The effect of Aronia consumption on lipid profile, blood pressure, and biomarkers of inflammation: a systematic review and meta-analysis of randomized controlled trials

Jamal Rahmani, Cain Clark, Hamed Kord Varkaneh, Theophilus Lakiang, Lenny T. Vasanthan, V Onyeche, Seyyed Mohammad Mousavi, Y. Zhang

Research output: Contribution to journalReview article

Abstract

Plant derivatives, such as anthocyanin-rich phytochemicals, have been reported to elicit a positive effect on lipid profile. Therefore, the aim of this study was to systematically review and meta-analyze the effects of Aronia consumption on lipid profiles, blood pressure, and biomarkers of inflammation in randomized controlled trials. A systematic search was performed in PubMed/MEDLINE, Cochrane, and SCOPUS up to December 2018. Seven studies were identified and analyzed in this meta-analysis. Our study found a significant increase in high-density lipoprotein (HDL; weighted mean difference [WMD]: 1.48 mg/dl, 95% confidence interval, CI, [1.29, 1.68]) and diastolic blood pressure (WMD: 2.55 mmHg, 95% CI [0.63, 4.47]) following Aronia consumption. There was no significant effect on systolic blood pressure and C-reactive protein, tumor necrosis factor, and interleukin-1. Furthermore, subgroup analysis showed that cholesterol (WMD: −7.18, 95% CI [−13.90, −0.46]) and low-density lipoprotein (LDL; WMD: −5.84, 95% CI [−6.91, −4.77]) decreased more significantly in interventions less than 10 weeks in duration. Dose–response analysis demonstrated a significant reduction in triglyceride levels when dose of Aronia was increased to 300 mg/day. In conclusion, the results demonstrated a significant increase in HDL and reduction in total cholesterol and LDL among patients supplementing with Aronia.

Original languageEnglish
Pages (from-to)1981-1990
Number of pages10
JournalPhytotherapy Research
Volume33
Issue number8
Early online date24 Jun 2019
DOIs
Publication statusPublished - Aug 2019

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Photinia
Meta-Analysis
Randomized Controlled Trials
Biomarkers
Blood Pressure
Inflammation
Lipids
Anthocyanins
Phytochemicals
HDL Lipoproteins
Interleukin-1
LDL Lipoproteins
PubMed
MEDLINE
C-Reactive Protein
LDL Cholesterol
Triglycerides
Tumor Necrosis Factor-alpha
Cholesterol
Confidence Intervals

Keywords

  • Aronia
  • Chokeberry
  • Blood Pressure
  • Triglyceride
  • Cholesterol
  • CRP

Cite this

The effect of Aronia consumption on lipid profile, blood pressure, and biomarkers of inflammation : a systematic review and meta-analysis of randomized controlled trials. / Rahmani, Jamal; Clark, Cain; Varkaneh, Hamed Kord ; Lakiang, Theophilus ; Vasanthan, Lenny T. ; Onyeche, V; Mousavi, Seyyed Mohammad; Zhang, Y.

In: Phytotherapy Research, Vol. 33, No. 8, 08.2019, p. 1981-1990.

Research output: Contribution to journalReview article

Rahmani, Jamal ; Clark, Cain ; Varkaneh, Hamed Kord ; Lakiang, Theophilus ; Vasanthan, Lenny T. ; Onyeche, V ; Mousavi, Seyyed Mohammad ; Zhang, Y. / The effect of Aronia consumption on lipid profile, blood pressure, and biomarkers of inflammation : a systematic review and meta-analysis of randomized controlled trials. In: Phytotherapy Research. 2019 ; Vol. 33, No. 8. pp. 1981-1990.
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abstract = "Plant derivatives, such as anthocyanin-rich phytochemicals, have been reported to elicit a positive effect on lipid profile. Therefore, the aim of this study was to systematically review and meta-analyze the effects of Aronia consumption on lipid profiles, blood pressure, and biomarkers of inflammation in randomized controlled trials. A systematic search was performed in PubMed/MEDLINE, Cochrane, and SCOPUS up to December 2018. Seven studies were identified and analyzed in this meta-analysis. Our study found a significant increase in high-density lipoprotein (HDL; weighted mean difference [WMD]: 1.48 mg/dl, 95{\%} confidence interval, CI, [1.29, 1.68]) and diastolic blood pressure (WMD: 2.55 mmHg, 95{\%} CI [0.63, 4.47]) following Aronia consumption. There was no significant effect on systolic blood pressure and C-reactive protein, tumor necrosis factor, and interleukin-1. Furthermore, subgroup analysis showed that cholesterol (WMD: −7.18, 95{\%} CI [−13.90, −0.46]) and low-density lipoprotein (LDL; WMD: −5.84, 95{\%} CI [−6.91, −4.77]) decreased more significantly in interventions less than 10 weeks in duration. Dose–response analysis demonstrated a significant reduction in triglyceride levels when dose of Aronia was increased to 300 mg/day. In conclusion, the results demonstrated a significant increase in HDL and reduction in total cholesterol and LDL among patients supplementing with Aronia.",
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