The activation of the CGRP receptor

James Barwell; Mark Wheatley; Alex C. Conner; Bruck Taddese; Shabana Vohra; Christopher A. Reynolds; David R. Poyner

doi:10.1042/BST20120251

The activation of the CGRP receptor

James Barwell
, Mark Wheatley
, Alex C. Conner
, Bruck Taddese
, Shabana Vohra
, Christopher A. Reynolds
, David R. Poyner

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

The CGRP (calcitonin gene-related peptide) receptor is a family B GPCR (G-protein-coupled receptor). It consists of a GPCR, CLR (calcitonin receptor-like receptor) and an accessory protein, RAMP1 (receptor activity modifying protein 1). RAMP1 is needed for CGRP binding and also cell-surface expression of CLR. CLR is an example of a family B GPCR. Unlike family A GPCRs, little is known about how these receptors are activated by their endogenous ligands. This review considers what is known about the activation of family B GPCRs and then considers how this might be applied to CLR, particularly in light of new knowledge of the crystal structures of family A GPCRs.

Original language	English
Pages (from-to)	180-184
Number of pages	5
Journal	Biochemical Society Transactions
Volume	41
Issue number	1
DOIs	https://doi.org/10.1042/BST20120251
Publication status	Published - 1 Feb 2013
Externally published	Yes

Keywords

Alanine scan
Family A GPCRs
Family B GPCRs
Mutagenesis
Secretin-like GPCR
Structure-activity relationship

ASJC Scopus subject areas

Biochemistry

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10.1042/BST20120251

Cite this

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title = "The activation of the CGRP receptor",

abstract = "The CGRP (calcitonin gene-related peptide) receptor is a family B GPCR (G-protein-coupled receptor). It consists of a GPCR, CLR (calcitonin receptor-like receptor) and an accessory protein, RAMP1 (receptor activity modifying protein 1). RAMP1 is needed for CGRP binding and also cell-surface expression of CLR. CLR is an example of a family B GPCR. Unlike family A GPCRs, little is known about how these receptors are activated by their endogenous ligands. This review considers what is known about the activation of family B GPCRs and then considers how this might be applied to CLR, particularly in light of new knowledge of the crystal structures of family A GPCRs.",

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AU - Barwell, James

AU - Wheatley, Mark

AU - Conner, Alex C.

AU - Taddese, Bruck

AU - Vohra, Shabana

AU - Reynolds, Christopher A.

AU - Poyner, David R.

PY - 2013/2/1

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N2 - The CGRP (calcitonin gene-related peptide) receptor is a family B GPCR (G-protein-coupled receptor). It consists of a GPCR, CLR (calcitonin receptor-like receptor) and an accessory protein, RAMP1 (receptor activity modifying protein 1). RAMP1 is needed for CGRP binding and also cell-surface expression of CLR. CLR is an example of a family B GPCR. Unlike family A GPCRs, little is known about how these receptors are activated by their endogenous ligands. This review considers what is known about the activation of family B GPCRs and then considers how this might be applied to CLR, particularly in light of new knowledge of the crystal structures of family A GPCRs.

AB - The CGRP (calcitonin gene-related peptide) receptor is a family B GPCR (G-protein-coupled receptor). It consists of a GPCR, CLR (calcitonin receptor-like receptor) and an accessory protein, RAMP1 (receptor activity modifying protein 1). RAMP1 is needed for CGRP binding and also cell-surface expression of CLR. CLR is an example of a family B GPCR. Unlike family A GPCRs, little is known about how these receptors are activated by their endogenous ligands. This review considers what is known about the activation of family B GPCRs and then considers how this might be applied to CLR, particularly in light of new knowledge of the crystal structures of family A GPCRs.

KW - Alanine scan

KW - Family A GPCRs

KW - Family B GPCRs

KW - Mutagenesis

KW - Secretin-like GPCR

KW - Structure-activity relationship

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DO - 10.1042/BST20120251

M3 - Article

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SP - 180

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JO - Biochemical Society Transactions

JF - Biochemical Society Transactions

IS - 1

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The activation of the CGRP receptor

Abstract

Keywords

ASJC Scopus subject areas

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