Simulating optimal vaccination times during cholera outbreaks

Chairat Modnak, Jin Wang, Zindoga Mukandavire

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


The use of cholera vaccines has been increasingly recognized as an effective control measure in cholera endemic countries. However, guidelines for using vaccination during cholera outbreaks are still to be established, and it remains an open question as to how and when the vaccines should be deployed to best control ongoing cholera outbreaks. Here we formulate a new optimal control model to assess the value of cholera vaccines in epidemic settings and cost-effective optimal times to deploy a vaccine. Our results suggest that as long as the vaccine prices are sufficiently low, vaccination should always start from or immediately after the onset of a cholera outbreak.

Original languageEnglish
Article number1450014
JournalInternational Journal of Biomathematics
Issue number2
Publication statusPublished - 21 Feb 2014
Externally publishedYes


  • Cholera epidemics
  • optimal control
  • vaccination

ASJC Scopus subject areas

  • Modelling and Simulation
  • Applied Mathematics


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