The effect of a physiological concentration of caffeine on the endurance of maximally and submaximally stimulated mouse soleus muscle

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    18 Citations (Scopus)

    Abstract

    The use of caffeine as an ergogenic aid to promote endurance has been widely studied, with human literature showing the greatest benefit during submaximal muscle activities. Recent evidence suggests that the acute treatment of skeletal muscle with physiological concentrations of caffeine (70 μM maximum) will directly potentiate force production. The aims of the present study are: firstly, to assess the effects of a physiological concentration (70 μM) of caffeine on endurance in maximally activated mouse soleus (relatively slow) muscle; and secondly, to examine whether endurance changes when muscle is activated submaximally during caffeine treatment. Maximally stimulated soleus muscle treated with 70 μM caffeine resulted in a significant (17.6 %) decrease in endurance. In contrast, at a submaximal stimulation frequency, caffeine treatment significantly prolonged endurance (by 19.2 %). Findings are activation-dependent such that, during high frequency stimulation, caffeine accelerates fatigue, whereas, during low frequency stimulation, caffeine delays fatigue.
    Original languageEnglish
    Pages (from-to)125-132
    JournalJournal of Physiological Sciences
    Volume63
    Issue number2
    DOIs
    Publication statusPublished - 2013

    Bibliographical note

    The full text of this item is not available from the repository.
    The final publication is available at www.springerlink.com.

    Keywords

    • activation level
    • endurance
    • ergogenic aid
    • isolated muscle
    • power
    • skeletal muscle
    • work loop

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