Sweet-beverage consumption and risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Eva M. Navarrete-Muñoz, Petra A. Wark, Dora Romaguera, Nirmala Bhoo-Pathy, Dominique Michaud, Esther Molina-Montes, Anne Tjønneland, Anja Olsen, Kim Overvad, Marie Christine Boutron-Ruault, Françoise Clavel-Chapelon, Guy Fagherazzi, Verena A. Katzke, Tilman Kühn, Annika Steffen, Antonia Trichopoulou, Eleni Klinaki, Eleni Maria Papatesta, Giovanna Masala, Vittorio Krogh & 21 others Rosario Tumino, Alessio Naccarati, Amalia Mattiello, Petra H. Peeters, Charlotta Rylander, Christine L. Parr, Guri Skeie, Elisabete Weiderpass, J. Ramón Quirós, Eric J. Duell, Miren Dorronsoro, José María Huerta, Eva Ardanaz, Nick Wareham, Kay Tee Khaw, Ruth C. Travis, Tim Key, Magdalena Stepien, Heinz Freisling, Elio Riboli, H. Bas Bueno-De-mesquita

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background: The consumption of sweet beverages has been associated with greater risk of type 2 diabetes and obesity, which may be involved in the development of pancreatic cancer. Therefore, it has been hypothesized that sweet beverages may increase pancreatic cancer risk as well.

Objective: We examined the association between sweet-beverage consumption (including total, sugar-sweetened, and artificially sweetened soft drink and juice and nectar consumption) and pancreatic cancer risk.

Design: The study was conducted within the European Prospective Investigation into Cancer and Nutrition cohort. A total of 477,199 participants (70.2% women) with a mean age of 51 y at baseline were included, and 865 exocrine pancreatic cancers were diagnosed after a median follow-up of 11.60 y (IQR: 10.10-12.60 y). Sweet-beverage consumption was assessed with the use of validated dietary questionnaires at baseline. HRs and 95% CIs were obtained with the use of multivariable Cox regression models that were stratified by age, sex, and center and adjusted for educational level, physical activity, smoking status, and alcohol consumption. Associations with total soft-drink consumption were adjusted for juice and nectar consumption and vice versa.

Results: Total soft-drink consumption (HR per 100 g/d: 1.03; 95% CI: 0.99, 1.07), sugar-sweetened soft-drink consumption (HR per 100 g/d: 1.02; 95% CI: 0.97, 1.08), and artificially sweetened soft-drink consumption (HR per 100 g/d: 1.04; 95% CI: 0.98, 1.10) were not associated with pancreatic cancer risk. Juice and nectar consumption was inversely associated with pancreatic cancer risk (HR per 100 g/d: 0.91; 95% CI: 0.84, 0.99); this association remained statistically significant after adjustment for body size, type 2 diabetes, and energy intake.

Conclusions: Soft-drink consumption does not seem to be associated with pancreatic cancer risk. Juice and nectar consumption might be associated with a modest decreased pancreatic cancer risk. Additional studies with specific information on juice and nectar subtypes are warranted to clarify these results.

Original languageEnglish
Pages (from-to)760-768
Number of pages9
JournalAmerican Journal of Clinical Nutrition
Volume104
Issue number3
DOIs
Publication statusPublished - 1 Sep 2016
Externally publishedYes

Fingerprint

Beverages
Pancreatic Neoplasms
Carbonated Beverages
Plant Nectar
Neoplasms
Type 2 Diabetes Mellitus
Somatotypes
Body Size
Energy Intake
Proportional Hazards Models
Alcohol Drinking
Obesity
Smoking
Exercise

Keywords

  • Epidemiology
  • Juice and nectar
  • Pancreatic cancer
  • Prevention
  • Risk factors
  • Soft drinks
  • Sugary drinks
  • Sweet beverages

