Abstract
Purpose: To investigate the effects of a supported home-based progressive resistance exercise training (RET) programme on indices of cardiovascular health, muscular strength and health-related quality of life (HR-QoL) in prostate cancer (PCa) patients after treatment with robot-assisted radical prostatectomy (RARP). Methods: This study was a single-site, two-arm randomised controlled trial, with 40 participants randomised to either the intervention or control group over a 10-month period. In addition to receiving usual care, the intervention group completed three weekly RET sessions using resistance bands for 6 months. Participants performed 3 sets of 12–15 repetitions for each exercise, targeting each major muscle group. The control group received usual care only. Brachial artery flow-mediated dilatation (FMD) was the primary outcome and assessed at baseline, 3 and 6 months. Secondary outcomes included body weight, body fat, aerobic fitness, strength and blood-borne biomarkers associated with cardiometabolic risk. Results: There was no significant difference between the groups in FMD at 3 or 6 months. However, there were improvements in aerobic exercise capacity (P < 0.01) and upper- (P < 0.01) and lower-limb (P = 0.01) strength in favour of the RET group at 6 months, accompanied by greater weight loss (P = 0.04) and a reduction in body fat (P = 0.02). Improvements in HRQoL were evident in the RET group at 3 and 6 months via the PCa-specific component of the FACT-P questionnaire (both P < 0.01). Five adverse events and one serious adverse event were reported throughout the trial duration. Conclusion: This study demonstrates that home-based RET is an effective and safe mode of exercise that elicits beneficial effects on aerobic exercise capacity, muscular strength and HR-QoL in men who have undergone RARP. Trial registration: ISRCTN10490647.
| Original language | English |
|---|---|
| Pages (from-to) | 4595-4605 |
| Number of pages | 11 |
| Journal | Supportive Care in Cancer |
| Volume | 29 |
| Issue number | 8 |
| Early online date | 23 Jan 2021 |
| DOIs | |
| Publication status | E-pub ahead of print - 23 Jan 2021 |
| Externally published | Yes |
Bibliographical note
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.Funder
This study was funded by The Urology Foundation.Acknowledgement should be given to the Newcastle Upon Tyne Patient and Public Involvement Group for their support and valuable feedback.
Funding
This study was funded by The Urology Foundation. Acknowledgement should be given to the Newcastle Upon Tyne Patient and Public Involvement Group for their support and valuable feedback.
| Funders | Funder number |
|---|---|
| Patient & Public Involvement | |
| Urology Foundation |
Keywords
- Cardiometabolic
- Prostate cancer
- Resistance exercise
- Robot-assisted radical prostatectomy
ASJC Scopus subject areas
- Oncology
