State-of-the-Art Computational Models of Circle of Willis With Physiological Applications: A Review

Haipeng Liu, Defeng Wang, Xinyi Leng, Dingchang Zheng, Fei Chen, Lawrence Ka Sing Wong, Lin Shi, Thomas Wai Hong Leung

    Research output: Contribution to journalReview articlepeer-review

    37 Citations (Scopus)
    156 Downloads (Pure)

    Abstract

    Background: Various computational models of the circle of Willis (CoW) have been developed to non-invasively estimate the blood flow and hemodynamic parameters in intracranial arteries for the assessment of clinical risks such as aneurysms, ischemia, and atherosclerotic plaque growth. This review aims to
    categorize the latest computational models of CoW and summarize the innovative techniques.
    Summary of Review: In traditional computational models of CoW, the computational complexity increased from zero-dimensional models to one-dimensional and three-dimensional models. The applications extend from
    estimating certain hemodynamic parameters to simulating local flow field. The innovative techniques include the combination of models with different dimensions, the extension of vascular structure including heart and
    veins, as well as the addition of distal fractality, cerebral autoregulation, and intracranial pressure. There are some nontraditional models based on fluid-solid-interaction, control theory, and in-vitro experiments. In all kinds of models, the in-vivo data and non-Newtonian rheological models of blood have been widely applied to improve the accuracy of hemodynamic simulation.
    Conclusion: Firstly, the selection of model depends on its application scenario. The balance between computational complexity and physiological accuracy deserves further investigation. Secondly, the improvement of CoW models relies on the large-scale validations and the combination of various innovative modeling techniques.
    Original languageEnglish
    Pages (from-to)156261 - 156273
    Number of pages13
    JournalIEEE Access
    Volume8
    DOIs
    Publication statusPublished - 7 Jul 2020

    Bibliographical note

    This work is licensed under a Creative Commons Attribution 4.0 License. For more information, see https://creativecommons.org/licenses/by/4.0/

    Funding

    FundersFunder number
    Basic Research Foundation of ShenzhenGJHZ20180928155002157
    National Natural Science Foundation of China61828104, N_CUHK421/16
    Ministry of Education
    Research Grants Council, University Grants Committee14204117, 14106019
    Ministry of Finance China
    National Development and Reform Commission

      Keywords

      • Brain modeling
      • computational modeling
      • circle of Willis (CoW)
      • Windkessel effect
      • pulse wave
      • computational fluid dynamics (CFD)
      • cerebral blood flow
      • intracranial arteries

      ASJC Scopus subject areas

      • General Engineering
      • General Materials Science
      • General Computer Science

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