The effect of 8 weeks of combined interval (resistance-interval training) and combined endurance (endurance-resistance training) on plasma levels of adropin and nitric oxide in males with high blood pressure

Maryam Salmanpour, Rahman Soori, Cyrine H’mida, Jamel Halouani, Cain T. Clarck, Parisa Pournemati, Sajjad Mohammad Yari, Khaled Trabelsi, Achraf Ammar, Hamdi Chtourou, Morteza Taheri

    Research output: Contribution to journalArticlepeer-review

    1 Citation (Scopus)

    Abstract

    Introduction: Nitric oxide (NO) is a vasodilator that plays an important role in blood pressure control. The purpose of the present study was to compare the effect of 8 weeks of resistance-interval and endurance-resistance trainings on plasma levels of adropin and NO in males with hypertension. Method: Forty-five patients with hypertension were recruited and divided into 3 groups of control (age = 51.1 ± 6.4 years, body mass = 80.4 ± 9.2 kg), resistance-interval training (age = 50.7 ± 5.5 years, body mass = 78.1 ± 11 kg), and endurance-resistance training (age = 52.8 ± 6.1 years, body mass = 79.6 ± 9.2 kg). The resistance training program was performed in 2 sets, 10 to 15 repetitions, with 50% intensity of one repetition maximum. Increasing endurance training was performed for 30–40 min at 60–70% of maximum heart rate (HRmax) on the bike. The high-intensity interval training program consisted of 4 intervals of 80 to 90% of HRmax and 3-min recovery periods of 60 to 70% of HRmax. Blood samples were collected 1 week before the start of the training program and 48 h after the last training session. Plasma levels of adropin and nitrite/nitrate were measured by ELISA before and after the exercise interventions. Results: Eight weeks of resistance-interval and endurance-resistance trainings increased plasma levels of adropin and NO and decreased blood pressure (P ≤ 0.05). Furthermore, plasma levels of adropin increased in both exercise groups, whereas NO levels increased only in the endurance-resistance training. Systolic blood pressure decreased in the resistance-interval training (P ≤ 0.05) while it remained unchanged in the endurance-resistance group. Conclusion: Resistance-interval and endurance-resistance trainings are effective in decreasing blood pressure by increasing cardiorespiratory capacity and plasma levels of adropin and NO.

    Original languageEnglish
    Pages (from-to)2559-2568
    Number of pages10
    JournalIrish Journal of Medical Science
    Volume191
    Early online date14 Jan 2022
    DOIs
    Publication statusPublished - Dec 2022

    Bibliographical note

    Publisher Copyright:
    © 2022, The Author(s), under exclusive licence to Royal Academy of Medicine in Ireland.

    Keywords

    • Adropin
    • High-intensity interval training
    • Hypertension
    • Nitric oxide

    ASJC Scopus subject areas

    • Medicine(all)

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