Soy intake is associated with lowering blood pressure in adults: A systematic review and meta-analysis of randomized double-blind placebo-controlled trials

Zahra Mosallanezhad, Sara Ranjbar, Marzieh Mahmoodi, Razieh Hosseini, Cain C T Clark, Kristin Carson-Chahhoud, Zahra Norouzi, Ali Abbasian, Mohammad Jalali

Research output: Contribution to journalReview articlepeer-review

Abstract

BACKGROUND: Soy has several beneficial effects on cardiovascular disease (CVD); however, results of clinical trial studies are equivocal. Thus, the present study sought to discern the efficacy of soy intake on blood pressure.

METHODS: The search process was conducted in PubMed, Scopus, Web of Science, and Cochrane Library, to ascertain studies investigating the efficacy of soy intake on blood pressure in adults, published up to June 2020. A random-effects model was applied to pool mean difference and 95% confidence intervals (CIs). Meta-regression analysis was performed to discern potential sources of heterogeneity. Begg's and Egger's methods were conducted to assess publication bias.

RESULTS: Pooled effects from 17 studies revealed a significant improvement in systolic blood pressure (SBP) (-1.64; -3.25 to -0.04 mmHg; I2 = 50.5 %) and diastolic blood pressure (DBP) (-1.21; -2.29 to -0.12 mmHg, I2 = 50.7 %) following soy consumption, in comparison with controls. Subgroup analysis demonstrated a reduction in both SBP and DBP in younger participants with lower baseline blood pressure and intervention durations of <16 weeks.

CONCLUSION: Our results suggest that soy intake is associated with an ameliorating effect on blood pressure in adults.

Original languageEnglish
Article number102692
Pages (from-to)(In-Press)
Number of pages38
JournalComplementary Therapies in Medicine
Volume(In-Press)
Early online date24 Feb 2021
DOIs
Publication statusE-pub ahead of print - 24 Feb 2021

Keywords

  • soy
  • blood pressure
  • hypertension
  • review
  • meta-analysis

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