The association between smoking cessation and glycaemic control in patients with type 2 diabetes: a THIN database cohort study

Deborah Lycett, L. Nichols, R. Ryan, A. Farley, A. Roalfe, M. Mohammed, L. Szatkowski, T. Coleman, R. Morris, A. Farmer, P. Aveyard

Research output: Contribution to journalArticle

42 Citations (Scopus)
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Abstract

Background: Smoking increases the risk of developing type 2 diabetes. However, several population studies also show a higher risk in people 3–5 years after smoking cessation than in continuing smokers. After 10–12 years the risk equates to that of never-smokers. Small cohort studies suggest diabetes control deteriorates temporarily during the first year after quitting. We examined whether or not quitting smoking was associated with altered diabetes control in a population study, for how long this association persisted, and whether or not this association was mediated by weight change. Methods: We did a retrospective cohort study (Jan 1, 2005, to Dec 31, 2010) of adult smokers with type 2 diabetes using The Health Improvement Network (THIN), a large UK primary care database. We developed adjusted multilevel regression models to investigate the association between a quit event, smoking abstinence duration, change in HbA1c, and the mediating effect of weight change. Findings: 10 692 adult smokers with type 2 diabetes were included. 3131 (29%) quit smoking and remained abstinent for at least 1 year. After adjustment for potential confounders, HbA1c increased by 0·21% (95% CI 0·17–0·25; p
Original languageEnglish
Pages (from-to)423-430
Number of pages8
JournalThe Lancet Diabetes & Endocrinology
Volume3
Issue number6
DOIs
Publication statusPublished - Jun 2015

Bibliographical note

NOTICE: this is the author's version of a work that was accepted for publication in The Lancet Diabetes and Endocrinology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in http://www.thelancet.com/journals/landia/article/PIIS2213-8587(15)00082-0/abstract. © 2015, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/

Keywords

  • smoking cessation
  • diabetes
  • glycaemic control

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