The binding of nonintercalative drugs to alternating DNA sequences

F. Gago, C.A. Reynolds, W.G. Richards

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Molecular mechanics methods have been applied to suggest possible models for netropsin and related compounds binding to two different sequences of DNA, namely poly[d(AT)].poly[d(AT)] and poly[d(GC)].poly[d(GC)], and to evaluate the different contributions to the binding affinities of these compounds in the ethidium displacement assay. The geometries found after energy refinement suggest that one of the reasons for the selectivity of binding of these agents to A + T-rich DNA regions could be the different widths of the minor groove of the double strand of DNA found in the complexes of these drugs with both DNA sequences.
Original languageEnglish
Pages (from-to)232-241
Number of pages10
JournalMolecular Pharmacology
Volume35
Issue number2
Publication statusPublished - 1 Feb 1989

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