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Sweet-beverage consumption and risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC). / Navarrete-Muñoz, Eva M.; Wark, Petra A.; Romaguera, Dora; Bhoo-Pathy, Nirmala; Michaud, Dominique; Molina-Montes, Esther; Tjønneland, Anne; Olsen, Anja; Overvad, Kim; Boutron-Ruault, Marie Christine; Clavel-Chapelon, Françoise; Fagherazzi, Guy; Katzke, Verena A.; Kühn, Tilman; Steffen, Annika; Trichopoulou, Antonia; Klinaki, Eleni; Papatesta, Eleni Maria; Masala, Giovanna; Krogh, Vittorio; Tumino, Rosario; Naccarati, Alessio; Mattiello, Amalia; Peeters, Petra H.; Rylander, Charlotta; Parr, Christine L.; Skeie, Guri; Weiderpass, Elisabete; Quirós, J. Ramón; Duell, Eric J.; Dorronsoro, Miren; Huerta, José María; Ardanaz, Eva; Wareham, Nick; Khaw, Kay Tee; Travis, Ruth C.; Key, Tim; Stepien, Magdalena; Freisling, Heinz; Riboli, Elio; Bueno-De-mesquita, H. Bas.

In: American Journal of Clinical Nutrition, Vol. 104, No. 3, 01.09.2016, p. 760-768.

Research output: Contribution to journalArticle

Navarrete-Muñoz, EM, Wark, PA, Romaguera, D, Bhoo-Pathy, N, Michaud, D, Molina-Montes, E, Tjønneland, A, Olsen, A, Overvad, K, Boutron-Ruault, MC, Clavel-Chapelon, F, Fagherazzi, G, Katzke, VA, Kühn, T, Steffen, A, Trichopoulou, A, Klinaki, E, Papatesta, EM, Masala, G, Krogh, V, Tumino, R, Naccarati, A, Mattiello, A, Peeters, PH, Rylander, C, Parr, CL, Skeie, G, Weiderpass, E, Quirós, JR, Duell, EJ, Dorronsoro, M, Huerta, JM, Ardanaz, E, Wareham, N, Khaw, KT, Travis, RC, Key, T, Stepien, M, Freisling, H, Riboli, E & Bueno-De-mesquita, HB 2016, 'Sweet-beverage consumption and risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)' American Journal of Clinical Nutrition, vol. 104, no. 3, pp. 760-768. https://doi.org/10.3945/ajcn.116.130963
Navarrete-Muñoz, Eva M. ; Wark, Petra A. ; Romaguera, Dora ; Bhoo-Pathy, Nirmala ; Michaud, Dominique ; Molina-Montes, Esther ; Tjønneland, Anne ; Olsen, Anja ; Overvad, Kim ; Boutron-Ruault, Marie Christine ; Clavel-Chapelon, Françoise ; Fagherazzi, Guy ; Katzke, Verena A. ; Kühn, Tilman ; Steffen, Annika ; Trichopoulou, Antonia ; Klinaki, Eleni ; Papatesta, Eleni Maria ; Masala, Giovanna ; Krogh, Vittorio ; Tumino, Rosario ; Naccarati, Alessio ; Mattiello, Amalia ; Peeters, Petra H. ; Rylander, Charlotta ; Parr, Christine L. ; Skeie, Guri ; Weiderpass, Elisabete ; Quirós, J. Ramón ; Duell, Eric J. ; Dorronsoro, Miren ; Huerta, José María ; Ardanaz, Eva ; Wareham, Nick ; Khaw, Kay Tee ; Travis, Ruth C. ; Key, Tim ; Stepien, Magdalena ; Freisling, Heinz ; Riboli, Elio ; Bueno-De-mesquita, H. Bas. / Sweet-beverage consumption and risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC). In: American Journal of Clinical Nutrition. 2016 ; Vol. 104, No. 3. pp. 760-768.
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abstract = "Background: The consumption of sweet beverages has been associated with greater risk of type 2 diabetes and obesity, which may be involved in the development of pancreatic cancer. Therefore, it has been hypothesized that sweet beverages may increase pancreatic cancer risk as well.Objective: We examined the association between sweet-beverage consumption (including total, sugar-sweetened, and artificially sweetened soft drink and juice and nectar consumption) and pancreatic cancer risk.Design: The study was conducted within the European Prospective Investigation into Cancer and Nutrition cohort. A total of 477,199 participants (70.2{\%} women) with a mean age of 51 y at baseline were included, and 865 exocrine pancreatic cancers were diagnosed after a median follow-up of 11.60 y (IQR: 10.10-12.60 y). Sweet-beverage consumption was assessed with the use of validated dietary questionnaires at baseline. HRs and 95{\%} CIs were obtained with the use of multivariable Cox regression models that were stratified by age, sex, and center and adjusted for educational level, physical activity, smoking status, and alcohol consumption. Associations with total soft-drink consumption were adjusted for juice and nectar consumption and vice versa.Results: Total soft-drink consumption (HR per 100 g/d: 1.03; 95{\%} CI: 0.99, 1.07), sugar-sweetened soft-drink consumption (HR per 100 g/d: 1.02; 95{\%} CI: 0.97, 1.08), and artificially sweetened soft-drink consumption (HR per 100 g/d: 1.04; 95{\%} CI: 0.98, 1.10) were not associated with pancreatic cancer risk. Juice and nectar consumption was inversely associated with pancreatic cancer risk (HR per 100 g/d: 0.91; 95{\%} CI: 0.84, 0.99); this association remained statistically significant after adjustment for body size, type 2 diabetes, and energy intake.Conclusions: Soft-drink consumption does not seem to be associated with pancreatic cancer risk. Juice and nectar consumption might be associated with a modest decreased pancreatic cancer risk. Additional studies with specific information on juice and nectar subtypes are warranted to clarify these results.",
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TY - JOUR

