The Association between Smoking Cessation and HbA1c Control of Diabetes Mellitus: A THIN database study

Linda Nichols, Amanda Farley, Mohammed Mohammed, Tim Coleman, Andrew Farmer, Deborah Lycett, Ronan Ryan, Andrew Roalfe, Lisa Szatkowski, Richard W. Morris, Paul Aveyard

Research output: Contribution to conferencePoster

Abstract

Itroduction Preliminary evidence suggests control of diabetes deteriorates initially after stopping smoking. Our objective was to examine whether smoking cessation was associated with deterioration in diabetes control. Methods A retrospective cohort study (01/01/05-31/12/10) was conducted using The Health Improvement Network (THIN) database, which is representative of the UK population. Inclusion criteria were: patients aged over 18, registered with their practice for at least one year on 01/01/05, diagnosed with type 2 diabetes mellitus (T2DM) and whose last recorded smoking status before 2005 was current smoker. An adjusted multilevel regression model was developed to investigate the association between change in HbA1c and stopping smoking. Results 10,692 adults with T2DM were current smokers at 1st January 2005. Of these, 3,131 (29%) quit smoking and remained abstinent for one year or longer. After adjustment for potential confounders, patients who quit smoking had a mean post-quit increase in HbA1c of 2.3mmol/l (95% CI 1.91 to 2.77, p<0.001) that persisted for three years. The deterioration was not mediated by weight gain. Discussion Smoking cessation is associated with deterioration in glycaemic control in people with type 2 diabetes that persists for three years and appears not to be caused by weight gain. The rise in HbA1c is minor for each patient and clinician but will substantially increase microvascular complications in the whole population, which could be prevented by prompt action to improve glycaemic control on cessation.
Original languageEnglish
DOIs
Publication statusPublished - 2014
EventNIHR School for Primary Care Research Showcase - Oxford, United Kingdom
Duration: 26 Sep 201426 Sep 2014
https://www.nihr.ac.uk/events/nihr-school-for-primary-care-research-(spcr)-showcase/1344

Conference

ConferenceNIHR School for Primary Care Research Showcase
Abbreviated titleSPCR
CountryUnited Kingdom
CityOxford
Period26/09/1426/09/14
Internet address

Fingerprint

Smoking Cessation
Diabetes Mellitus
Smoking
Databases
Type 2 Diabetes Mellitus
Health
Weight Gain
Population
Cohort Studies
Retrospective Studies

Cite this

Nichols, L., Farley, A., Mohammed, M., Coleman, T., Farmer, A., Lycett, D., ... Aveyard, P. (2014). The Association between Smoking Cessation and HbA1c Control of Diabetes Mellitus: A THIN database study. Poster session presented at NIHR School for Primary Care Research Showcase, Oxford, United Kingdom. https://doi.org/10.13140/2.1.3258.1125

The Association between Smoking Cessation and HbA1c Control of Diabetes Mellitus: A THIN database study. / Nichols, Linda; Farley, Amanda; Mohammed, Mohammed ; Coleman, Tim; Farmer, Andrew; Lycett, Deborah; Ryan, Ronan; Roalfe, Andrew; Szatkowski, Lisa; Morris, Richard W.; Aveyard, Paul.

