Abstract
The use of cholera vaccines has been increasingly recognized as an effective control measure in cholera endemic countries. However, guidelines for using vaccination during cholera outbreaks are still to be established, and it remains an open question as to how and when the vaccines should be deployed to best control ongoing cholera outbreaks. Here we formulate a new optimal control model to assess the value of cholera vaccines in epidemic settings and cost-effective optimal times to deploy a vaccine. Our results suggest that as long as the vaccine prices are sufficiently low, vaccination should always start from or immediately after the onset of a cholera outbreak.
| Original language | English |
|---|---|
| Article number | 1450014 |
| Journal | International Journal of Biomathematics |
| Volume | 7 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 21 Feb 2014 |
| Externally published | Yes |
Funding
J. Wang acknowledges partial support from the National Science Foundation under Grant Nos. 0813691 and 1216936. Z. Mukandavire was supported by the UF Science for Life Program, an interdisciplinary program with support from the Howard Hughes Medical Institute. The authors would like to thank the anonymous referees for helpful comments.
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Cholera epidemics
- optimal control
- vaccination
ASJC Scopus subject areas
- Modelling and Simulation
- Applied Mathematics
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