T1 - Sweet-beverage consumption and risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)

AU - Navarrete-Muñoz, Eva M.

AU - Wark, Petra A.

AU - Romaguera, Dora

AU - Bhoo-Pathy, Nirmala

AU - Michaud, Dominique

AU - Molina-Montes, Esther

AU - Tjønneland, Anne

AU - Olsen, Anja

AU - Overvad, Kim

AU - Boutron-Ruault, Marie Christine

AU - Clavel-Chapelon, Françoise

AU - Fagherazzi, Guy

AU - Katzke, Verena A.

AU - Kühn, Tilman

AU - Steffen, Annika

AU - Trichopoulou, Antonia

AU - Klinaki, Eleni

AU - Papatesta, Eleni Maria

AU - Masala, Giovanna

AU - Krogh, Vittorio

AU - Tumino, Rosario

AU - Naccarati, Alessio

AU - Mattiello, Amalia

AU - Peeters, Petra H.

AU - Rylander, Charlotta

AU - Parr, Christine L.

AU - Skeie, Guri

AU - Weiderpass, Elisabete

AU - Quirós, J. Ramón

AU - Duell, Eric J.

AU - Dorronsoro, Miren

AU - Huerta, José María

AU - Ardanaz, Eva

AU - Wareham, Nick

AU - Khaw, Kay Tee

AU - Travis, Ruth C.

