The association between adult attained height and sitting height with mortality in the European prospective investigation into cancer and nutrition (EPIC)

Norie Sawada, Petra A. Wark, Melissa A. Merritt, Shoichiro Tsugane, Heather A. Ward, Sabina Rinaldi, Elisabete Weiderpass, Laureen Dartois, Mathilde His, Marie Christine Boutron-Ruault, Renée Turzanski-Fortner, Rudolf Kaaks, Kim Overvad, María Luisa Redondo, Noemie Travier, Elena Molina-Portillo, Miren Dorronsoro, Lluis Cirera, Eva Ardanaz, Aurora Perez-Cornago & 16 others Antonia Trichopoulou, Pagona Lagiou, Elissavet Valanou, Giovanna Masala, Valeria Pala, Petra H. M. Peeters, Yvonne T. Van Der Schouw, Olle Melander, Jonas Manjer, Marisa Da Silva, Guri Skeie, Anne Tjønneland, Anja Olsen, Marc J. Gunter, Elio Riboli, Amanda J. Cross

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    Abstract

    Adult height and sitting height may reflect genetic and environmental factors, including early life nutrition, physical and social environments. Previous studies have reported divergent associations for height and chronic disease mortality, with positive associations observed for cancer mortality but inverse associations for circulatory disease mortality. Sitting height might be more strongly associated with insulin resistance; however, data on sitting height and mortality is sparse. Using the European Prospective Investigation into Cancer and Nutrition study, a prospective cohort of 409,748 individuals, we examined adult height and sitting height in relation to all-cause and cause-specific mortality. Height was measured in the majority of participants; sitting height was measured in 253,000 participants. During an average of 12.5 years of follow-up, 29,810 deaths (11,931 from cancer and 7,346 from circulatory disease) were identified. Hazard ratios (HR) with 95% confidence intervals (CI) for death were calculated using multivariable Cox regression within quintiles of height. Height was positively associated with cancer mortality (men: Q5.svQ1 = 1.11, 95%CI = 1.00-1.24; women: Q5.svQ1 = 1.17, 95%CI = 1.07-1.28). In contrast, height was inversely associated with circulatory disease mortality (men: Q5.svQ1 = 0.63, 95%CI = 0.56-0.71; women: vs.1Q= 0.81, 95%CI = 0.70-0.93). Although sitting height was not associated with cancer mortality, it was inversely associated with circulatory disease (men: Q5.svQ1 = 0.64, 95%CI = 0.55-0.75; women: vs.1Q= 0.60, 95%CI = 0.49-0.74) and respiratory disease mortality (men: Q5.svQ1 = 0.45, 95%CI = 0.28-0.71; women: vs.1Q= 0.60, 95%CI = 0.40-0.89). We observed opposing effects of height on cancer and circulatory disease mortality. Sitting height was inversely associated with circulatory disease and respiratory disease mortality.

    Original languageEnglish
    Article numbere0173117
    JournalPLoS ONE
    Volume12
    Issue number3
    DOIs
    Publication statusPublished - 1 Mar 2017

    Fingerprint

    Nutrition
    nutrition
    neoplasms
    Mortality
    Confidence Intervals
    confidence interval
    Neoplasms
    Pulmonary diseases
    respiratory tract diseases
    Hazards
    Social Environment
    Insulin
    death
    Insulin Resistance
    social environment
    Chronic Disease
    prospective studies
    chronic diseases
    insulin resistance
    Prospective Studies

    ASJC Scopus subject areas

    • Medicine(all)
    • Biochemistry, Genetics and Molecular Biology(all)
    • Agricultural and Biological Sciences(all)

    Cite this

    The association between adult attained height and sitting height with mortality in the European prospective investigation into cancer and nutrition (EPIC). / Sawada, Norie; Wark, Petra A.; Merritt, Melissa A.; Tsugane, Shoichiro; Ward, Heather A.; Rinaldi, Sabina; Weiderpass, Elisabete; Dartois, Laureen; His, Mathilde; Boutron-Ruault, Marie Christine; Turzanski-Fortner, Renée; Kaaks, Rudolf; Overvad, Kim; Redondo, María Luisa; Travier, Noemie; Molina-Portillo, Elena; Dorronsoro, Miren; Cirera, Lluis; Ardanaz, Eva; Perez-Cornago, Aurora; Trichopoulou, Antonia; Lagiou, Pagona; Valanou, Elissavet; Masala, Giovanna; Pala, Valeria; Peeters, Petra H. M.; Van Der Schouw, Yvonne T.; Melander, Olle; Manjer, Jonas; Silva, Marisa Da; Skeie, Guri; Tjønneland, Anne; Olsen, Anja; Gunter, Marc J.; Riboli, Elio; Cross, Amanda J.

