T-cell development in the fetus and the invariant series hypothesis

Richard Aspinall, Jaap Kampinga, Johan van den Bogaerde

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)


Comparison of the timing of appearance of certain T-cell markers in the intrathymic development o f T cells during gestation reveals a common sequence of expression in several species. Here Richard Aspinall and colleagues put forward a hypothesis concerning this 'invariant series' o f markers that shares the same timing o f expression across species barriers. It is proposed that T-cell markers that are members o f the invariant series are very important in deciding the fate of a developing thymocyte.

Original languageEnglish
Pages (from-to)7-10
Number of pages4
JournalImmunology Today
Issue number1
Publication statusPublished - Jan 1991
Externally publishedYes

ASJC Scopus subject areas

  • Immunology


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