Soy intake and breast cancer risk: a prospective study of 300,000 Chinese women and a dose–response meta-analysis

Yuxia Wei; Jun Lv; Yu Guo; Zheng Bian; Meng Gao; Huaidong Du; Ling Yang; Yiping Chen; Xi Zhang; Tao Wang; Junshi Chen; Zhengming Chen; Canqing Yu; Dezheng Huo; Liming Li; China Kadoorie Biobank (CKB) collaborative group

doi:10.1007/s10654-019-00585-4

Soy intake and breast cancer risk: a prospective study of 300,000 Chinese women and a dose–response meta-analysis

Yuxia Wei, Jun Lv, Yu Guo, Zheng Bian, Meng Gao, Huaidong Du, Ling Yang, Yiping Chen, Xi Zhang, Tao Wang, Junshi Chen, Zhengming Chen, Canqing Yu, Dezheng Huo, Liming Li, China Kadoorie Biobank (CKB) collaborative group

Research output: Contribution to journal › Article › peer-review

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Abstract

Epidemiological evidence on the association of soy intake with breast cancer risk is still inconsistent due to different soy intake levels across previous studies and small number of breast cancer cases. We aimed to investigate this issue by analyzing data from the China Kadoorie Biobank (CKB) study and conducting a dose–response meta-analysis to integrate existing evidence. The CKB study included over 300,000 women aged 30–79 from 10 regions across China enrolled between 2004 and 2008, and followed-up for breast cancer events until 31 December 2016. Information on soy intake was collected from baseline, two resurveys and twelve 24-h dietary recalls. We also searched for relevant prospective cohort studies to do a dose–response meta-analysis. The mean (SD) soy intake was 9.4 (5.4) mg/day soy isoflavones among CKB women. During 10 years of follow-up, 2289 women developed breast cancers. The multivariable-adjusted relative risk was 1.00 (95% confidence interval [CI] 0.81–1.22) for the fourth (19.1 mg/day) versus the first (4.5 mg/day) soy isoflavone intake quartile. Meta-analysis of prospective studies found that each 10 mg/day increment in soy isoflavone intake was associated with a 3% (95% CI 1–5%) reduced risk of breast cancer. The CKB study demonstrated that moderate soy intake was not associated with breast cancer risk among Chinese women. Higher amount of soy intake might provide reasonable benefits for the prevention of breast cancer.

Original language	English
Pages (from-to)	567-578
Number of pages	12
Journal	European Journal of Epidemiology
Volume	35
Issue number	6
Early online date	21 Nov 2019
DOIs	https://doi.org/10.1007/s10654-019-00585-4
Publication status	Published - Jun 2020

Bibliographical note

This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativeco
mmons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate
credit to the original author(s) and the source, provide a link to the
Creative Commons license, and indicate if changes were made

Funder

This work was supported by Grants (81530088, 81390540, 81390544, 81390541) from National Natural Science Foundation of China; (2016YFC0900500, 2016YFC0900501, 2016YFC0900504, 2016YFC1303904) from the National Key Research and Development Program of China; a grant from the Kadoorie Charitable Foundation in Hong Kong; Grants from the UK Wellcome Trust (202922/Z/16/Z, 088158/Z/09/Z, 104085/Z/14/Z); Grants from Chinese Ministry of Science and Technology (2011BAI09B01); and Breast Cancer Research Foundation. The funders and sponsors of the study had no role in the study design and conduct, data collection, data analysis, data interpretation, writing of the report, or the decision to submit the manuscript for publication. The corresponding author had full access to all the data in the study and had final responsibility for the decision to submit for publication.

Funding

This work was supported by Grants (81530088, 81390540, 81390544, 81390541) from National Natural Science Foundation of China; (2016YFC0900500, 2016YFC0900501, 2016YFC0900504, 2016YFC1303904) from the National Key Research and Development Program of China; a grant from the Kadoorie Charitable Foundation in Hong Kong; Grants from the UK Wellcome Trust (202922/Z/16/Z, 088158/Z/09/Z, 104085/Z/14/Z); Grants from Chinese Ministry of Science and Technology (2011BAI09B01); and Breast Cancer Research Foundation. The funders and sponsors of the study had no role in the study design and conduct, data collection, data analysis, data interpretation, writing of the report, or the decision to submit the manuscript for publication. The corresponding author had full access to all the data in the study and had final responsibility for the decision to submit for publication.

Funders	Funder number
National Natural Science Foundation of China	81530088, 81390540, 81390544, 81390541
National Key Research and Development Program of China	2016YFC0900500, 2016YFC0900501, 2016YFC0900504, 2016YFC1303904
Kadoorie Charitable Foundation
Wellcome Trust	202922/Z/16/Z, 088158/Z/09/Z, 104085/Z/14/Z
Chinese Ministry of Science and Technology	2011BAI09B01
Breast Cancer Research Foundation

Keywords

Breast cancer
Dose–response meta-analysis
Prospective cohort study
Soy intake

ASJC Scopus subject areas

Epidemiology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Cite this

Wei, Y., Lv, J., Guo, Y., Bian, Z., Gao, M., Du, H., Yang, L., Chen, Y., Zhang, X., Wang, T., Chen, J., Chen, Z., Yu, C., Huo, D., Li, L., & China Kadoorie Biobank (CKB) collaborative group (2020). Soy intake and breast cancer risk: a prospective study of 300,000 Chinese women and a dose–response meta-analysis. European Journal of Epidemiology, 35(6), 567-578. https://doi.org/10.1007/s10654-019-00585-4

Wei, Y, Lv, J, Guo, Y, Bian, Z, Gao, M, Du, H, Yang, L, Chen, Y, Zhang, X, Wang, T, Chen, J, Chen, Z, Yu, C, Huo, D, Li, L & China Kadoorie Biobank (CKB) collaborative group 2020, 'Soy intake and breast cancer risk: a prospective study of 300,000 Chinese women and a dose–response meta-analysis', European Journal of Epidemiology, vol. 35, no. 6, pp. 567-578. https://doi.org/10.1007/s10654-019-00585-4

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abstract = "Epidemiological evidence on the association of soy intake with breast cancer risk is still inconsistent due to different soy intake levels across previous studies and small number of breast cancer cases. We aimed to investigate this issue by analyzing data from the China Kadoorie Biobank (CKB) study and conducting a dose–response meta-analysis to integrate existing evidence. The CKB study included over 300,000 women aged 30–79 from 10 regions across China enrolled between 2004 and 2008, and followed-up for breast cancer events until 31 December 2016. Information on soy intake was collected from baseline, two resurveys and twelve 24-h dietary recalls. We also searched for relevant prospective cohort studies to do a dose–response meta-analysis. The mean (SD) soy intake was 9.4 (5.4) mg/day soy isoflavones among CKB women. During 10 years of follow-up, 2289 women developed breast cancers. The multivariable-adjusted relative risk was 1.00 (95% confidence interval [CI] 0.81–1.22) for the fourth (19.1 mg/day) versus the first (4.5 mg/day) soy isoflavone intake quartile. Meta-analysis of prospective studies found that each 10 mg/day increment in soy isoflavone intake was associated with a 3% (95% CI 1–5%) reduced risk of breast cancer. The CKB study demonstrated that moderate soy intake was not associated with breast cancer risk among Chinese women. Higher amount of soy intake might provide reasonable benefits for the prevention of breast cancer.",

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Soy intake and breast cancer risk: a prospective study of 300,000 Chinese women and a dose–response meta-analysis

Abstract

Bibliographical note

Funder

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

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