Six year incidence and progression of diabetic retinopathy: results from the Mauritius diabetes complication study

Robyn J Tapp; Paul Z Zimmet; C Alex Harper; Daniel J McCarty; Pierrot Chitson; Andrew M Tonkin; Stefan Söderberg; Hugh R Taylor; K G M M Alberti; Jaakko Tuomilehto; Jonathan E Shaw

doi:10.1016/j.diabres.2006.02.009

Six year incidence and progression of diabetic retinopathy: results from the Mauritius diabetes complication study

Robyn J Tapp, Paul Z Zimmet, C Alex Harper, Daniel J McCarty, Pierrot Chitson, Andrew M Tonkin, Stefan Söderberg, Hugh R Taylor, K G M M Alberti, Jaakko Tuomilehto, Jonathan E Shaw

Research output: Contribution to journal › Article › peer-review

34 Citations (Scopus)

Abstract

AIMS: To determine the incidence, progression and risk factors for diabetic retinopathy in the multiethnic population of Mauritius.

METHOD: A longitudinal, population-based study was conducted in Mauritius, during 1987, 1992 and 1998. Participants identified through the study as having diabetes (both known and newly diagnosed, by self-report and oral glucose tolerance test) and one in four participants with impaired glucose tolerance (IGT) underwent complications screening in 1992 and 1998. Retinal photographs were taken using a TRC-50VT retinal camera in three fields of the right eye (centred on the optic disc; macula (temporal to the optic disc); and nasal to disc). Photographs were graded according to a simplified version of the Wisconsin grading system.

RESULTS: The 6-year incidence of diabetic retinopathy was 23.8% (sight-threatening in 0.4%). Among those with known diabetes mellitus (KDM) and free of retinopathy at baseline the incidence of non-proliferative diabetic retinopathy (NPDR) was 29.2% and proliferative diabetic retinopathy (PDR) was 1.0%. Among those with newly diagnosed diabetes mellitus (NDM) at baseline the incidence of NPDR was 19.1% (no incident cases of PDR were found). Independent risk factors for retinopathy using the baseline population characteristics were duration of diabetes and fasting plasma glucose.

CONCLUSIONS: This is one of the few recent population-based studies of diabetic retinopathy undertaken in a developing nation. The incidence of retinopathy in Mauritius was high among those with NDM at baseline, with one in five developing retinopathy over 6 years. These results support the concept that screening for diabetes is important.

Original language	English
Pages (from-to)	298-303
Number of pages	6
Journal	Diabetes Research and Clinical Practice
Volume	73
Issue number	3
Early online date	3 Apr 2006
DOIs	https://doi.org/10.1016/j.diabres.2006.02.009
Publication status	Published - Sept 2006
Externally published	Yes

Keywords

Adult
Blood Glucose/analysis
Blood Pressure/physiology
Diabetes Complications/blood
Diabetic Retinopathy/epidemiology
Disease Progression
Female
Humans
Incidence
Longitudinal Studies
Male
Mauritius/epidemiology
Middle Aged
Risk Factors

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.diabres.2006.02.009

Cite this

Tapp, R. J., Zimmet, P. Z., Harper, C. A., McCarty, D. J., Chitson, P., Tonkin, A. M., Söderberg, S., Taylor, H. R., Alberti, K. G. M. M., Tuomilehto, J., & Shaw, J. E. (2006). Six year incidence and progression of diabetic retinopathy: results from the Mauritius diabetes complication study. Diabetes Research and Clinical Practice, 73(3), 298-303. https://doi.org/10.1016/j.diabres.2006.02.009

Tapp, RJ, Zimmet, PZ, Harper, CA, McCarty, DJ, Chitson, P, Tonkin, AM, Söderberg, S, Taylor, HR, Alberti, KGMM, Tuomilehto, J & Shaw, JE 2006, 'Six year incidence and progression of diabetic retinopathy: results from the Mauritius diabetes complication study', Diabetes Research and Clinical Practice, vol. 73, no. 3, pp. 298-303. https://doi.org/10.1016/j.diabres.2006.02.009

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title = "Six year incidence and progression of diabetic retinopathy: results from the Mauritius diabetes complication study",

abstract = "AIMS: To determine the incidence, progression and risk factors for diabetic retinopathy in the multiethnic population of Mauritius.METHOD: A longitudinal, population-based study was conducted in Mauritius, during 1987, 1992 and 1998. Participants identified through the study as having diabetes (both known and newly diagnosed, by self-report and oral glucose tolerance test) and one in four participants with impaired glucose tolerance (IGT) underwent complications screening in 1992 and 1998. Retinal photographs were taken using a TRC-50VT retinal camera in three fields of the right eye (centred on the optic disc; macula (temporal to the optic disc); and nasal to disc). Photographs were graded according to a simplified version of the Wisconsin grading system.RESULTS: The 6-year incidence of diabetic retinopathy was 23.8% (sight-threatening in 0.4%). Among those with known diabetes mellitus (KDM) and free of retinopathy at baseline the incidence of non-proliferative diabetic retinopathy (NPDR) was 29.2% and proliferative diabetic retinopathy (PDR) was 1.0%. Among those with newly diagnosed diabetes mellitus (NDM) at baseline the incidence of NPDR was 19.1% (no incident cases of PDR were found). Independent risk factors for retinopathy using the baseline population characteristics were duration of diabetes and fasting plasma glucose.CONCLUSIONS: This is one of the few recent population-based studies of diabetic retinopathy undertaken in a developing nation. The incidence of retinopathy in Mauritius was high among those with NDM at baseline, with one in five developing retinopathy over 6 years. These results support the concept that screening for diabetes is important.",

