Synthesis and evaluation of the antimalarial, anticancer, and caspase 3 activities of tetraoxane dimers

R.K. Amewu, J. Chadwick, Afthab Hussain, S. Panda, R. Rinki, O. Janneh, S.A. Ward, C. Miguel, H. Burrell-Saward, L. Vivas, P.M. O’Neill

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    10 Citations (Scopus)

    Abstract

    The synthesis of a range of mono spiro and dispiro 1,2,4,5-tetraoxane dimers is described. Selected molecules were examined in in vitro assays to determine their antimalarial and anticancer potential. Our studies reveal that several molecules possess potent nanomolar antimalarial and single digit micromolar antiproliferative IC50s versus colon (HT29-AK and leukemia (HL60) cell lines. A graphical abstract is available from http://dx.doi.org/10.1016/j.bmc.2013.09.047.
    Original languageEnglish
    Pages (from-to)7392–7397
    JournalBioorganic and Medicinal Chemistry
    Volume21
    Issue number23
    DOIs
    Publication statusPublished - 2013

    Bibliographical note

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    Keywords

    • malaria
    • leukaemia
    • apoptosis

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    Amewu, R. K., Chadwick, J., Hussain, A., Panda, S., Rinki, R., Janneh, O., ... O’Neill, P. M. (2013). Synthesis and evaluation of the antimalarial, anticancer, and caspase 3 activities of tetraoxane dimers. Bioorganic and Medicinal Chemistry, 21(23), 7392–7397. https://doi.org/10.1016/j.bmc.2013.09.047