Synthesis of druglike molecules for respiratory diseases: Utilizing microwave chemistry

Valerie Boissel, Rebecca Butler, Paul J. Oakley, Neil J. Press

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Microwave-assisted organic synthesis, now ever-present in drug-discovery programs, is often reported with enhanced yields and reduced reaction times when compared with conventional heating. This is frequently coupled with a cleaner reaction profile and therefore more facile purification. At Novartis Institutes for Biomedical Research, in Horsham, UK, we research into new treatments for respiratory diseases and microwave-assisted chemistry is performed routinely within our laboratories. We have found that this form of heating significantly improves some reaction types, in particular, palladium-catalyzed processes such as Suzuki reactions. There is considerable literature in the use of microwaves to accelerate these types of palladium-catalyzed reactions. The following sections describe microwave reactions to prepare compounds that may be used to treat respiratory diseases which we, at Horsham, have found particularly interesting and offer genuine advantages over traditional thermal heating.
Original languageEnglish
Title of host publicationMicrowaves in Drug Discovery and Development: Recent Advances
EditorsJohn Spence, Mark Bagley
PublisherFuture Medicine Ltd.
Number of pages28
ISBN (Print)9781910419298
Publication statusPublished - 30 Oct 2014
Externally publishedYes


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