The activation of the CGRP receptor

James Barwell; Mark Wheatley; Alex C. Conner; Bruck Taddese; Shabana Vohra; Christopher A. Reynolds; David R. Poyner

doi:10.1042/BST20120251

The activation of the CGRP receptor

James Barwell, Mark Wheatley, Alex C. Conner, Bruck Taddese, Shabana Vohra, Christopher A. Reynolds, David R. Poyner

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

The CGRP (calcitonin gene-related peptide) receptor is a family B GPCR (G-protein-coupled receptor). It consists of a GPCR, CLR (calcitonin receptor-like receptor) and an accessory protein, RAMP1 (receptor activity modifying protein 1). RAMP1 is needed for CGRP binding and also cell-surface expression of CLR. CLR is an example of a family B GPCR. Unlike family A GPCRs, little is known about how these receptors are activated by their endogenous ligands. This review considers what is known about the activation of family B GPCRs and then considers how this might be applied to CLR, particularly in light of new knowledge of the crystal structures of family A GPCRs.

Original language	English
Pages (from-to)	180-184
Number of pages	5
Journal	Biochemical Society Transactions
Volume	41
Issue number	1
DOIs	https://doi.org/10.1042/BST20120251
Publication status	Published - 1 Feb 2013
Externally published	Yes

Keywords

Alanine scan
Family A GPCRs
Family B GPCRs
Mutagenesis
Secretin-like GPCR
Structure-activity relationship

ASJC Scopus subject areas

Biochemistry

Access to Document

10.1042/BST20120251

Cite this

@article{9f74a65dd0e9416ca303197a6e755982,

title = "The activation of the CGRP receptor",

abstract = "The CGRP (calcitonin gene-related peptide) receptor is a family B GPCR (G-protein-coupled receptor). It consists of a GPCR, CLR (calcitonin receptor-like receptor) and an accessory protein, RAMP1 (receptor activity modifying protein 1). RAMP1 is needed for CGRP binding and also cell-surface expression of CLR. CLR is an example of a family B GPCR. Unlike family A GPCRs, little is known about how these receptors are activated by their endogenous ligands. This review considers what is known about the activation of family B GPCRs and then considers how this might be applied to CLR, particularly in light of new knowledge of the crystal structures of family A GPCRs.",

keywords = "Alanine scan, Family A GPCRs, Family B GPCRs, Mutagenesis, Secretin-like GPCR, Structure-activity relationship",

author = "James Barwell and Mark Wheatley and Conner, {Alex C.} and Bruck Taddese and Shabana Vohra and Reynolds, {Christopher A.} and Poyner, {David R.}",

year = "2013",

month = feb,

day = "1",

doi = "10.1042/BST20120251",

language = "English",

volume = "41",

pages = "180--184",

journal = "Biochemical Society Transactions",

issn = "0300-5127",

publisher = "Portland Press",

number = "1",

}

TY - JOUR

T1 - The activation of the CGRP receptor

AU - Barwell, James

AU - Wheatley, Mark

AU - Conner, Alex C.

AU - Taddese, Bruck

AU - Vohra, Shabana

AU - Reynolds, Christopher A.

AU - Poyner, David R.

PY - 2013/2/1

Y1 - 2013/2/1

N2 - The CGRP (calcitonin gene-related peptide) receptor is a family B GPCR (G-protein-coupled receptor). It consists of a GPCR, CLR (calcitonin receptor-like receptor) and an accessory protein, RAMP1 (receptor activity modifying protein 1). RAMP1 is needed for CGRP binding and also cell-surface expression of CLR. CLR is an example of a family B GPCR. Unlike family A GPCRs, little is known about how these receptors are activated by their endogenous ligands. This review considers what is known about the activation of family B GPCRs and then considers how this might be applied to CLR, particularly in light of new knowledge of the crystal structures of family A GPCRs.

AB - The CGRP (calcitonin gene-related peptide) receptor is a family B GPCR (G-protein-coupled receptor). It consists of a GPCR, CLR (calcitonin receptor-like receptor) and an accessory protein, RAMP1 (receptor activity modifying protein 1). RAMP1 is needed for CGRP binding and also cell-surface expression of CLR. CLR is an example of a family B GPCR. Unlike family A GPCRs, little is known about how these receptors are activated by their endogenous ligands. This review considers what is known about the activation of family B GPCRs and then considers how this might be applied to CLR, particularly in light of new knowledge of the crystal structures of family A GPCRs.

KW - Alanine scan

KW - Family A GPCRs

KW - Family B GPCRs

KW - Mutagenesis

KW - Secretin-like GPCR

KW - Structure-activity relationship

UR - http://www.scopus.com/inward/record.url?scp=84873158298&partnerID=8YFLogxK

U2 - 10.1042/BST20120251

DO - 10.1042/BST20120251

M3 - Article

C2 - 23356280

AN - SCOPUS:84873158298

SN - 0300-5127

VL - 41

SP - 180

EP - 184

JO - Biochemical Society Transactions

JF - Biochemical Society Transactions

IS - 1

ER -

The activation of the CGRP receptor

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this