The association between urinary metabolites of polycyclic aromatic hydrocarbons (PAHs) and cardiovascular diseases and blood pressure: a systematic review and meta-analysis of observational studies

Atieh Mirzababaei, Elnaz Daneshzad, Sajjad Moradi, Faezeh Abaj, Sanaz Mehranfar, Omid Asbaghi, Cain C.T. Clark, Khadijeh Mirzaei

    Research output: Contribution to journalReview articlepeer-review

    11 Citations (Scopus)

    Abstract

    Although epidemiological studies have discerned the association between polycyclic aromatic hydrocarbons (PAHs) exposure and hypertension and/or cardiovascular disease in the general population, the possible mechanisms for this association are not well understood. We sought to examine the association between urinary metabolites of PAHs and cardiovascular diseases (CVDs) and blood pressure in adults, by conducting a meta-analysis of observational studies. We searched PubMed, Scopus, Embase, and Web of science, up to July 2021, for observational studies that investigated the association between urinary metabolites of PAHs and CVDs and blood pressure in adults. Nine prospective studies, including 27,280 participants, were included. Based on overall pooled results, there was a significant positive association between all types of urinary metabolites of PAH and blood pressure (OR: 1.32; 95%, CI: 1.19 to 1.48, p < 0.0001) (I2 = 62.4%, p < 0.0001). There was no significant association between any urinary metabolite of PAH and CHD (OR: 0.93; 95%, CI: 0.83 to 1.03, p = 0.174) (I2 = 0%, p = 0.653). Overall, there was a significant positive association between all urinary metabolites of PAH and CVD (OR: 1.23; 95%, CI: 1.16 to 1.30, p < 0.0001) (I2 = 59.7%, p < 0.0001). The results of the present meta-analysis suggest that different metabolites PAHs are associated with an increased risk of CVD and HTN. Further studies, including randomized clinical trials, are needed to confirm the veracity of our findings.

    Original languageEnglish
    Pages (from-to)1712-1728
    Number of pages17
    JournalEnvironmental Science and Pollution Research
    Volume29
    Issue number2
    Early online date26 Oct 2021
    DOIs
    Publication statusPublished - Jan 2022

    Bibliographical note

    Funding Information:
    We thank the School of Nutritional and Dietetics at Tehran University of Medical Sciences and participants in this investigation.

    Publisher Copyright:
    © 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

    Keywords

    • Blood pressure
    • Cardiovascular disease
    • Coronary heart disease
    • Polycyclic aromatic hydrocarbons

    ASJC Scopus subject areas

    • Environmental Chemistry
    • Pollution
    • Health, Toxicology and Mutagenesis

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