Synthesis and evaluation of the antimalarial, anticancer, and caspase 3 activities of tetraoxane dimers

R.K. Amewu; J. Chadwick; Afthab Hussain; S. Panda; R. Rinki; O. Janneh; S.A. Ward; C. Miguel; H. Burrell-Saward; L. Vivas; P.M. O’Neill

doi:10.1016/j.bmc.2013.09.047

Synthesis and evaluation of the antimalarial, anticancer, and caspase 3 activities of tetraoxane dimers

R.K. Amewu
, J. Chadwick
, Afthab Hussain
, S. Panda
, R. Rinki
, O. Janneh
, S.A. Ward
, C. Miguel
, H. Burrell-Saward
, L. Vivas
, P.M. O’Neill

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

The synthesis of a range of mono spiro and dispiro 1,2,4,5-tetraoxane dimers is described. Selected molecules were examined in in vitro assays to determine their antimalarial and anticancer potential. Our studies reveal that several molecules possess potent nanomolar antimalarial and single digit micromolar antiproliferative IC50s versus colon (HT29-AK and leukemia (HL60) cell lines. A graphical abstract is available from http://dx.doi.org/10.1016/j.bmc.2013.09.047.

Original language	English
Pages (from-to)	7392–7397
Journal	Bioorganic and Medicinal Chemistry
Volume	21
Issue number	23
DOIs	https://doi.org/10.1016/j.bmc.2013.09.047
Publication status	Published - 2013

Bibliographical note

The full text of this item is not available from the repository.

Funder

EU (Antimal. FP6 Malaria Drugs Initiative)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

malaria
leukaemia
apoptosis

Access to Document

10.1016/j.bmc.2013.09.047

Cite this

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title = "Synthesis and evaluation of the antimalarial, anticancer, and caspase 3 activities of tetraoxane dimers",

abstract = "The synthesis of a range of mono spiro and dispiro 1,2,4,5-tetraoxane dimers is described. Selected molecules were examined in in vitro assays to determine their antimalarial and anticancer potential. Our studies reveal that several molecules possess potent nanomolar antimalarial and single digit micromolar antiproliferative IC50s versus colon (HT29-AK and leukemia (HL60) cell lines. A graphical abstract is available from http://dx.doi.org/10.1016/j.bmc.2013.09.047.",

keywords = "malaria, leukaemia, apoptosis",

author = "R.K. Amewu and J. Chadwick and Afthab Hussain and S. Panda and R. Rinki and O. Janneh and S.A. Ward and C. Miguel and H. Burrell-Saward and L. Vivas and P.M. O{\textquoteright}Neill",

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year = "2013",

doi = "10.1016/j.bmc.2013.09.047",

language = "English",

volume = "21",

pages = "7392–7397",

journal = "Bioorganic and Medicinal Chemistry",

issn = "1464-3391",

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number = "23",

}

TY - JOUR

T1 - Synthesis and evaluation of the antimalarial, anticancer, and caspase 3 activities of tetraoxane dimers

AU - Amewu, R.K.

AU - Chadwick, J.

AU - Hussain, Afthab

AU - Panda, S.

AU - Rinki, R.

AU - Janneh, O.

AU - Ward, S.A.

AU - Miguel, C.

AU - Burrell-Saward, H.

AU - Vivas, L.

AU - O’Neill, P.M.

N1 - The full text of this item is not available from the repository.

PY - 2013

Y1 - 2013

N2 - The synthesis of a range of mono spiro and dispiro 1,2,4,5-tetraoxane dimers is described. Selected molecules were examined in in vitro assays to determine their antimalarial and anticancer potential. Our studies reveal that several molecules possess potent nanomolar antimalarial and single digit micromolar antiproliferative IC50s versus colon (HT29-AK and leukemia (HL60) cell lines. A graphical abstract is available from http://dx.doi.org/10.1016/j.bmc.2013.09.047.

AB - The synthesis of a range of mono spiro and dispiro 1,2,4,5-tetraoxane dimers is described. Selected molecules were examined in in vitro assays to determine their antimalarial and anticancer potential. Our studies reveal that several molecules possess potent nanomolar antimalarial and single digit micromolar antiproliferative IC50s versus colon (HT29-AK and leukemia (HL60) cell lines. A graphical abstract is available from http://dx.doi.org/10.1016/j.bmc.2013.09.047.

KW - malaria

KW - leukaemia

KW - apoptosis

U2 - 10.1016/j.bmc.2013.09.047

DO - 10.1016/j.bmc.2013.09.047

M3 - Article

SN - 1464-3391

VL - 21

SP - 7392

EP - 7397

JO - Bioorganic and Medicinal Chemistry

JF - Bioorganic and Medicinal Chemistry

IS - 23

ER -

Synthesis and evaluation of the antimalarial, anticancer, and caspase 3 activities of tetraoxane dimers

Abstract

Bibliographical note

Funder

UN SDGs

Keywords

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