    In: PLoS ONE, Vol. 12, No. 3, e0173117, 01.03.2017.

    Research output: Contribution to journalArticle

    Sawada, N, Wark, PA, Merritt, MA, Tsugane, S, Ward, HA, Rinaldi, S, Weiderpass, E, Dartois, L, His, M, Boutron-Ruault, MC, Turzanski-Fortner, R, Kaaks, R, Overvad, K, Redondo, ML, Travier, N, Molina-Portillo, E, Dorronsoro, M, Cirera, L, Ardanaz, E, Perez-Cornago, A, Trichopoulou, A, Lagiou, P, Valanou, E, Masala, G, Pala, V, Peeters, PHM, Van Der Schouw, YT, Melander, O, Manjer, J, Silva, MD, Skeie, G, Tjønneland, A, Olsen, A, Gunter, MJ, Riboli, E & Cross, AJ 2017, 'The association between adult attained height and sitting height with mortality in the European prospective investigation into cancer and nutrition (EPIC)' PLoS ONE, vol. 12, no. 3, e0173117. https://doi.org/10.1371/journal.pone.0173117
    Sawada, Norie ; Wark, Petra A. ; Merritt, Melissa A. ; Tsugane, Shoichiro ; Ward, Heather A. ; Rinaldi, Sabina ; Weiderpass, Elisabete ; Dartois, Laureen ; His, Mathilde ; Boutron-Ruault, Marie Christine ; Turzanski-Fortner, Renée ; Kaaks, Rudolf ; Overvad, Kim ; Redondo, María Luisa ; Travier, Noemie ; Molina-Portillo, Elena ; Dorronsoro, Miren ; Cirera, Lluis ; Ardanaz, Eva ; Perez-Cornago, Aurora ; Trichopoulou, Antonia ; Lagiou, Pagona ; Valanou, Elissavet ; Masala, Giovanna ; Pala, Valeria ; Peeters, Petra H. M. ; Van Der Schouw, Yvonne T. ; Melander, Olle ; Manjer, Jonas ; Silva, Marisa Da ; Skeie, Guri ; Tjønneland, Anne ; Olsen, Anja ; Gunter, Marc J. ; Riboli, Elio ; Cross, Amanda J. / The association between adult attained height and sitting height with mortality in the European prospective investigation into cancer and nutrition (EPIC). In: PLoS ONE. 2017 ; Vol. 12, No. 3.
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    abstract = "Adult height and sitting height may reflect genetic and environmental factors, including early life nutrition, physical and social environments. Previous studies have reported divergent associations for height and chronic disease mortality, with positive associations observed for cancer mortality but inverse associations for circulatory disease mortality. Sitting height might be more strongly associated with insulin resistance; however, data on sitting height and mortality is sparse. Using the European Prospective Investigation into Cancer and Nutrition study, a prospective cohort of 409,748 individuals, we examined adult height and sitting height in relation to all-cause and cause-specific mortality. Height was measured in the majority of participants; sitting height was measured in 253,000 participants. During an average of 12.5 years of follow-up, 29,810 deaths (11,931 from cancer and 7,346 from circulatory disease) were identified. Hazard ratios (HR) with 95{\%} confidence intervals (CI) for death were calculated using multivariable Cox regression within quintiles of height. Height was positively associated with cancer mortality (men: Q5.svQ1 = 1.11, 95{\%}CI = 1.00-1.24; women: Q5.svQ1 = 1.17, 95{\%}CI = 1.07-1.28). In contrast, height was inversely associated with circulatory disease mortality (men: Q5.svQ1 = 0.63, 95{\%}CI = 0.56-0.71; women: vs.1Q= 0.81, 95{\%}CI = 0.70-0.93). Although sitting height was not associated with cancer mortality, it was inversely associated with circulatory disease (men: Q5.svQ1 = 0.64, 95{\%}CI = 0.55-0.75; women: vs.1Q= 0.60, 95{\%}CI = 0.49-0.74) and respiratory disease mortality (men: Q5.svQ1 = 0.45, 95{\%}CI = 0.28-0.71; women: vs.1Q= 0.60, 95{\%}CI = 0.40-0.89). We observed opposing effects of height on cancer and circulatory disease mortality. Sitting height was inversely associated with circulatory disease and respiratory disease mortality.",
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    T1 - The association between adult attained height and sitting height with mortality in the European prospective investigation into cancer and nutrition (EPIC)

    AU - Sawada, Norie

    AU - Wark, Petra A.

    AU - Merritt, Melissa A.

    AU - Tsugane, Shoichiro

    AU - Ward, Heather A.

