It is known that peptides derived from intracellular loop 3 of G-protein-coupled receptors are able to activate G-proteins [l], and these studies have shed some light on the mechanism of activation.
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Gouldson, P. R., & Reynolds, C. A. (1997). Simulations on dimeric peptides: Evidence for domain swapping in G-protein-coupled receptors? Biochemical Society Transactions, 25(3), 1066-1071. https://doi.org/10.1042/bst0251066