to February 2019. All clinical trials exploring the effects of berberine supplementation on indices of obesity were included. The combined weighted mean difference (WMD) of eligible studies was assessed using a random-effects model. We evaluated publication bias by using the Egger’s test.
Results: Overall, 10 studies were included. The combined outcomes suggested a significant
influence of berberine administration on body mass index (BMI) (WMD: -0.29 kg/m2, 95% CI: - 0.51 to -0.08, p = 0.006) and waist circumference (WC) (WMD: -2.75 cm, 95% CI: -4.88 to -0.62, p = 0.01). However, berberine supplementation yielded no significant decline in body weight (BW) (WMD: -0.11 kg, 95% CI: -0.99 to 0.76, p = 0.79). Following the dose-response evaluation, berberine intake was found to significantly reduce BMI (r = -0.02) and WC (r = -0.72) based on treatment duration.
Conclusion: The results of the current study support the use of berberine supplementation for the improvement of obesity indices.
| Original language | English |
|---|---|
| Article number | 101113 |
| Journal | Complementary Therapies in Clinical Practice |
| Volume | 39 |
| Early online date | 1 Feb 2020 |
| DOIs | |
| Publication status | Published - May 2020 |
Bibliographical note
NOTICE: this is the author’s version of a work that was accepted for publication in Complementary Therapies in Clinical Practice. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Complementary Therapies in Clinical Practice, 39, (2020)DOI: 10.1016/j.ctcp.2020.101113
© 2020, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
Keywords
- Berberine
- Body mass index
- Body weight
- Dose–response
- Meta-analysis
- Obesity
ASJC Scopus subject areas
- Complementary and alternative medicine
