Study on Theileria lestoquardi antigens as potential vaccine candidates

Mehdi Namavari, Mohammad H. Hosseini, Atefeh Seghatoleslam, Mohsen Lotfi, Ali Shirazi, Olivier A.E. Sparagano

Research output: Chapter in Book/Report/Conference proceedingConference proceeding

2 Citations (Scopus)

Abstract

Theileria lestoquardi is the causative agent of malignant theileriosis of sheep and goats, causing morbidity and mortality in these animals worldwide. Western blot analysis based on T. lestoquardi schizont antigens was carried out using sera collected from Iranian sheep, which had been immunized with T. lestoquardi schizont-infected cells. The results of Western blot analysis demonstrated that schizont-immunized animals produced antibodies reacting with protein bands at 73, 42, 20, 14, and 12 kDa. Comparison of the results of the current Western blotting test with earlier studies of Theileria spp. revealed two immunogenic schizont proteins with molecular weights of 73 and 42 kDa shared between T. annulata and T. lestoquardi. Two other proteins with molecular weights of 14 and 12 kDa have not been previously found in other Theileria species. Our results suggest that the 73-kDa protein could be a potential vaccine candidate and that the 14- and 12-kDa proteins could be considered as diagnostic antigens.

Original languageEnglish
Title of host publicationAnimal Biodiversity and Emerging Diseases Prediction and Prevention
PublisherWiley
Pages205-207
Number of pages3
Volume1149
ISBN (Print)9781573317146
DOIs
Publication statusPublished - 15 Dec 2008
Externally publishedYes

Publication series

NameAnnals of the New York Academy of Sciences
Volume1149
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632

Keywords

  • Antigen
  • Schizont
  • Sheep
  • Theileria lestoquardi

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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  • Cite this

    Namavari, M., Hosseini, M. H., Seghatoleslam, A., Lotfi, M., Shirazi, A., & Sparagano, O. A. E. (2008). Study on Theileria lestoquardi antigens as potential vaccine candidates. In Animal Biodiversity and Emerging Diseases Prediction and Prevention (Vol. 1149, pp. 205-207). (Annals of the New York Academy of Sciences; Vol. 1149). Wiley. https://doi.org/10.1196/annals.1428.020