Sugary interfaces mitigate contact damage where stiff meets soft

Hee Young Yoo, Mihaela Iordachescu, Jun Huang, Elise Hennebert, Sangsik Kim, Sangchul Rho, Mathias Foo, Patrick Flammang, Hongbo Zeng, Daehee Hwang, J. Herbert Waite, Dong Soo Hwang

Research output: Contribution to journalArticle

13 Citations (Scopus)
12 Downloads (Pure)

Abstract

The byssal threads of the fan shell Atrina pectinata are non-living functional materials intimately associated with living tissue, which provide an intriguing paradigm of bionic interface for robust load-bearing device. An interfacial load-bearing protein (A. pectinata foot protein-1, apfp-1) with L-3,4-dihydroxyphenylalanine (DOPA)-containing and mannose-binding domains has been characterized from Atrina's foot. apfp-1 was localized at the interface between stiff byssus and the soft tissue by immunochemical staining and confocal Raman imaging, implying that apfp-1 is an interfacial linker between the byssus and soft tissue, that is, the DOPA-containing domain interacts with itself and other byssal proteins via Fe3 + -DOPA complexes, and the mannose-binding domain interacts with the soft tissue and cell membranes. Both DOPA- and sugar-mediated bindings are reversible and robust under wet conditions. This work shows the combination of DOPA and sugar chemistry at asymmetric interfaces is unprecedented and highly relevant to bionic interface design for tissue engineering and bionic devices.

Publisher Statement: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise
in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit
http://creativecommons.org/licenses/by/4.0/
Original languageEnglish
Article number11923
Number of pages8
JournalNature Communications
Volume7
DOIs
Publication statusPublished - 16 Jun 2016

Fingerprint

dopa
Dihydroxyphenylalanine
Licensure
Bionics
Bearings (structural)
bionics
Tissue
damage
proteins
Foot
Mannose
Sugars
sugars
Proteins
Weight-Bearing
Functional materials
Staphylococcal Protein A
Levodopa
Cell membranes
Tissue engineering

Bibliographical note

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material.
To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

Cite this

Yoo, H. Y., Iordachescu, M., Huang, J., Hennebert, E., Kim, S., Rho, S., ... Hwang, D. S. (2016). Sugary interfaces mitigate contact damage where stiff meets soft. Nature Communications, 7, [11923 ]. https://doi.org/10.1038/ncomms11923

Sugary interfaces mitigate contact damage where stiff meets soft. / Yoo, Hee Young; Iordachescu, Mihaela; Huang, Jun; Hennebert, Elise; Kim, Sangsik; Rho, Sangchul; Foo, Mathias; Flammang, Patrick; Zeng, Hongbo; Hwang, Daehee; Waite, J. Herbert; Hwang, Dong Soo.

In: Nature Communications, Vol. 7, 11923 , 16.06.2016.

