T-cell development in the fetus and the invariant series hypothesis

Richard Aspinall, Jaap Kampinga, Johan van den Bogaerde

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Comparison of the timing of appearance of certain T-cell markers in the intrathymic development o f T cells during gestation reveals a common sequence of expression in several species. Here Richard Aspinall and colleagues put forward a hypothesis concerning this 'invariant series' o f markers that shares the same timing o f expression across species barriers. It is proposed that T-cell markers that are members o f the invariant series are very important in deciding the fate of a developing thymocyte.

Original languageEnglish
Pages (from-to)7-10
Number of pages4
JournalImmunology Today
Volume12
Issue number1
DOIs
Publication statusPublished - Jan 1991
Externally publishedYes

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Fetus
T-Lymphocytes
Thymocytes
Pregnancy

ASJC Scopus subject areas

  • Immunology

Cite this

T-cell development in the fetus and the invariant series hypothesis. / Aspinall, Richard; Kampinga, Jaap; van den Bogaerde, Johan.

In: Immunology Today, Vol. 12, No. 1, 01.1991, p. 7-10.

Research output: Contribution to journalArticle

Aspinall, Richard ; Kampinga, Jaap ; van den Bogaerde, Johan. / T-cell development in the fetus and the invariant series hypothesis. In: Immunology Today. 1991 ; Vol. 12, No. 1. pp. 7-10.
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