Sustainability of a Three-Species Predator–Prey Model in Tumor-Immune Dynamics with Periodic Treatment

Avan Al-Saffar; Eun-jin  Kim

doi:10.3390/e27030264

Sustainability of a Three-Species Predator–Prey Model in Tumor-Immune Dynamics with Periodic Treatment

Avan Al-Saffar
, Eun-jin Kim

Research Centre for Fluid and Complex Systems

University of Duhok

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

10 Downloads (Pure)

Abstract

Using a tumor-immune growth model, we investigate how immunotherapy affects its dynamical characteristics. Specifically, we extend the prey–predator model of tumor cells and immune cells by including periodic immunotherapy, the nonlinear damping of cancer cells, and the dynamics of a healthy cell population, and investigate the effects of the model parameters. The ideal value of immunotherapy, which promotes the growth of immune (and healthy) cells while contributing to the elimination or control of the cancer cells, is determined by using Fisher information as a measure of variability throughout our study.

Original language	English
Article number	264
Number of pages	14
Journal	Entropy
Volume	27
Issue number	3
DOIs	https://doi.org/10.3390/e27030264
Publication status	Published - 3 Mar 2025

Bibliographical note

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

dynamical systems
fisher information
perturbations
probability density function (PDF)
sustainability

ASJC Scopus subject areas

Information Systems
Mathematical Physics
Physics and Astronomy (miscellaneous)
General Physics and Astronomy
Electrical and Electronic Engineering

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10.3390/e27030264

Kim2025VORFinal published version, 739 KBLicence: CC BY

Cite this

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title = "Sustainability of a Three-Species Predator–Prey Model in Tumor-Immune Dynamics with Periodic Treatment",

abstract = "Using a tumor-immune growth model, we investigate how immunotherapy affects its dynamical characteristics. Specifically, we extend the prey–predator model of tumor cells and immune cells by including periodic immunotherapy, the nonlinear damping of cancer cells, and the dynamics of a healthy cell population, and investigate the effects of the model parameters. The ideal value of immunotherapy, which promotes the growth of immune (and healthy) cells while contributing to the elimination or control of the cancer cells, is determined by using Fisher information as a measure of variability throughout our study.",

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N2 - Using a tumor-immune growth model, we investigate how immunotherapy affects its dynamical characteristics. Specifically, we extend the prey–predator model of tumor cells and immune cells by including periodic immunotherapy, the nonlinear damping of cancer cells, and the dynamics of a healthy cell population, and investigate the effects of the model parameters. The ideal value of immunotherapy, which promotes the growth of immune (and healthy) cells while contributing to the elimination or control of the cancer cells, is determined by using Fisher information as a measure of variability throughout our study.

AB - Using a tumor-immune growth model, we investigate how immunotherapy affects its dynamical characteristics. Specifically, we extend the prey–predator model of tumor cells and immune cells by including periodic immunotherapy, the nonlinear damping of cancer cells, and the dynamics of a healthy cell population, and investigate the effects of the model parameters. The ideal value of immunotherapy, which promotes the growth of immune (and healthy) cells while contributing to the elimination or control of the cancer cells, is determined by using Fisher information as a measure of variability throughout our study.

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KW - fisher information

KW - perturbations

KW - probability density function (PDF)

KW - sustainability

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Sustainability of a Three-Species Predator–Prey Model in Tumor-Immune Dynamics with Periodic Treatment

Abstract

Bibliographical note

UN SDGs

Keywords

ASJC Scopus subject areas

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