Sheath-less high throughput inertial separation of small microparticles in spiral microchannels with trapezoidal cross-section

Ala'aldeen Al-Halhouli, Ahmed Albagdady, Andreas Dietzel

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)
11 Downloads (Pure)

Abstract

Various mechanisms of different designs have emerged for the purpose of microparticle separation and cell sorting. The main goals behind such designs are to create high throughput and high purity sample isolation. In this study, high efficiency, high throughput and precise separation of microparticles under inertial lift and drag forces induced by trapezoidal curvilinear channels are reported. This work is the first to focus and recover 2 from 5 μm and 2 from 10 μm particles in spiral channels in a sheath-less flow device, which reduces the overall complexity of the system and allows for higher throughput. The new microfluidic chip design is fabricated in glass using femtosecond laser ablation. In addition, mathematical force calculations were conducted during the design phase of the microfluidic channels and compared with experiments. The results show a close prediction of the equilibrium position of the tested microparticles.

Original languageEnglish
Pages (from-to)41970-41976
Number of pages7
JournalRSC Advances
Volume9
Issue number71
DOIs
Publication statusPublished - 18 Dec 2019
Externally publishedYes

Bibliographical note

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Funder

This research is funded by the German Academic Exchange Services (DAAD) under the project entitled “Inertial focusing for continuous nanoparticles separation in femtosecond laser 3D micromachined curved channels”.

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