    AU - Rinaldi, Sabina

    AU - Weiderpass, Elisabete

    AU - Dartois, Laureen

    AU - His, Mathilde

    AU - Boutron-Ruault, Marie Christine

    AU - Turzanski-Fortner, Renée

    AU - Kaaks, Rudolf

    AU - Overvad, Kim

    AU - Redondo, María Luisa

    AU - Travier, Noemie

    AU - Molina-Portillo, Elena

    AU - Dorronsoro, Miren

    AU - Cirera, Lluis

    AU - Ardanaz, Eva

    AU - Perez-Cornago, Aurora

    AU - Trichopoulou, Antonia

    AU - Lagiou, Pagona

    AU - Valanou, Elissavet

    AU - Masala, Giovanna

    AU - Pala, Valeria

    AU - Peeters, Petra H. M.

    AU - Van Der Schouw, Yvonne T.

    AU - Melander, Olle

    AU - Manjer, Jonas

    AU - Silva, Marisa Da

    AU - Skeie, Guri

    AU - Tjønneland, Anne

    AU - Olsen, Anja

    AU - Gunter, Marc J.

    AU - Riboli, Elio

    AU - Cross, Amanda J.

    PY - 2017/3/1

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    N2 - Adult height and sitting height may reflect genetic and environmental factors, including early life nutrition, physical and social environments. Previous studies have reported divergent associations for height and chronic disease mortality, with positive associations observed for cancer mortality but inverse associations for circulatory disease mortality. Sitting height might be more strongly associated with insulin resistance; however, data on sitting height and mortality is sparse. Using the European Prospective Investigation into Cancer and Nutrition study, a prospective cohort of 409,748 individuals, we examined adult height and sitting height in relation to all-cause and cause-specific mortality. Height was measured in the majority of participants; sitting height was measured in 253,000 participants. During an average of 12.5 years of follow-up, 29,810 deaths (11,931 from cancer and 7,346 from circulatory disease) were identified. Hazard ratios (HR) with 95% confidence intervals (CI) for death were calculated using multivariable Cox regression within quintiles of height. Height was positively associated with cancer mortality (men: Q5.svQ1 = 1.11, 95%CI = 1.00-1.24; women: Q5.svQ1 = 1.17, 95%CI = 1.07-1.28). In contrast, height was inversely associated with circulatory disease mortality (men: Q5.svQ1 = 0.63, 95%CI = 0.56-0.71; women: vs.1Q= 0.81, 95%CI = 0.70-0.93). Although sitting height was not associated with cancer mortality, it was inversely associated with circulatory disease (men: Q5.svQ1 = 0.64, 95%CI = 0.55-0.75; women: vs.1Q= 0.60, 95%CI = 0.49-0.74) and respiratory disease mortality (men: Q5.svQ1 = 0.45, 95%CI = 0.28-0.71; women: vs.1Q= 0.60, 95%CI = 0.40-0.89). We observed opposing effects of height on cancer and circulatory disease mortality. Sitting height was inversely associated with circulatory disease and respiratory disease mortality.

    AB - Adult height and sitting height may reflect genetic and environmental factors, including early life nutrition, physical and social environments. Previous studies have reported divergent associations for height and chronic disease mortality, with positive associations observed for cancer mortality but inverse associations for circulatory disease mortality. Sitting height might be more strongly associated with insulin resistance; however, data on sitting height and mortality is sparse. Using the European Prospective Investigation into Cancer and Nutrition study, a prospective cohort of 409,748 individuals, we examined adult height and sitting height in relation to all-cause and cause-specific mortality. Height was measured in the majority of participants; sitting height was measured in 253,000 participants. During an average of 12.5 years of follow-up, 29,810 deaths (11,931 from cancer and 7,346 from circulatory disease) were identified. Hazard ratios (HR) with 95% confidence intervals (CI) for death were calculated using multivariable Cox regression within quintiles of height. Height was positively associated with cancer mortality (men: Q5.svQ1 = 1.11, 95%CI = 1.00-1.24; women: Q5.svQ1 = 1.17, 95%CI = 1.07-1.28). In contrast, height was inversely associated with circulatory disease mortality (men: Q5.svQ1 = 0.63, 95%CI = 0.56-0.71; women: vs.1Q= 0.81, 95%CI = 0.70-0.93). Although sitting height was not associated with cancer mortality, it was inversely associated with circulatory disease (men: Q5.svQ1 = 0.64, 95%CI = 0.55-0.75; women: vs.1Q= 0.60, 95%CI = 0.49-0.74) and respiratory disease mortality (men: Q5.svQ1 = 0.45, 95%CI = 0.28-0.71; women: vs.1Q= 0.60, 95%CI = 0.40-0.89). We observed opposing effects of height on cancer and circulatory disease mortality. Sitting height was inversely associated with circulatory disease and respiratory disease mortality.

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