Synthesis and evaluation of the antimalarial, anticancer, and caspase 3 activities of tetraoxane dimers

R.K. Amewu, J. Chadwick, Afthab Hussain, S. Panda, R. Rinki, O. Janneh, S.A. Ward, C. Miguel, H. Burrell-Saward, L. Vivas, P.M. O’Neill

    Research output: Contribution to journalArticle

    9 Citations (Scopus)

    Abstract

    The synthesis of a range of mono spiro and dispiro 1,2,4,5-tetraoxane dimers is described. Selected molecules were examined in in vitro assays to determine their antimalarial and anticancer potential. Our studies reveal that several molecules possess potent nanomolar antimalarial and single digit micromolar antiproliferative IC50s versus colon (HT29-AK and leukemia (HL60) cell lines. A graphical abstract is available from http://dx.doi.org/10.1016/j.bmc.2013.09.047.
    Original languageEnglish
    Pages (from-to)7392–7397
    JournalBioorganic and Medicinal Chemistry
    Volume21
    Issue number23
    DOIs
    Publication statusPublished - 2013

    Fingerprint

    Tetraoxanes
    Antimalarials
    Caspase 3
    Dimers
    Molecules
    HL-60 Cells
    Assays
    Colon
    Leukemia
    Cells
    Cell Line

    Bibliographical note

    The full text of this item is not available from the repository.

    Keywords

    • malaria
    • leukaemia
    • apoptosis

    Cite this

    Amewu, R. K., Chadwick, J., Hussain, A., Panda, S., Rinki, R., Janneh, O., ... O’Neill, P. M. (2013). Synthesis and evaluation of the antimalarial, anticancer, and caspase 3 activities of tetraoxane dimers. Bioorganic and Medicinal Chemistry, 21(23), 7392–7397. https://doi.org/10.1016/j.bmc.2013.09.047

    Synthesis and evaluation of the antimalarial, anticancer, and caspase 3 activities of tetraoxane dimers. / Amewu, R.K.; Chadwick, J.; Hussain, Afthab; Panda, S.; Rinki, R.; Janneh, O.; Ward, S.A.; Miguel, C.; Burrell-Saward, H.; Vivas, L.; O’Neill, P.M.

    In: Bioorganic and Medicinal Chemistry, Vol. 21, No. 23, 2013, p. 7392–7397.

    Research output: Contribution to journalArticle

    Amewu, RK, Chadwick, J, Hussain, A, Panda, S, Rinki, R, Janneh, O, Ward, SA, Miguel, C, Burrell-Saward, H, Vivas, L & O’Neill, PM 2013, 'Synthesis and evaluation of the antimalarial, anticancer, and caspase 3 activities of tetraoxane dimers' Bioorganic and Medicinal Chemistry, vol. 21, no. 23, pp. 7392–7397. https://doi.org/10.1016/j.bmc.2013.09.047
    Amewu, R.K. ; Chadwick, J. ; Hussain, Afthab ; Panda, S. ; Rinki, R. ; Janneh, O. ; Ward, S.A. ; Miguel, C. ; Burrell-Saward, H. ; Vivas, L. ; O’Neill, P.M. / Synthesis and evaluation of the antimalarial, anticancer, and caspase 3 activities of tetraoxane dimers. In: Bioorganic and Medicinal Chemistry. 2013 ; Vol. 21, No. 23. pp. 7392–7397.
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    AU - Rinki, R.

    AU - Janneh, O.

    AU - Ward, S.A.

    AU - Miguel, C.

    AU - Burrell-Saward, H.

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