Structure, function and regulation of versican: the most abundant type of proteoglycan in the extracellular matrix

Fattah Sotoodehnejadnematalahi, Bernard Burke

Research output: Contribution to journalReview article

12 Citations (Scopus)
9 Downloads (Pure)

Abstract

One of the main members of the large aggregating proteoglycans (PGs) family is versican which is able to bind to hyaluronate. Versican is a chondroitin sulfate proteoglycan and is a key ingredient of the extracellular matrix. Due to its widespread expression in the body, versican is involved in cell adhesion, proliferation and migration. Induced expression of versican is often observed in tissues such as breast, brain, ovary, gastrointestinal tract, prostate, and melanoma. In addition, versican has important role in development. For example, versican conducts the embryonic cell migration which is essential in the formation of the heart and outlining the path for neural crest cell migration. Several studies in the past decade up to now have shown that versican produced by mononuclear cells has an important role in wound healing and blood vessel formation and suggested that it promotes tumorigenesis and angiogenesis. In this mini-review, we summarise and discuss the role of versican in healthy and pathological tissues and suggest the possible function of transcription factors and signalling pathway in regulation of versican.

Original languageEnglish
Pages (from-to)740-50
Number of pages11
JournalActa Medica Iranica
Volume51
Issue number11
Publication statusPublished - 2013

Fingerprint

Versicans
Proteoglycans
Extracellular Matrix
Cell Movement
Chondroitin Sulfate Proteoglycans
Neural Crest
Cell Adhesion
Wound Healing
Blood Vessels
Gastrointestinal Tract
Prostate
Ovary
Melanoma
Carcinogenesis
Breast
Transcription Factors
Cell Proliferation

Bibliographical note

This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.

Keywords

  • Base Sequence
  • Carbohydrate Conformation
  • DNA
  • Extracellular Matrix/metabolism
  • Molecular Sequence Data
  • Protein Conformation
  • Versicans/chemistry

Cite this

Structure, function and regulation of versican : the most abundant type of proteoglycan in the extracellular matrix. / Sotoodehnejadnematalahi, Fattah; Burke, Bernard.

In: Acta Medica Iranica, Vol. 51, No. 11, 2013, p. 740-50.

Research output: Contribution to journalReview article

@article{1e746df7635d43bebd54da38cd7da633,
title = "Structure, function and regulation of versican: the most abundant type of proteoglycan in the extracellular matrix",
abstract = "One of the main members of the large aggregating proteoglycans (PGs) family is versican which is able to bind to hyaluronate. Versican is a chondroitin sulfate proteoglycan and is a key ingredient of the extracellular matrix. Due to its widespread expression in the body, versican is involved in cell adhesion, proliferation and migration. Induced expression of versican is often observed in tissues such as breast, brain, ovary, gastrointestinal tract, prostate, and melanoma. In addition, versican has important role in development. For example, versican conducts the embryonic cell migration which is essential in the formation of the heart and outlining the path for neural crest cell migration. Several studies in the past decade up to now have shown that versican produced by mononuclear cells has an important role in wound healing and blood vessel formation and suggested that it promotes tumorigenesis and angiogenesis. In this mini-review, we summarise and discuss the role of versican in healthy and pathological tissues and suggest the possible function of transcription factors and signalling pathway in regulation of versican.",
keywords = "Base Sequence, Carbohydrate Conformation, DNA, Extracellular Matrix/metabolism, Molecular Sequence Data, Protein Conformation, Versicans/chemistry",
author = "Fattah Sotoodehnejadnematalahi and Bernard Burke",
note = "This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.",
year = "2013",
language = "English",
volume = "51",
pages = "740--50",
journal = "Acta Medica Iranica",
issn = "0044-6025",
publisher = "Tehran University of Medical Sciences",
number = "11",

}

TY - JOUR

T1 - Structure, function and regulation of versican

T2 - the most abundant type of proteoglycan in the extracellular matrix

AU - Sotoodehnejadnematalahi, Fattah

AU - Burke, Bernard

N1 - This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.

PY - 2013

Y1 - 2013

N2 - One of the main members of the large aggregating proteoglycans (PGs) family is versican which is able to bind to hyaluronate. Versican is a chondroitin sulfate proteoglycan and is a key ingredient of the extracellular matrix. Due to its widespread expression in the body, versican is involved in cell adhesion, proliferation and migration. Induced expression of versican is often observed in tissues such as breast, brain, ovary, gastrointestinal tract, prostate, and melanoma. In addition, versican has important role in development. For example, versican conducts the embryonic cell migration which is essential in the formation of the heart and outlining the path for neural crest cell migration. Several studies in the past decade up to now have shown that versican produced by mononuclear cells has an important role in wound healing and blood vessel formation and suggested that it promotes tumorigenesis and angiogenesis. In this mini-review, we summarise and discuss the role of versican in healthy and pathological tissues and suggest the possible function of transcription factors and signalling pathway in regulation of versican.

AB - One of the main members of the large aggregating proteoglycans (PGs) family is versican which is able to bind to hyaluronate. Versican is a chondroitin sulfate proteoglycan and is a key ingredient of the extracellular matrix. Due to its widespread expression in the body, versican is involved in cell adhesion, proliferation and migration. Induced expression of versican is often observed in tissues such as breast, brain, ovary, gastrointestinal tract, prostate, and melanoma. In addition, versican has important role in development. For example, versican conducts the embryonic cell migration which is essential in the formation of the heart and outlining the path for neural crest cell migration. Several studies in the past decade up to now have shown that versican produced by mononuclear cells has an important role in wound healing and blood vessel formation and suggested that it promotes tumorigenesis and angiogenesis. In this mini-review, we summarise and discuss the role of versican in healthy and pathological tissues and suggest the possible function of transcription factors and signalling pathway in regulation of versican.

KW - Base Sequence

KW - Carbohydrate Conformation

KW - DNA

KW - Extracellular Matrix/metabolism

KW - Molecular Sequence Data

KW - Protein Conformation

KW - Versicans/chemistry

M3 - Review article

VL - 51

SP - 740

EP - 750

JO - Acta Medica Iranica

JF - Acta Medica Iranica

SN - 0044-6025

IS - 11

ER -