The association of appetite and hormones (leptin, ghrelin, and Insulin) with resting metabolic rate in overweight/ obese women: a case–control study

Sara Hajishizari; Hossein Imani; Sanaz Mehranfar; Mir Saeed Yekaninejad; Atieh Mirzababaei; Cain C.T. Clark; Khadijeh Mirzaei

doi:10.1186/s40795-022-00531-w

The association of appetite and hormones (leptin, ghrelin, and Insulin) with resting metabolic rate in overweight/ obese women: a case–control study

Sara Hajishizari, Hossein Imani, Sanaz Mehranfar, Mir Saeed Yekaninejad, Atieh Mirzababaei, Cain C.T. Clark, Khadijeh Mirzaei

Tehran University of Medical Sciences

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

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Abstract

Abstract: Objective: Low resting metabolic rate (RMR), as a risk factor for weight gain and obesity, can be influenced by many factors. Empirical research has confirmed the role of appetite and related hormones in obesity and energy intake. This study aimed to investigate the relationship between appetite and related hormones in overweight or obese Iranian women with normal and hypo RMR. Methods: This case–control study was conducted on 42 Iranian adult women (21 cases, and 21 controls), aged 18–48 years. An impedance body analyzer was used to obtain the body composition and an indirect calorimeter was used to assess the RMR. The Flint questionnaire was used to assess appetite, dietary intake, and physical activity were assessed by FFQ and IPAQ questionnaires respectively, and ELISA kits were used to assess leptin, ghrelin, and insulin hormones. Results: The results of the study demonstrated a negative association between ghrelin hormone level (β = -0.34, 95%CI = -61.70,-3.86, P-value = 0.027) and RMR, and a positive association between insulin hormone level (β = 0.48, 95%CI = 9.38–34.35, P-value = 0.001) and RMR. Also, results of the appetite questionnaire showed that, in general, both appetite (β = 0.32, 95%CI = -0.10–2.99 P-value = 0.044) and hunger variable (β = 0.30, 95%CI = 0.04–5.87, P-value = 0.047) have a positive association with RMR. There was no significant association between leptin levels and RMR. Conclusion: It is evident that appetite and related hormones have a potential role in promoting a normal RMR.

Original language	English
Article number	37
Number of pages	12
Journal	BMC Nutrition
Volume	8
Issue number	1
Early online date	29 Apr 2022
DOIs	https://doi.org/10.1186/s40795-022-00531-w https://doi.org/10.1186/s40795-022-00531-w
Publication status	Published - Dec 2022

Bibliographical note

© The Author(s) 2022. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativeco mmons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

Keywords

Research
Energy expenditure
Obesity
Resting metabolic rate
Appetite
Ghrelin
Leptin
Insulin

ASJC Scopus subject areas

Medicine (miscellaneous)
Endocrinology, Diabetes and Metabolism
Nutrition and Dietetics
Public Health, Environmental and Occupational Health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1186/s40795-022-00531-wLicence: CC0
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Cite this

Hajishizari, S., Imani, H., Mehranfar, S., Saeed Yekaninejad, M., Mirzababaei, A., Clark, C. C. T., & Mirzaei, K. (2022). The association of appetite and hormones (leptin, ghrelin, and Insulin) with resting metabolic rate in overweight/ obese women: a case–control study. BMC Nutrition, 8(1), Article 37. https://doi.org/10.1186/s40795-022-00531-w, https://doi.org/10.1186/s40795-022-00531-w

Hajishizari, S, Imani, H, Mehranfar, S, Saeed Yekaninejad, M, Mirzababaei, A, Clark, CCT & Mirzaei, K 2022, 'The association of appetite and hormones (leptin, ghrelin, and Insulin) with resting metabolic rate in overweight/ obese women: a case–control study', BMC Nutrition, vol. 8, no. 1, 37. https://doi.org/10.1186/s40795-022-00531-w, https://doi.org/10.1186/s40795-022-00531-w

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AU - Hajishizari, Sara

AU - Imani, Hossein

AU - Mehranfar, Sanaz

AU - Saeed Yekaninejad, Mir

AU - Mirzababaei, Atieh

AU - Clark, Cain C.T.

AU - Mirzaei, Khadijeh

N1 - © The Author(s) 2022. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativeco mmons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PY - 2022/12

Y1 - 2022/12

N2 - Abstract: Objective: Low resting metabolic rate (RMR), as a risk factor for weight gain and obesity, can be influenced by many factors. Empirical research has confirmed the role of appetite and related hormones in obesity and energy intake. This study aimed to investigate the relationship between appetite and related hormones in overweight or obese Iranian women with normal and hypo RMR. Methods: This case–control study was conducted on 42 Iranian adult women (21 cases, and 21 controls), aged 18–48 years. An impedance body analyzer was used to obtain the body composition and an indirect calorimeter was used to assess the RMR. The Flint questionnaire was used to assess appetite, dietary intake, and physical activity were assessed by FFQ and IPAQ questionnaires respectively, and ELISA kits were used to assess leptin, ghrelin, and insulin hormones. Results: The results of the study demonstrated a negative association between ghrelin hormone level (β = -0.34, 95%CI = -61.70,-3.86, P-value = 0.027) and RMR, and a positive association between insulin hormone level (β = 0.48, 95%CI = 9.38–34.35, P-value = 0.001) and RMR. Also, results of the appetite questionnaire showed that, in general, both appetite (β = 0.32, 95%CI = -0.10–2.99 P-value = 0.044) and hunger variable (β = 0.30, 95%CI = 0.04–5.87, P-value = 0.047) have a positive association with RMR. There was no significant association between leptin levels and RMR. Conclusion: It is evident that appetite and related hormones have a potential role in promoting a normal RMR.

AB - Abstract: Objective: Low resting metabolic rate (RMR), as a risk factor for weight gain and obesity, can be influenced by many factors. Empirical research has confirmed the role of appetite and related hormones in obesity and energy intake. This study aimed to investigate the relationship between appetite and related hormones in overweight or obese Iranian women with normal and hypo RMR. Methods: This case–control study was conducted on 42 Iranian adult women (21 cases, and 21 controls), aged 18–48 years. An impedance body analyzer was used to obtain the body composition and an indirect calorimeter was used to assess the RMR. The Flint questionnaire was used to assess appetite, dietary intake, and physical activity were assessed by FFQ and IPAQ questionnaires respectively, and ELISA kits were used to assess leptin, ghrelin, and insulin hormones. Results: The results of the study demonstrated a negative association between ghrelin hormone level (β = -0.34, 95%CI = -61.70,-3.86, P-value = 0.027) and RMR, and a positive association between insulin hormone level (β = 0.48, 95%CI = 9.38–34.35, P-value = 0.001) and RMR. Also, results of the appetite questionnaire showed that, in general, both appetite (β = 0.32, 95%CI = -0.10–2.99 P-value = 0.044) and hunger variable (β = 0.30, 95%CI = 0.04–5.87, P-value = 0.047) have a positive association with RMR. There was no significant association between leptin levels and RMR. Conclusion: It is evident that appetite and related hormones have a potential role in promoting a normal RMR.

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KW - Energy expenditure

KW - Obesity

KW - Resting metabolic rate

KW - Appetite

KW - Ghrelin

KW - Leptin

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ER -

The association of appetite and hormones (leptin, ghrelin, and Insulin) with resting metabolic rate in overweight/ obese women: a case–control study

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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