Research output: Contribution to journalArticle

Yoo, HY, Iordachescu, M, Huang, J, Hennebert, E, Kim, S, Rho, S, Foo, M, Flammang, P, Zeng, H, Hwang, D, Waite, JH & Hwang, DS 2016, 'Sugary interfaces mitigate contact damage where stiff meets soft' Nature Communications, vol. 7, 11923 . https://doi.org/10.1038/ncomms11923
Yoo HY, Iordachescu M, Huang J, Hennebert E, Kim S, Rho S et al. Sugary interfaces mitigate contact damage where stiff meets soft. Nature Communications. 2016 Jun 16;7. 11923 . https://doi.org/10.1038/ncomms11923
Yoo, Hee Young ; Iordachescu, Mihaela ; Huang, Jun ; Hennebert, Elise ; Kim, Sangsik ; Rho, Sangchul ; Foo, Mathias ; Flammang, Patrick ; Zeng, Hongbo ; Hwang, Daehee ; Waite, J. Herbert ; Hwang, Dong Soo. / Sugary interfaces mitigate contact damage where stiff meets soft. In: Nature Communications. 2016 ; Vol. 7.
@article{cab2a5f332ae4366a1b55c5eff5de355,
title = "Sugary interfaces mitigate contact damage where stiff meets soft",
abstract = "The byssal threads of the fan shell Atrina pectinata are non-living functional materials intimately associated with living tissue, which provide an intriguing paradigm of bionic interface for robust load-bearing device. An interfacial load-bearing protein (A. pectinata foot protein-1, apfp-1) with L-3,4-dihydroxyphenylalanine (DOPA)-containing and mannose-binding domains has been characterized from Atrina's foot. apfp-1 was localized at the interface between stiff byssus and the soft tissue by immunochemical staining and confocal Raman imaging, implying that apfp-1 is an interfacial linker between the byssus and soft tissue, that is, the DOPA-containing domain interacts with itself and other byssal proteins via Fe3 + -DOPA complexes, and the mannose-binding domain interacts with the soft tissue and cell membranes. Both DOPA- and sugar-mediated bindings are reversible and robust under wet conditions. This work shows the combination of DOPA and sugar chemistry at asymmetric interfaces is unprecedented and highly relevant to bionic interface design for tissue engineering and bionic devices.Publisher Statement: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwisein the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/",
author = "Yoo, {Hee Young} and Mihaela Iordachescu and Jun Huang and Elise Hennebert and Sangsik Kim and Sangchul Rho and Mathias Foo and Patrick Flammang and Hongbo Zeng and Daehee Hwang and Waite, {J. Herbert} and Hwang, {Dong Soo}",
note = "This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/",
year = "2016",
month = "6",
day = "16",
doi = "10.1038/ncomms11923",
language = "English",
volume = "7",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",

}

TY - JOUR

T1 - Sugary interfaces mitigate contact damage where stiff meets soft

AU - Yoo, Hee Young

AU - Iordachescu, Mihaela

AU - Huang, Jun

AU - Hennebert, Elise

AU - Kim, Sangsik

AU - Rho, Sangchul

AU - Foo, Mathias

AU - Flammang, Patrick

AU - Zeng, Hongbo

AU - Hwang, Daehee

AU - Waite, J. Herbert

AU - Hwang, Dong Soo

N1 - This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

PY - 2016/6/16

Y1 - 2016/6/16

N2 - The byssal threads of the fan shell Atrina pectinata are non-living functional materials intimately associated with living tissue, which provide an intriguing paradigm of bionic interface for robust load-bearing device. An interfacial load-bearing protein (A. pectinata foot protein-1, apfp-1) with L-3,4-dihydroxyphenylalanine (DOPA)-containing and mannose-binding domains has been characterized from Atrina's foot. apfp-1 was localized at the interface between stiff byssus and the soft tissue by immunochemical staining and confocal Raman imaging, implying that apfp-1 is an interfacial linker between the byssus and soft tissue, that is, the DOPA-containing domain interacts with itself and other byssal proteins via Fe3 + -DOPA complexes, and the mannose-binding domain interacts with the soft tissue and cell membranes. Both DOPA- and sugar-mediated bindings are reversible and robust under wet conditions. This work shows the combination of DOPA and sugar chemistry at asymmetric interfaces is unprecedented and highly relevant to bionic interface design for tissue engineering and bionic devices.Publisher Statement: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwisein the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

AB - The byssal threads of the fan shell Atrina pectinata are non-living functional materials intimately associated with living tissue, which provide an intriguing paradigm of bionic interface for robust load-bearing device. An interfacial load-bearing protein (A. pectinata foot protein-1, apfp-1) with L-3,4-dihydroxyphenylalanine (DOPA)-containing and mannose-binding domains has been characterized from Atrina's foot. apfp-1 was localized at the interface between stiff byssus and the soft tissue by immunochemical staining and confocal Raman imaging, implying that apfp-1 is an interfacial linker between the byssus and soft tissue, that is, the DOPA-containing domain interacts with itself and other byssal proteins via Fe3 + -DOPA complexes, and the mannose-binding domain interacts with the soft tissue and cell membranes. Both DOPA- and sugar-mediated bindings are reversible and robust under wet conditions. This work shows the combination of DOPA and sugar chemistry at asymmetric interfaces is unprecedented and highly relevant to bionic interface design for tissue engineering and bionic devices.Publisher Statement: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwisein the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

U2 - 10.1038/ncomms11923

DO - 10.1038/ncomms11923

M3 - Article

VL - 7

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

M1 - 11923

ER -