The association between smoking cessation and glycaemic control in patients with type 2 diabetes: a THIN database cohort study

Deborah Lycett; L. Nichols; R. Ryan; A. Farley; A. Roalfe; M. Mohammed; L. Szatkowski; T. Coleman; R. Morris; A. Farmer; P. Aveyard

doi:10.1016/S2213-8587(15)00082-0

The association between smoking cessation and glycaemic control in patients with type 2 diabetes: a THIN database cohort study

Deborah Lycett
, L. Nichols
, R. Ryan
, A. Farley
, A. Roalfe
, M. Mohammed
, L. Szatkowski
, T. Coleman
, R. Morris
, A. Farmer
, P. Aveyard

National Institute for Health and Care Research
University of Birmingham
University of Bradford
University of Nottingham
University of Bristol
University of Oxford

Research output: Contribution to journal › Article › peer-review

84 Citations (Scopus)

287 Downloads (Pure)

Abstract

Background: Smoking increases the risk of developing type 2 diabetes. However, several population studies also show a higher risk in people 3–5 years after smoking cessation than in continuing smokers. After 10–12 years the risk equates to that of never-smokers. Small cohort studies suggest diabetes control deteriorates temporarily during the first year after quitting. We examined whether or not quitting smoking was associated with altered diabetes control in a population study, for how long this association persisted, and whether or not this association was mediated by weight change. Methods: We did a retrospective cohort study (Jan 1, 2005, to Dec 31, 2010) of adult smokers with type 2 diabetes using The Health Improvement Network (THIN), a large UK primary care database. We developed adjusted multilevel regression models to investigate the association between a quit event, smoking abstinence duration, change in HbA1c, and the mediating effect of weight change. Findings: 10 692 adult smokers with type 2 diabetes were included. 3131 (29%) quit smoking and remained abstinent for at least 1 year. After adjustment for potential confounders, HbA1c increased by 0·21% (95% CI 0·17–0·25; p

Original language	English
Pages (from-to)	423-430
Number of pages	8
Journal	The Lancet Diabetes & Endocrinology
Volume	3
Issue number	6
Early online date	29 Apr 2015
DOIs	https://doi.org/10.1016/S2213-8587(15)00082-0
Publication status	Published - Jun 2015

Bibliographical note

NOTICE: this is the author's version of a work that was accepted for publication in The Lancet Diabetes and Endocrinology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in http://www.thelancet.com/journals/landia/article/PIIS2213-8587(15)00082-0/abstract. © 2015, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

smoking cessation
diabetes
glycaemic control

Access to Document

10.1016/S2213-8587(15)00082-0

Smoking cessation and glycaemic controlAccepted author manuscript, 565 KBLicence: CC BY-NC-ND

http://www.thelancet.com/journals/landia/issue/current

Professor Deborah Lycett, PhD
- Centre for Healthcare and Community Transformation - Associate Pro-Vice-Chancellor (Research and Enterprise), Affiliate
Person: Other, Teaching and Research

Cite this

Lycett, D., Nichols, L., Ryan, R., Farley, A., Roalfe, A., Mohammed, M., Szatkowski, L., Coleman, T., Morris, R., Farmer, A., & Aveyard, P. (2015). The association between smoking cessation and glycaemic control in patients with type 2 diabetes: a THIN database cohort study. The Lancet Diabetes & Endocrinology, 3(6), 423-430. https://doi.org/10.1016/S2213-8587(15)00082-0

Lycett, D, Nichols, L, Ryan, R, Farley, A, Roalfe, A, Mohammed, M, Szatkowski, L, Coleman, T, Morris, R, Farmer, A & Aveyard, P 2015, 'The association between smoking cessation and glycaemic control in patients with type 2 diabetes: a THIN database cohort study', The Lancet Diabetes & Endocrinology, vol. 3, no. 6, pp. 423-430. https://doi.org/10.1016/S2213-8587(15)00082-0

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abstract = "Background: Smoking increases the risk of developing type 2 diabetes. However, several population studies also show a higher risk in people 3–5 years after smoking cessation than in continuing smokers. After 10–12 years the risk equates to that of never-smokers. Small cohort studies suggest diabetes control deteriorates temporarily during the first year after quitting. We examined whether or not quitting smoking was associated with altered diabetes control in a population study, for how long this association persisted, and whether or not this association was mediated by weight change. Methods: We did a retrospective cohort study (Jan 1, 2005, to Dec 31, 2010) of adult smokers with type 2 diabetes using The Health Improvement Network (THIN), a large UK primary care database. We developed adjusted multilevel regression models to investigate the association between a quit event, smoking abstinence duration, change in HbA1c, and the mediating effect of weight change. Findings: 10 692 adult smokers with type 2 diabetes were included. 3131 (29\%) quit smoking and remained abstinent for at least 1 year. After adjustment for potential confounders, HbA1c increased by 0·21\% (95\% CI 0·17–0·25; p",

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AU - Ryan, R.

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AU - Roalfe, A.

AU - Mohammed, M.

AU - Szatkowski, L.

AU - Coleman, T.

AU - Morris, R.

AU - Farmer, A.

AU - Aveyard, P.

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N2 - Background: Smoking increases the risk of developing type 2 diabetes. However, several population studies also show a higher risk in people 3–5 years after smoking cessation than in continuing smokers. After 10–12 years the risk equates to that of never-smokers. Small cohort studies suggest diabetes control deteriorates temporarily during the first year after quitting. We examined whether or not quitting smoking was associated with altered diabetes control in a population study, for how long this association persisted, and whether or not this association was mediated by weight change. Methods: We did a retrospective cohort study (Jan 1, 2005, to Dec 31, 2010) of adult smokers with type 2 diabetes using The Health Improvement Network (THIN), a large UK primary care database. We developed adjusted multilevel regression models to investigate the association between a quit event, smoking abstinence duration, change in HbA1c, and the mediating effect of weight change. Findings: 10 692 adult smokers with type 2 diabetes were included. 3131 (29%) quit smoking and remained abstinent for at least 1 year. After adjustment for potential confounders, HbA1c increased by 0·21% (95% CI 0·17–0·25; p

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KW - glycaemic control

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The association between smoking cessation and glycaemic control in patients with type 2 diabetes: a THIN database cohort study

Abstract

Bibliographical note

UN SDGs

Keywords

Access to Document

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Professor Deborah Lycett, PhD

Cite this