Simulation study of electrotonic coupling between human atrial myocytes and mechanosensitive fibroblasts

Honglian Su, Heqing Zhan, Yinglan Gong, Dingchang Zheng, Ling Xia

Research output: Contribution to journalConference article

Abstract

This study aimed to investigate the effect on adjacent myocyte of fibroblasts (Fbs) with the incorporation of mechano-gated currents induced by mechanical compression (Ici) of cardiac Fbs. The human atrial myocyte (hAM) was modeled by the Courtemanche-Ramirez-Nattel model. With two different experimentally observed Fbs compression (2μm and 3μm), Ici was numerically simulated as Icil and Icih. They were then incorporated into two types of electro physiological models of human atrial Fbs: passive and active models, respectively. In both passive and active models, lei depolarized the membrane potential of cardiac Fbs. When coupled with passive Fbs, the action potential of myocyte duration at 90% (APD90) was increased in comparison with uncoupled hAM With the incorporation of Ici into passive Fbs, APD90 of myocyte was further increased. When coupled with active Fbs, similar increases were obtained with the incorporation of both Ici Furthermore, the resting potential and the maximum value of the action potential of hAM were also increased for both models and with both Ici. The preliminary simulation study confirmed that mechanosentitive currents in fibroblasts play an important role in mechano-electrical coupling.

Original languageEnglish
Article number7043152
Pages (from-to)753-756
Number of pages4
JournalComputing in Cardiology
Volume41
Publication statusPublished - 19 Feb 2015
Externally publishedYes
Event41st Computing in Cardiology Conference, CinC 2014 - Cambridge, United States
Duration: 7 Sep 201410 Sep 2014

ASJC Scopus subject areas

  • Computer Science(all)
  • Cardiology and Cardiovascular Medicine

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