The neurohypophysial hormones oxytocin (OT) and vasopressin (AVP) mediate their physiological role through interaction with specific receptors. The cloning of OT receptors (OTRs) and AVP receptors (VPRs) from several species has revealed the existence of four receptor subtypes (OT, V1a, V1b and V2). Sequence analysis of these cloned receptors has confirmed that they belong to the G-protein-coupled receptor (GPCR) family, characterised by seven hydrophobic αÁ-helical transmembrane (TM) domains.
|Title of host publication||Vasopressin and Oxytocin |
|Number of pages||3|
|Publication status||Published - 1998|
|Name||Advances in Experimental Medicine and Biology|
- Biochemistry, Genetics and Molecular Biology(all)