Abstract
Objective: To determine the origin and dynamic characteristics of the generalised hyper-synchronous spike and wave (SW) discharges in childhood absence epilepsy (CAE). Methods: We applied nonlinear methods, the error reduction ratio (ERR) causality test and cross-frequency analysis, with a nonlinear autoregressive exogenous (NARX) model, to electroencephalograms (EEGs) from CAE, selected with stringent electro-clinical criteria (17 cases, 42 absences). We analysed the pre-ictal and ictal strength of association between homologous and heterologous EEG derivations and estimated the direction of synchronisation and corresponding time lags. Results: A frontal/fronto-central onset of the absences is detected in 13 of the 17 cases with the highest ictal strength of association between homologous frontal followed by centro-temporal and fronto-central areas. Delays consistently in excess of 4 ms occur at the very onset between these regions, swiftly followed by the emergence of “isochronous” (0–2 ms) synchronisation but dynamic time lag changes occur during SW discharges. Conclusions: In absences an initial cortico-cortical spread leads to dynamic lag changes to include periods of isochronous interhemispheric synchronisation, which we hypothesize is mediated by the thalamus. Significance: Absences from CAE show ictal epileptic network dynamics remarkably similar to those observed in WAG/Rij rats which guided the formulation of the cortical focus theory.
Original language | English |
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Pages (from-to) | 602-617 |
Number of pages | 16 |
Journal | Clinical Neurophysiology |
Volume | 129 |
Issue number | 3 |
Early online date | 8 Jan 2018 |
DOIs | |
Publication status | Published - 1 Mar 2018 |
Externally published | Yes |
Keywords
- Absence
- Cortical focus theory
- ERR causality test
- Nonlinear
- Thalamus
- Zero-Lag
ASJC Scopus subject areas
- Sensory Systems
- Neurology
- Clinical Neurology
- Physiology (medical)
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Profiles
-
Fei He
- Faculty Research Centre for Data Science - Assistant Professor (Academic)
Person: Teaching and Research