AU - Key, Tim

AU - Stepien, Magdalena

AU - Freisling, Heinz

AU - Riboli, Elio

AU - Bueno-De-mesquita, H. Bas

PY - 2016/9/1

Y1 - 2016/9/1

N2 - Background: The consumption of sweet beverages has been associated with greater risk of type 2 diabetes and obesity, which may be involved in the development of pancreatic cancer. Therefore, it has been hypothesized that sweet beverages may increase pancreatic cancer risk as well.Objective: We examined the association between sweet-beverage consumption (including total, sugar-sweetened, and artificially sweetened soft drink and juice and nectar consumption) and pancreatic cancer risk.Design: The study was conducted within the European Prospective Investigation into Cancer and Nutrition cohort. A total of 477,199 participants (70.2% women) with a mean age of 51 y at baseline were included, and 865 exocrine pancreatic cancers were diagnosed after a median follow-up of 11.60 y (IQR: 10.10-12.60 y). Sweet-beverage consumption was assessed with the use of validated dietary questionnaires at baseline. HRs and 95% CIs were obtained with the use of multivariable Cox regression models that were stratified by age, sex, and center and adjusted for educational level, physical activity, smoking status, and alcohol consumption. Associations with total soft-drink consumption were adjusted for juice and nectar consumption and vice versa.Results: Total soft-drink consumption (HR per 100 g/d: 1.03; 95% CI: 0.99, 1.07), sugar-sweetened soft-drink consumption (HR per 100 g/d: 1.02; 95% CI: 0.97, 1.08), and artificially sweetened soft-drink consumption (HR per 100 g/d: 1.04; 95% CI: 0.98, 1.10) were not associated with pancreatic cancer risk. Juice and nectar consumption was inversely associated with pancreatic cancer risk (HR per 100 g/d: 0.91; 95% CI: 0.84, 0.99); this association remained statistically significant after adjustment for body size, type 2 diabetes, and energy intake.Conclusions: Soft-drink consumption does not seem to be associated with pancreatic cancer risk. Juice and nectar consumption might be associated with a modest decreased pancreatic cancer risk. Additional studies with specific information on juice and nectar subtypes are warranted to clarify these results.

AB - Background: The consumption of sweet beverages has been associated with greater risk of type 2 diabetes and obesity, which may be involved in the development of pancreatic cancer. Therefore, it has been hypothesized that sweet beverages may increase pancreatic cancer risk as well.Objective: We examined the association between sweet-beverage consumption (including total, sugar-sweetened, and artificially sweetened soft drink and juice and nectar consumption) and pancreatic cancer risk.Design: The study was conducted within the European Prospective Investigation into Cancer and Nutrition cohort. A total of 477,199 participants (70.2% women) with a mean age of 51 y at baseline were included, and 865 exocrine pancreatic cancers were diagnosed after a median follow-up of 11.60 y (IQR: 10.10-12.60 y). Sweet-beverage consumption was assessed with the use of validated dietary questionnaires at baseline. HRs and 95% CIs were obtained with the use of multivariable Cox regression models that were stratified by age, sex, and center and adjusted for educational level, physical activity, smoking status, and alcohol consumption. Associations with total soft-drink consumption were adjusted for juice and nectar consumption and vice versa.Results: Total soft-drink consumption (HR per 100 g/d: 1.03; 95% CI: 0.99, 1.07), sugar-sweetened soft-drink consumption (HR per 100 g/d: 1.02; 95% CI: 0.97, 1.08), and artificially sweetened soft-drink consumption (HR per 100 g/d: 1.04; 95% CI: 0.98, 1.10) were not associated with pancreatic cancer risk. Juice and nectar consumption was inversely associated with pancreatic cancer risk (HR per 100 g/d: 0.91; 95% CI: 0.84, 0.99); this association remained statistically significant after adjustment for body size, type 2 diabetes, and energy intake.Conclusions: Soft-drink consumption does not seem to be associated with pancreatic cancer risk. Juice and nectar consumption might be associated with a modest decreased pancreatic cancer risk. Additional studies with specific information on juice and nectar subtypes are warranted to clarify these results.

KW - Epidemiology

KW - Juice and nectar

KW - Pancreatic cancer

KW - Prevention

KW - Risk factors

KW - Soft drinks

KW - Sugary drinks

KW - Sweet beverages

U2 - 10.3945/ajcn.116.130963

DO - 10.3945/ajcn.116.130963

M3 - Article

VL - 104

SP - 760

EP - 768

JO - The American Journal of Clinical Nutrition

JF - The American Journal of Clinical Nutrition

SN - 0002-9165

IS - 3

ER -