keywords = "Adult, Blood Glucose/analysis, Blood Pressure/physiology, Diabetes Complications/blood, Diabetic Retinopathy/epidemiology, Disease Progression, Female, Humans, Incidence, Longitudinal Studies, Male, Mauritius/epidemiology, Middle Aged, Risk Factors",

author = "Tapp, {Robyn J} and Zimmet, {Paul Z} and Harper, {C Alex} and McCarty, {Daniel J} and Pierrot Chitson and Tonkin, {Andrew M} and Stefan S{\"o}derberg and Taylor, {Hugh R} and Alberti, {K G M M} and Jaakko Tuomilehto and Shaw, {Jonathan E}",

year = "2006",

month = sep,

doi = "10.1016/j.diabres.2006.02.009",

language = "English",

volume = "73",

pages = "298--303",

journal = "Diabetes Research and Clinical Practice",

issn = "0168-8227",

publisher = "Elsevier Ireland Ltd",

number = "3",

}

TY - JOUR

T1 - Six year incidence and progression of diabetic retinopathy

T2 - results from the Mauritius diabetes complication study

AU - Tapp, Robyn J

AU - Zimmet, Paul Z

AU - Harper, C Alex

AU - McCarty, Daniel J

AU - Chitson, Pierrot

AU - Tonkin, Andrew M

AU - Söderberg, Stefan

AU - Taylor, Hugh R

AU - Alberti, K G M M

AU - Tuomilehto, Jaakko

AU - Shaw, Jonathan E

PY - 2006/9

Y1 - 2006/9

N2 - AIMS: To determine the incidence, progression and risk factors for diabetic retinopathy in the multiethnic population of Mauritius.METHOD: A longitudinal, population-based study was conducted in Mauritius, during 1987, 1992 and 1998. Participants identified through the study as having diabetes (both known and newly diagnosed, by self-report and oral glucose tolerance test) and one in four participants with impaired glucose tolerance (IGT) underwent complications screening in 1992 and 1998. Retinal photographs were taken using a TRC-50VT retinal camera in three fields of the right eye (centred on the optic disc; macula (temporal to the optic disc); and nasal to disc). Photographs were graded according to a simplified version of the Wisconsin grading system.RESULTS: The 6-year incidence of diabetic retinopathy was 23.8% (sight-threatening in 0.4%). Among those with known diabetes mellitus (KDM) and free of retinopathy at baseline the incidence of non-proliferative diabetic retinopathy (NPDR) was 29.2% and proliferative diabetic retinopathy (PDR) was 1.0%. Among those with newly diagnosed diabetes mellitus (NDM) at baseline the incidence of NPDR was 19.1% (no incident cases of PDR were found). Independent risk factors for retinopathy using the baseline population characteristics were duration of diabetes and fasting plasma glucose.CONCLUSIONS: This is one of the few recent population-based studies of diabetic retinopathy undertaken in a developing nation. The incidence of retinopathy in Mauritius was high among those with NDM at baseline, with one in five developing retinopathy over 6 years. These results support the concept that screening for diabetes is important.

AB - AIMS: To determine the incidence, progression and risk factors for diabetic retinopathy in the multiethnic population of Mauritius.METHOD: A longitudinal, population-based study was conducted in Mauritius, during 1987, 1992 and 1998. Participants identified through the study as having diabetes (both known and newly diagnosed, by self-report and oral glucose tolerance test) and one in four participants with impaired glucose tolerance (IGT) underwent complications screening in 1992 and 1998. Retinal photographs were taken using a TRC-50VT retinal camera in three fields of the right eye (centred on the optic disc; macula (temporal to the optic disc); and nasal to disc). Photographs were graded according to a simplified version of the Wisconsin grading system.RESULTS: The 6-year incidence of diabetic retinopathy was 23.8% (sight-threatening in 0.4%). Among those with known diabetes mellitus (KDM) and free of retinopathy at baseline the incidence of non-proliferative diabetic retinopathy (NPDR) was 29.2% and proliferative diabetic retinopathy (PDR) was 1.0%. Among those with newly diagnosed diabetes mellitus (NDM) at baseline the incidence of NPDR was 19.1% (no incident cases of PDR were found). Independent risk factors for retinopathy using the baseline population characteristics were duration of diabetes and fasting plasma glucose.CONCLUSIONS: This is one of the few recent population-based studies of diabetic retinopathy undertaken in a developing nation. The incidence of retinopathy in Mauritius was high among those with NDM at baseline, with one in five developing retinopathy over 6 years. These results support the concept that screening for diabetes is important.

KW - Adult

KW - Blood Glucose/analysis

KW - Blood Pressure/physiology

KW - Diabetes Complications/blood

KW - Diabetic Retinopathy/epidemiology

KW - Disease Progression

KW - Female

KW - Humans

KW - Incidence

KW - Longitudinal Studies

KW - Male

KW - Mauritius/epidemiology

KW - Middle Aged

KW - Risk Factors

U2 - 10.1016/j.diabres.2006.02.009

DO - 10.1016/j.diabres.2006.02.009

M3 - Article

C2 - 16584802

SN - 0168-8227

VL - 73

SP - 298

EP - 303

JO - Diabetes Research and Clinical Practice

JF - Diabetes Research and Clinical Practice

IS - 3

ER -

Six year incidence and progression of diabetic retinopathy: results from the Mauritius diabetes complication study

Abstract

Keywords

UN SDGs

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