2014. Poster session presented at NIHR School for Primary Care Research Showcase, Oxford, United Kingdom.

Research output: Contribution to conferencePoster

Nichols, L, Farley, A, Mohammed, M, Coleman, T, Farmer, A, Lycett, D, Ryan, R, Roalfe, A, Szatkowski, L, Morris, RW & Aveyard, P 2014, 'The Association between Smoking Cessation and HbA1c Control of Diabetes Mellitus: A THIN database study' NIHR School for Primary Care Research Showcase, Oxford, United Kingdom, 26/09/14 - 26/09/14, . https://doi.org/10.13140/2.1.3258.1125
Nichols L, Farley A, Mohammed M, Coleman T, Farmer A, Lycett D et al. The Association between Smoking Cessation and HbA1c Control of Diabetes Mellitus: A THIN database study. 2014. Poster session presented at NIHR School for Primary Care Research Showcase, Oxford, United Kingdom. https://doi.org/10.13140/2.1.3258.1125
Nichols, Linda ; Farley, Amanda ; Mohammed, Mohammed ; Coleman, Tim ; Farmer, Andrew ; Lycett, Deborah ; Ryan, Ronan ; Roalfe, Andrew ; Szatkowski, Lisa ; Morris, Richard W. ; Aveyard, Paul. / The Association between Smoking Cessation and HbA1c Control of Diabetes Mellitus: A THIN database study. Poster session presented at NIHR School for Primary Care Research Showcase, Oxford, United Kingdom.
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title = "The Association between Smoking Cessation and HbA1c Control of Diabetes Mellitus: A THIN database study",
abstract = "Itroduction Preliminary evidence suggests control of diabetes deteriorates initially after stopping smoking. Our objective was to examine whether smoking cessation was associated with deterioration in diabetes control. Methods A retrospective cohort study (01/01/05-31/12/10) was conducted using The Health Improvement Network (THIN) database, which is representative of the UK population. Inclusion criteria were: patients aged over 18, registered with their practice for at least one year on 01/01/05, diagnosed with type 2 diabetes mellitus (T2DM) and whose last recorded smoking status before 2005 was current smoker. An adjusted multilevel regression model was developed to investigate the association between change in HbA1c and stopping smoking. Results 10,692 adults with T2DM were current smokers at 1st January 2005. Of these, 3,131 (29{\%}) quit smoking and remained abstinent for one year or longer. After adjustment for potential confounders, patients who quit smoking had a mean post-quit increase in HbA1c of 2.3mmol/l (95{\%} CI 1.91 to 2.77, p<0.001) that persisted for three years. The deterioration was not mediated by weight gain. Discussion Smoking cessation is associated with deterioration in glycaemic control in people with type 2 diabetes that persists for three years and appears not to be caused by weight gain. The rise in HbA1c is minor for each patient and clinician but will substantially increase microvascular complications in the whole population, which could be prevented by prompt action to improve glycaemic control on cessation.",
author = "Linda Nichols and Amanda Farley and Mohammed Mohammed and Tim Coleman and Andrew Farmer and Deborah Lycett and Ronan Ryan and Andrew Roalfe and Lisa Szatkowski and Morris, {Richard W.} and Paul Aveyard",
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AU - Nichols, Linda

AU - Farley, Amanda

AU - Mohammed, Mohammed

AU - Coleman, Tim

AU - Farmer, Andrew

AU - Lycett, Deborah

AU - Ryan, Ronan

AU - Roalfe, Andrew

AU - Szatkowski, Lisa

AU - Morris, Richard W.

AU - Aveyard, Paul

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N2 - Itroduction Preliminary evidence suggests control of diabetes deteriorates initially after stopping smoking. Our objective was to examine whether smoking cessation was associated with deterioration in diabetes control. Methods A retrospective cohort study (01/01/05-31/12/10) was conducted using The Health Improvement Network (THIN) database, which is representative of the UK population. Inclusion criteria were: patients aged over 18, registered with their practice for at least one year on 01/01/05, diagnosed with type 2 diabetes mellitus (T2DM) and whose last recorded smoking status before 2005 was current smoker. An adjusted multilevel regression model was developed to investigate the association between change in HbA1c and stopping smoking. Results 10,692 adults with T2DM were current smokers at 1st January 2005. Of these, 3,131 (29%) quit smoking and remained abstinent for one year or longer. After adjustment for potential confounders, patients who quit smoking had a mean post-quit increase in HbA1c of 2.3mmol/l (95% CI 1.91 to 2.77, p<0.001) that persisted for three years. The deterioration was not mediated by weight gain. Discussion Smoking cessation is associated with deterioration in glycaemic control in people with type 2 diabetes that persists for three years and appears not to be caused by weight gain. The rise in HbA1c is minor for each patient and clinician but will substantially increase microvascular complications in the whole population, which could be prevented by prompt action to improve glycaemic control on cessation.

AB - Itroduction Preliminary evidence suggests control of diabetes deteriorates initially after stopping smoking. Our objective was to examine whether smoking cessation was associated with deterioration in diabetes control. Methods A retrospective cohort study (01/01/05-31/12/10) was conducted using The Health Improvement Network (THIN) database, which is representative of the UK population. Inclusion criteria were: patients aged over 18, registered with their practice for at least one year on 01/01/05, diagnosed with type 2 diabetes mellitus (T2DM) and whose last recorded smoking status before 2005 was current smoker. An adjusted multilevel regression model was developed to investigate the association between change in HbA1c and stopping smoking. Results 10,692 adults with T2DM were current smokers at 1st January 2005. Of these, 3,131 (29%) quit smoking and remained abstinent for one year or longer. After adjustment for potential confounders, patients who quit smoking had a mean post-quit increase in HbA1c of 2.3mmol/l (95% CI 1.91 to 2.77, p<0.001) that persisted for three years. The deterioration was not mediated by weight gain. Discussion Smoking cessation is associated with deterioration in glycaemic control in people with type 2 diabetes that persists for three years and appears not to be caused by weight gain. The rise in HbA1c is minor for each patient and clinician but will substantially increase microvascular complications in the whole population, which could be prevented by prompt action to improve glycaemic control on cessation.

U2 - 10.13140/2.1.3258.1125

DO - 10.13140/2.1.3258.1125

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